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Research ArticleMethods/New Tools, Novel Tools and Methods

Spontaneous Functional Recovery after Focal Damage in Neuronal Cultures

Sara Teller, Estefanía Estévez-Priego, Clara Granell, Daniel Tornero, Jordi Andilla, Omar E. Olarte, Pablo Loza-Alvarez, Alex Arenas and Jordi Soriano
eNeuro 9 December 2019, 7 (1) ENEURO.0254-19.2019; https://doi.org/10.1523/ENEURO.0254-19.2019
Sara Teller
1Departament de Física de la Matèria Condensada, Universitat de Barcelona, Barcelona 08028, Spain
2Universitat de Barcelona Institute of Complex Systems (UBICS), Barcelona 08028, Spain
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Estefanía Estévez-Priego
1Departament de Física de la Matèria Condensada, Universitat de Barcelona, Barcelona 08028, Spain
2Universitat de Barcelona Institute of Complex Systems (UBICS), Barcelona 08028, Spain
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Clara Granell
2Universitat de Barcelona Institute of Complex Systems (UBICS), Barcelona 08028, Spain
3GOTHAM Lab–Institute for Biocomputation and Physics of Complex Systems (BIFI), University of Zaragoza, Zaragoza 50018, Spain
4Department of Condensed Matter Physics, University of Zaragoza, Zaragoza 50009, Spain
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Daniel Tornero
1Departament de Física de la Matèria Condensada, Universitat de Barcelona, Barcelona 08028, Spain
5Departament de Biomedicina, Facultat de Medicina, Institut de Neurociències, Universitat de Barcelona, Barcelona 08036, Spain
6Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)
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  • ORCID record for Daniel Tornero
Jordi Andilla
7ICFO–Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, Castelldefels 08860, Spain
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Omar E. Olarte
7ICFO–Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, Castelldefels 08860, Spain
8Universidad ECCI, Bogotá 111311, Colombia
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Pablo Loza-Alvarez
7ICFO–Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, Castelldefels 08860, Spain
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Alex Arenas
9Departament d’Enginyeria Informàtica i Matemàtiques, Universitat Rovira i Virgili, Tarragona 43007, Spain
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Jordi Soriano
1Departament de Física de la Matèria Condensada, Universitat de Barcelona, Barcelona 08028, Spain
2Universitat de Barcelona Institute of Complex Systems (UBICS), Barcelona 08028, Spain
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0254-19.2019
PubMed 
31818830
Published By 
Society for Neuroscience
History 
  • Received June 27, 2019
  • Revision received November 18, 2019
  • Accepted November 29, 2019
  • Published online December 9, 2019.
Copyright & Usage 
Copyright © 2020 Teller et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Sara Teller1,2,
  2. Estefanía Estévez-Priego1,2,
  3. Clara Granell2,3,4,
  4. Daniel Tornero1,5,6,
  5. Jordi Andilla7,
  6. Omar E. Olarte7,8,
  7. Pablo Loza-Alvarez7,
  8. Alex Arenas9 and
  9. Jordi Soriano1,2
  1. 1Departament de Física de la Matèria Condensada, Universitat de Barcelona, Barcelona 08028, Spain
  2. 2Universitat de Barcelona Institute of Complex Systems (UBICS), Barcelona 08028, Spain
  3. 3GOTHAM Lab–Institute for Biocomputation and Physics of Complex Systems (BIFI), University of Zaragoza, Zaragoza 50018, Spain
  4. 4Department of Condensed Matter Physics, University of Zaragoza, Zaragoza 50009, Spain
  5. 5Departament de Biomedicina, Facultat de Medicina, Institut de Neurociències, Universitat de Barcelona, Barcelona 08036, Spain
  6. 6Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)
  7. 7ICFO–Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, Castelldefels 08860, Spain
  8. 8Universidad ECCI, Bogotá 111311, Colombia
  9. 9Departament d’Enginyeria Informàtica i Matemàtiques, Universitat Rovira i Virgili, Tarragona 43007, Spain
  1. Correspondence should be addressed to Jordi Soriano at jordi.soriano{at}ub.edu.
View Full Text

