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Research ArticleFeature: Research Highlights, Disorders of the Nervous System

Does Prenatal Exposure to Maternal Inflammation Causes Sex Differences in Schizophrenia-Related Behavioral Outcomes in Adult Rats?

Rosalind S.E. Carney [DPhil]
eNeuro 12 November 2019, 6 (6) ENEURO.0393-19.2019; https://doi.org/10.1523/ENEURO.0393-19.2019
Rosalind S.E. Carney
DPhil
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    Figure 1.

    Flowchart depicting the order of the battery of behavioral tests (Adapted from Figure 1 in Lins et al., 2019.).

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    Figure 2.

    Experimental setup and results of cross-modal recognition task. A, The Y maze assembled for the cross-modal phase, which has a tactile sample phase and visual test phase. B, Adult offspring prenatally exposed to polyI:C or saline failed to display cross-modal recognition memory as novel object exploration was equal to chance. Schematic has been published previously (Lins et al., 2018; Paylor et al., 2016) (Adapted from Figure 4 in Lins et al., 2019.).

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    Figure 3.

    Experimental setup and results of the oddity discrimination task. A, Schematic of the white square arena used to conduct the oddity discrimination task showing the arrangement of three identical objects and one different, or odd, object. The schematic has been published previously (Lins et al., 2018). B, Bar graph displaying the percentage of total object exploration spent examining the odd object. Prenatally polyI:C-exposed adult offspring displayed significantly less oddity preference than offspring exposed to saline prenatally (*p < 0.05). (Figure 5 from Lins et al., 2019.).

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eneuro: 6 (6)
eNeuro
Vol. 6, Issue 6
November/December 2019
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Does Prenatal Exposure to Maternal Inflammation Causes Sex Differences in Schizophrenia-Related Behavioral Outcomes in Adult Rats?
Rosalind S.E. Carney [DPhil]
eNeuro 12 November 2019, 6 (6) ENEURO.0393-19.2019; DOI: 10.1523/ENEURO.0393-19.2019

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Does Prenatal Exposure to Maternal Inflammation Causes Sex Differences in Schizophrenia-Related Behavioral Outcomes in Adult Rats?
Rosalind S.E. Carney [DPhil]
eNeuro 12 November 2019, 6 (6) ENEURO.0393-19.2019; DOI: 10.1523/ENEURO.0393-19.2019
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