LRIT3 is Required for Nyctalopin Expression and Normal ON and OFF Pathway Signaling in the Retina

Nazarul Hasan; Gobinda Pangeni; Thomas A. Ray; Kathryn M. Fransen; Jennifer Noel; Bart G. Borghuis; Maureen A. McCall; Ronald G. Gregg

doi:10.1523/ENEURO.0002-20.2020

Article Information

DOI

https://doi.org/10.1523/ENEURO.0002-20.2020

PubMed

31959619

Published By

Society for Neuroscience

History

Received December 30, 2019
Accepted January 5, 2020
Published online January 20, 2020.

Copyright © 2020 Hasan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

Nazarul Hasan¹,
Gobinda Pangeni²,
Thomas A. Ray¹,
Kathryn M. Fransen²,
Jennifer Noel²,³,
Bart G. Borghuis³,
Maureen A. McCall²,³ and
Ronald G. Gregg¹,²

¹Department of Biochemistry and Molecular Genetics, University of Louisville, Louisville, KY 40292
²Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY 40292
³Department of Anatomical Sciences and Neurobiology, University of Louisville, Louisville, KY 40292

Correspondence should be addressed to Ronald G. Gregg at ron.gregg{at}louisville.edu.

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Author contributions

Author contributions: N.H., B.G.B., M.A.M., and R.G.G. designed research; N.H., G.P., T.A.R., K.M.F., J.N., and B.G.B. performed research; N.H., G.P., J.N., B.G.B., M.A.M., and R.G.G. analyzed data; B.G.B., M.A.M., and R.G.G. wrote the paper.

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Disclosures

M.A.M. is Kentucky Lions Eye Research Endowed Chair and R.G.G. Preston Joyes Pope Endowed Chair. All other authors declare no competing financial interests.
This work was supported by National Institutes of Health Grants R01 EY12354 (to R.G.G., M.A.M., N.H.), R01 EY014701 and EY028719 (to M.A.M.), and R01 EY028188 (to B.G.B.) and by an unrestricted grant from Research to Prevent Blindness to the Department of Ophthalmology and Visual Science, University of Louisville, Kentucky.