Author contributions

  1. Author contributions: S.T., J.A., P.L.-A., and J.S. designed research; S.T., J.A., and O.E.O. performed research; S.T., E.E.-P., C.G., D.T., and A.A. contributed unpublished reagents/analytic tools; S.T., E.E.-P., D.T., and J.S. analyzed data; S.T. and J.S. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This research is part of MESO-BRAIN. The MESO-BRAIN Project has received funding from the European Union’s Horizon 2020 Research and Innovation Programme Grant 713140 (to S.T., E.E.-P., J.A., O.E.O., P.L.-A., J.S.). J.S. and S.T. were supported by the Spanish Ministerio de Economia y Competitividad Projects FIS2013-41144-P, FIS2016-78507-C2-2-P, and FIS2017-90782-REDT (IBERSINC) and by the Generalitat de Catalunya Grant 2017-SGR-1061. C.G. was supported by Juan de la Cierva-Formación (Ministerio de Ciencia, Innovación y Universidades) and by the James S. McDonnell Foundation Postdoctoral Fellowship Grant 220020457. A.A. was supported by the Generalitat de Catalunya Project 2017-SGR-896, Spanish MINECO Projects FIS2015-71582-C2-1 and FIS2017-90782-REDT, ICREA Academia, and the James S. McDonnell Foundation Grant 220020325. J.A., O.E.O., and P.L.-A. were supported by the Spanish Ministerio de Economia y Competitividad (AEI/FEDER) Project FIS2016-80455-R, the “Severo Ochoa” Programme for Centers of Excellence in R&D (SEV-2015-0522), Fundació Privada Cellex, Fundación Mig-Puig, Generalitat de Catalunya through the CERCA program, and Laserlab-Europe (EU-H2020 654148).

Funding

  • EC | Horizon 2020 (EU Framework Programme for Research and Innovation)

    713140; Laserlab Europe 654148
  • Ministerio de Econom ía y Competitividad

    FIS2013-41144-P; FIS2016-78507-C2-2-P; FIS2017-90782-REDT; FIS2015-71582-C2-1; FIS2017-90782-REDT; FIS2016-80455-R
  • Generalitat de Catalunya (Government of Catalonia)

    2017-SGR-1061; 2017-SGR-896; CERCA Programme
  • Institució Catalana de Recerca i Estudis Avançats (ICREA)

  • James S. McDonnell Foundation (JSMF)

    220020325
  • Severo Ochoa Programme

    SEV-2015-0522
  • Fundación Cellex (Cellex Foundation)

  • Fundación Mig-puig

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  • previous version (December 09, 2019).

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Mar 20202515147
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Jun 20201121217
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Apr 202179114
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Apr 202261029
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Jan 2025610022
Feb 202548616
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Total 20253335974
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Spontaneous Functional Recovery after Focal Damage in Neuronal Cultures
Sara Teller, Estefanía Estévez-Priego, Clara Granell, Daniel Tornero, Jordi Andilla, Omar E. Olarte, Pablo Loza-Alvarez, Alex Arenas, Jordi Soriano
eNeuro 9 December 2019, 7 (1) ENEURO.0254-19.2019; DOI: 10.1523/ENEURO.0254-19.2019

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Spontaneous Functional Recovery after Focal Damage in Neuronal Cultures
Sara Teller, Estefanía Estévez-Priego, Clara Granell, Daniel Tornero, Jordi Andilla, Omar E. Olarte, Pablo Loza-Alvarez, Alex Arenas, Jordi Soriano
eNeuro 9 December 2019, 7 (1) ENEURO.0254-19.2019; DOI: 10.1523/ENEURO.0254-19.2019
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Keywords

  • calcium imaging
  • focal damage
  • functional recovery
  • laser microsurgery
  • network neuroscience
  • neuronal cultures

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