Skip to main content

Umbrella menu

  • SfN.org
  • eNeuro
  • The Journal of Neuroscience
  • Neuronline
  • BrainFacts.org

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Latest Articles
    • Issue Archive
    • Editorials
    • Research Highlights
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • EDITORIAL BOARD
  • BLOG
  • ABOUT
    • Overview
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
  • SfN.org
  • eNeuro
  • The Journal of Neuroscience
  • Neuronline
  • BrainFacts.org

User menu

  • My alerts

Search

  • Advanced search
eNeuro
  • My alerts

eNeuro

Advanced Search

Submit a Manuscript
  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Latest Articles
    • Issue Archive
    • Editorials
    • Research Highlights
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • EDITORIAL BOARD
  • BLOG
  • ABOUT
    • Overview
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
PreviousNext
Research ArticleNew Research, Sensory and Motor Systems

Odor-Induced Multi-Level Inhibitory Maps in Drosophila

Veit Grabe, Marco Schubert, Martin Strube-Bloss, Anja Reinert, Silke Trautheim, Sofia Lavista-Llanos, André Fiala, Bill S. Hansson and Silke Sachse
eNeuro 30 December 2019, 7 (1) ENEURO.0213-19.2019; DOI: https://doi.org/10.1523/ENEURO.0213-19.2019
Veit Grabe
1Department of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Jena 07745, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Veit Grabe
Marco Schubert
1Department of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Jena 07745, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Marco Schubert
Martin Strube-Bloss
1Department of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Jena 07745, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Martin Strube-Bloss
Anja Reinert
1Department of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Jena 07745, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Silke Trautheim
1Department of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Jena 07745, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sofia Lavista-Llanos
1Department of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Jena 07745, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
André Fiala
2Department of Molecular Neurobiology of Behavior, Johann-Friedrich-Blumenbach-Institute for Zoology and Anthropology, University of Göttingen, Göttingen 37077, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Bill S. Hansson
1Department of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Jena 07745, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Bill S. Hansson
Silke Sachse
1Department of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Jena 07745, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Silke Sachse
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

Optical imaging of intracellular Ca2+ influx as a correlate of neuronal excitation represents a standard technique for visualizing spatiotemporal activity of neuronal networks. However, the information-processing properties of single neurons and neuronal circuits likewise involve inhibition of neuronal membrane potential. Here, we report spatially resolved optical imaging of odor-evoked inhibitory patterns in the olfactory circuitry of Drosophila using a genetically encoded fluorescent Cl- sensor. In combination with the excitatory component reflected by intracellular Ca2+ dynamics, we present a comprehensive functional map of both odor-evoked neuronal activation and inhibition at different levels of olfactory processing. We demonstrate that odor-evoked inhibition carried by Cl- influx is present both in sensory neurons and second-order projection neurons (PNs), and is characterized by stereotypic, odor-specific patterns. Cl--mediated inhibition features distinct dynamics in different neuronal populations. Our data support a dual role of inhibitory neurons in the olfactory system: global gain control across the neuronal circuitry and glomerulus-specific inhibition to enhance neuronal information processing.

  • antennal lobe
  • chloride imaging
  • Drosophila
  • inhibition
  • olfactory coding
  • sensory processing

Footnotes

  • The authors declare no competing financial interests.

  • This work was supported by a Federal Ministry of Education and Research (BMBF) grant (S.S., V.G., M.S.-B., A.R. and S.T.), by the Max Planck Society, and by German Research Foundation Grants SPP1392 FI-3-1 and SA 909/3-1, 3-2 (A.F. and S.S.).

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

View Full Text
Back to top

In this issue

eneuro: 7 (1)
eNeuro
Vol. 7, Issue 1
January/February 2020
  • Table of Contents
  • Index by author
Email

Thank you for sharing this eNeuro article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Odor-Induced Multi-Level Inhibitory Maps in Drosophila
(Your Name) has forwarded a page to you from eNeuro
(Your Name) thought you would be interested in this article in eNeuro.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Citation Tools
Odor-Induced Multi-Level Inhibitory Maps in Drosophila
Veit Grabe, Marco Schubert, Martin Strube-Bloss, Anja Reinert, Silke Trautheim, Sofia Lavista-Llanos, André Fiala, Bill S. Hansson, Silke Sachse
eNeuro 30 December 2019, 7 (1) ENEURO.0213-19.2019; DOI: 10.1523/ENEURO.0213-19.2019

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Share
Odor-Induced Multi-Level Inhibitory Maps in Drosophila
Veit Grabe, Marco Schubert, Martin Strube-Bloss, Anja Reinert, Silke Trautheim, Sofia Lavista-Llanos, André Fiala, Bill S. Hansson, Silke Sachse
eNeuro 30 December 2019, 7 (1) ENEURO.0213-19.2019; DOI: 10.1523/ENEURO.0213-19.2019
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Significance Statement
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Acknowledgments
    • Footnotes
    • References
    • Synthesis
    • Author Response
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • antennal lobe
  • chloride imaging
  • Drosophila
  • inhibition
  • olfactory coding
  • sensory processing

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

New Research

  • Food-seeking behavior is mediated by Fos-expressing neuronal ensembles formed at first learning in rats
  • Deficiency of microglial autophagy increases the density of oligodendrocytes and susceptibility to severe forms of seizures
  • Arginine Vasopressin-Containing Neurons of the Suprachiasmatic Nucleus Project to CSF
Show more New Research

Sensory and Motor Systems

  • Arginine Vasopressin-Containing Neurons of the Suprachiasmatic Nucleus Project to CSF
  • An Atoh1 CRE knock-in mouse labels motor neurons involved in fine motor control
  • Neural correlates of vocal auditory feedback processing: Unique insights from electrocorticography recordings in a human cochlear implant user
Show more Sensory and Motor Systems

Subjects

  • Sensory and Motor Systems
  • Home
  • Alerts
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Latest Articles
  • Issue Archive
  • Blog
  • Browse by Topic

Information

  • For Authors
  • For the Media

About

  • About the Journal
  • Editorial Board
  • Privacy Policy
  • Contact
  • Feedback
(eNeuro logo)
(SfN logo)

Copyright © 2021 by the Society for Neuroscience.
eNeuro eISSN: 2373-2822

The ideas and opinions expressed in eNeuro do not necessarily reflect those of SfN or the eNeuro Editorial Board. Publication of an advertisement or other product mention in eNeuro should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in eNeuro.