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Research ArticleNew Research, Integrative Systems

Charge-Balanced Electrical Stimulation Can Modulate Neural Precursor Cell Migration in the Presence of Endogenous Electric Fields in Mouse Brains

Stephanie N. Iwasa, Abdolazim Rashidi, Elana Sefton, Nancy X. Liu, Milos R. Popovic and Cindi M. Morshead
eNeuro 26 November 2019, 6 (6) ENEURO.0382-19.2019; https://doi.org/10.1523/ENEURO.0382-19.2019
Stephanie N. Iwasa
1Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada
2KITE, Toronto Rehabilitation Institute, University Health Network, Toronto, Ontario M5G 2A2, Canada
5CRANIA, University Health Network & University of Toronto, Toronto, Ontario M5G 2A2, Canada
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Abdolazim Rashidi
2KITE, Toronto Rehabilitation Institute, University Health Network, Toronto, Ontario M5G 2A2, Canada
5CRANIA, University Health Network & University of Toronto, Toronto, Ontario M5G 2A2, Canada
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Elana Sefton
1Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada
2KITE, Toronto Rehabilitation Institute, University Health Network, Toronto, Ontario M5G 2A2, Canada
5CRANIA, University Health Network & University of Toronto, Toronto, Ontario M5G 2A2, Canada
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Nancy X. Liu
3Department of Surgery, University of Toronto, Toronto, Ontario M5T 1P5, Canada
4Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada
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Milos R. Popovic
1Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada
2KITE, Toronto Rehabilitation Institute, University Health Network, Toronto, Ontario M5G 2A2, Canada
5CRANIA, University Health Network & University of Toronto, Toronto, Ontario M5G 2A2, Canada
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Cindi M. Morshead
1Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada
2KITE, Toronto Rehabilitation Institute, University Health Network, Toronto, Ontario M5G 2A2, Canada
3Department of Surgery, University of Toronto, Toronto, Ontario M5T 1P5, Canada
4Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada
5CRANIA, University Health Network & University of Toronto, Toronto, Ontario M5G 2A2, Canada
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0382-19.2019
PubMed 
31772032
Published By 
Society for Neuroscience
History 
  • Received September 23, 2019
  • Revision received November 5, 2019
  • Accepted November 8, 2019
  • Published online November 26, 2019.
Copyright & Usage 
Copyright © 2019 Iwasa et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Stephanie N. Iwasa1,2,5,
  2. Abdolazim Rashidi2,5,
  3. Elana Sefton1,2,5,
  4. Nancy X. Liu3,4,
  5. Milos R. Popovic1,2,5 and
  6. Cindi M. Morshead1,2,3,4,5
  1. 1Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada
  2. 2KITE, Toronto Rehabilitation Institute, University Health Network, Toronto, Ontario M5G 2A2, Canada
  3. 3Department of Surgery, University of Toronto, Toronto, Ontario M5T 1P5, Canada
  4. 4Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada
  5. 5CRANIA, University Health Network & University of Toronto, Toronto, Ontario M5G 2A2, Canada
  1. Correspondence should be addressed to Cindi M. Morshead at cindi.morshead{at}utoronto.ca.
View Full Text

Author contributions

  1. Author contributions: S.N.I., M.R.P., and C.M.M. designed research; S.N.I. and E.S. performed research; S.N.I., N.X.L., and C.M.M. analyzed data; S.N.I. and C.M.M. wrote the paper; A.R. contributed unpublished reagents/analytic tools.

Disclosures

  • C.M.M. and M.R.P. hold a patent in biphasic electrical stimulation. All other authors declare no competing financial interests.

  • This work was supported by the Connaught Innovation Fund (C.M.M.) and the Ontario Institute of Regenerative Medicine (C.M.M., M.R.P.). S.N.I. was the recipient of the Barbara and Frank Milligan Award (University of Toronto), Health Commercialization Award (University of Toronto), and the Wildcat Graduate Scholarship (University of Toronto).

Funding

  • Connaught Innovation Fund

  • Ontario Institute for Regenerative Medicine (OIRM)

  • Barbara and Frank Milligan Award

  • Health Commercialization Awaard

  • Wildcat Graduate Scholarship

Other Version

  • You are viewing the most recent version of this article.
  • previous version (November 26, 2019).

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Nov 201993039
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Total 20202081420342
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Jan 20261110625
Feb 20261116418
Mar 20261313148
Apr 2026105828
Total 202645459119
Total108154851730
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Charge-Balanced Electrical Stimulation Can Modulate Neural Precursor Cell Migration in the Presence of Endogenous Electric Fields in Mouse Brains
Stephanie N. Iwasa, Abdolazim Rashidi, Elana Sefton, Nancy X. Liu, Milos R. Popovic, Cindi M. Morshead
eNeuro 26 November 2019, 6 (6) ENEURO.0382-19.2019; DOI: 10.1523/ENEURO.0382-19.2019

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Charge-Balanced Electrical Stimulation Can Modulate Neural Precursor Cell Migration in the Presence of Endogenous Electric Fields in Mouse Brains
Stephanie N. Iwasa, Abdolazim Rashidi, Elana Sefton, Nancy X. Liu, Milos R. Popovic, Cindi M. Morshead
eNeuro 26 November 2019, 6 (6) ENEURO.0382-19.2019; DOI: 10.1523/ENEURO.0382-19.2019
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Keywords

  • cell migration
  • corpus callosum
  • electric fields
  • electrical stimulation
  • neural stem cells

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