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Research ArticleMethods/New Tools, Novel Tools and Methods

Chemogenetic Activation of Excitatory Neurons Alters Hippocampal Neurotransmission in a Dose-Dependent Manner

Sthitapranjya Pati, Sonali S. Salvi, Mamata Kallianpur, Bhupesh Vaidya, Antara Banerjee, Sudipta Maiti, James P. Clement and Vidita A. Vaidya
eNeuro 23 October 2019, 6 (6) ENEURO.0124-19.2019; https://doi.org/10.1523/ENEURO.0124-19.2019
Sthitapranjya Pati
1Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India
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Sonali S. Salvi
1Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India
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Mamata Kallianpur
2Department of Chemical Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India
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Bhupesh Vaidya
3Neuroscience Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560064, India
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  • ORCID record for Bhupesh Vaidya
Antara Banerjee
1Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India
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Sudipta Maiti
2Department of Chemical Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India
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James P. Clement
3Neuroscience Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560064, India
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Vidita A. Vaidya
1Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0124-19.2019
PubMed 
31645362
Published By 
Society for Neuroscience
History 
  • Received April 1, 2019
  • Revision received September 26, 2019
  • Accepted September 30, 2019
  • Published online October 23, 2019.
Copyright & Usage 
Copyright © 2019 Pati et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Sthitapranjya Pati1,
  2. Sonali S. Salvi1,
  3. Mamata Kallianpur2,
  4. Bhupesh Vaidya3,
  5. Antara Banerjee1,
  6. Sudipta Maiti2,
  7. James P. Clement3,* and
  8. Vidita A. Vaidya1,*
  1. 1Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India
  2. 2Department of Chemical Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India
  3. 3Neuroscience Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560064, India
  1. Correspondence should be addressed to James P. Clement at clement{at}jncasr.ac.in or Vidita A. Vaidya at vvaidya{at}tifr.res.in.
View Full Text

Author contributions

  1. Author contributions: S.P., J.P.C., and V.A.V. designed research; S.P., S.S.S., M.K., B.V., and A.B. performed research; S.P., S.S.S., and B.V. analyzed data; S.P. and V.A.V. wrote the paper; S.M. contributed unpublished reagents/analytic tools.

  2. ↵* J.P.C. and V.A.V. contributed equally to this work.

View Abstract

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by a Tata Institute of Fundamental Research intramural grant (V.A.V.), a Jawaharlal Nehru Centre for Advanced Scientific Research intramural grant (J.C.L.), and the Department of Science and Technology–Science and Engineering Research Board Grant SB/YS/LS-215/2013.

Funding

  • Tata Institute of Fundamental Research (TIFR)

    VAV
  • Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)

    JCL
  • DST-SERB Government of India

    SB/ YS/ LS-215/2013

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  • You are viewing the most recent version of this article.
  • previous version (October 23, 2019).

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Oct 2019410094
Nov 2019589191139
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Total 20191092341282
Jan 20204918138
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Total 2022261468343
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Aug 20241912739
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Total 20242111236447
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Total 20251602406486
Jan 20261230550
Feb 20262242332
Mar 20261532857
Apr 20261011055
Total 2026591166194
Total1793109892976
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Chemogenetic Activation of Excitatory Neurons Alters Hippocampal Neurotransmission in a Dose-Dependent Manner
Sthitapranjya Pati, Sonali S. Salvi, Mamata Kallianpur, Bhupesh Vaidya, Antara Banerjee, Sudipta Maiti, James P. Clement, Vidita A. Vaidya
eNeuro 23 October 2019, 6 (6) ENEURO.0124-19.2019; DOI: 10.1523/ENEURO.0124-19.2019

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Chemogenetic Activation of Excitatory Neurons Alters Hippocampal Neurotransmission in a Dose-Dependent Manner
Sthitapranjya Pati, Sonali S. Salvi, Mamata Kallianpur, Bhupesh Vaidya, Antara Banerjee, Sudipta Maiti, James P. Clement, Vidita A. Vaidya
eNeuro 23 October 2019, 6 (6) ENEURO.0124-19.2019; DOI: 10.1523/ENEURO.0124-19.2019
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Keywords

  • CA1
  • chemogenetic
  • CNO
  • DREADDs
  • hM3Dq
  • pharmacogenetic

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Novel Tools and Methods

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