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Research ArticleNew Research, Development

Environmental Enrichment Partially Repairs Subcortical Mapping Errors in Ten-m3 Knock-Out Mice during an Early Critical Period

Peta Eggins, James Blok, Justin Petersen, Larissa Savvas, Lara Rogerson-Wood, Hannan Mansuri, Atomu Sawatari and Catherine A. Leamey
eNeuro 25 November 2019, 6 (6) ENEURO.0478-18.2019; DOI: https://doi.org/10.1523/ENEURO.0478-18.2019
Peta Eggins
Discipline of Physiology, School of Medical Sciences and Bosch Institute, Faculty of Medicine and Health, University of Sydney, New South Wales 2006, Australia
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James Blok
Discipline of Physiology, School of Medical Sciences and Bosch Institute, Faculty of Medicine and Health, University of Sydney, New South Wales 2006, Australia
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Justin Petersen
Discipline of Physiology, School of Medical Sciences and Bosch Institute, Faculty of Medicine and Health, University of Sydney, New South Wales 2006, Australia
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Larissa Savvas
Discipline of Physiology, School of Medical Sciences and Bosch Institute, Faculty of Medicine and Health, University of Sydney, New South Wales 2006, Australia
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Lara Rogerson-Wood
Discipline of Physiology, School of Medical Sciences and Bosch Institute, Faculty of Medicine and Health, University of Sydney, New South Wales 2006, Australia
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Hannan Mansuri
Discipline of Physiology, School of Medical Sciences and Bosch Institute, Faculty of Medicine and Health, University of Sydney, New South Wales 2006, Australia
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Atomu Sawatari
Discipline of Physiology, School of Medical Sciences and Bosch Institute, Faculty of Medicine and Health, University of Sydney, New South Wales 2006, Australia
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Catherine A. Leamey
Discipline of Physiology, School of Medical Sciences and Bosch Institute, Faculty of Medicine and Health, University of Sydney, New South Wales 2006, Australia
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Abstract

Environmental enrichment (EE) has been shown to improve neural function via the regulation of cortical plasticity. Its capacity to induce functional and/or anatomical repair of miswired circuits is unknown. Ten-m3 knock-out (KO) mice exhibit a highly stereotyped and profound miswiring of ipsilateral retinogeniculate axons and associated deficits in binocularly-mediated visual behavior. We determined whether, and when, EE can drive the repair of subcortical wiring deficits by analyzing Ten-m3 KO and wild-type (WT) mice that were enriched for six weeks from adulthood, weaning or birth in comparison to standard-housed (SE) controls. Six weeks of EE initiated from birth, but not later, induced a significant reduction in the area occupied by ipsilateral retinogeniculate terminals in KOs. No EE-induced correction of mistargeted axons was observed at postnatal day (P)7, indicating that this intervention impacts pruning rather than initial targeting of axons. This reduction was most prominent in the ventrolateral region of the dorsal lateral geniculate nucleus (dLGN), suggesting a preferential pruning of the most profoundly mistargeted axons. EE can thus partially repair a specific, subcortical axonal wiring deficit, but only during an early, developmentally-restricted time window.

  • axon guidance
  • binocular
  • dLGN
  • ipsilateral
  • plasticity
  • teneurin/Ten-m/Odz

Footnotes

  • The authors declare no competing financial interests.

  • Support in of the early stages of this work was provided by the National Health and Medical Research Council Project Grant 632685 (to C.A.L.).

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Environmental Enrichment Partially Repairs Subcortical Mapping Errors in Ten-m3 Knock-Out Mice during an Early Critical Period
Peta Eggins, James Blok, Justin Petersen, Larissa Savvas, Lara Rogerson-Wood, Hannan Mansuri, Atomu Sawatari, Catherine A. Leamey
eNeuro 25 November 2019, 6 (6) ENEURO.0478-18.2019; DOI: 10.1523/ENEURO.0478-18.2019

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Environmental Enrichment Partially Repairs Subcortical Mapping Errors in Ten-m3 Knock-Out Mice during an Early Critical Period
Peta Eggins, James Blok, Justin Petersen, Larissa Savvas, Lara Rogerson-Wood, Hannan Mansuri, Atomu Sawatari, Catherine A. Leamey
eNeuro 25 November 2019, 6 (6) ENEURO.0478-18.2019; DOI: 10.1523/ENEURO.0478-18.2019
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Keywords

  • axon guidance
  • binocular
  • dLGN
  • ipsilateral
  • plasticity
  • teneurin/Ten-m/Odz

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