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Research ArticleNew Research, Disorders of the Nervous System

Functional Assessment In Vivo of the Mouse Homolog of the Human Ala-9-Ser NHE6 Variant

Qing Ouyang, Lena Joesch-Cohen, Sasmita Mishra, Hasib A. Riaz, Michael Schmidt and Eric M. Morrow
eNeuro 1 November 2019, 6 (6) ENEURO.0046-19.2019; DOI: https://doi.org/10.1523/ENEURO.0046-19.2019
Qing Ouyang
1Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912
2Center for Translational Neuroscience, Robert J. and Nancy D. Carney Institute for Brain Science and Brown Institute for Translational Science, Brown University, Providence, RI 02912
3Developmental Disorders Genetics Research Program, Emma Pendleton Bradley Hospital, East Providence, RI 02915
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Lena Joesch-Cohen
1Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912
4Hassenfeld Child Health Innovation Institute, Brown University, Providence, RI 02912
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Sasmita Mishra
1Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912
2Center for Translational Neuroscience, Robert J. and Nancy D. Carney Institute for Brain Science and Brown Institute for Translational Science, Brown University, Providence, RI 02912
3Developmental Disorders Genetics Research Program, Emma Pendleton Bradley Hospital, East Providence, RI 02915
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Hasib A. Riaz
1Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912
2Center for Translational Neuroscience, Robert J. and Nancy D. Carney Institute for Brain Science and Brown Institute for Translational Science, Brown University, Providence, RI 02912
3Developmental Disorders Genetics Research Program, Emma Pendleton Bradley Hospital, East Providence, RI 02915
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Michael Schmidt
1Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912
2Center for Translational Neuroscience, Robert J. and Nancy D. Carney Institute for Brain Science and Brown Institute for Translational Science, Brown University, Providence, RI 02912
3Developmental Disorders Genetics Research Program, Emma Pendleton Bradley Hospital, East Providence, RI 02915
4Hassenfeld Child Health Innovation Institute, Brown University, Providence, RI 02912
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Eric M. Morrow
1Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912
2Center for Translational Neuroscience, Robert J. and Nancy D. Carney Institute for Brain Science and Brown Institute for Translational Science, Brown University, Providence, RI 02912
3Developmental Disorders Genetics Research Program, Emma Pendleton Bradley Hospital, East Providence, RI 02915
4Hassenfeld Child Health Innovation Institute, Brown University, Providence, RI 02912
5Department of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University, Providence, RI 02912
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0046-19.2019
PubMed 
31676550
Published By 
Society for Neuroscience
History 
  • Received February 6, 2019
  • Revision received October 24, 2019
  • Accepted October 30, 2019
  • Published online November 1, 2019.
Copyright & Usage 
Copyright © 2019 Ouyang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Qing Ouyang1,2,3,
  2. Lena Joesch-Cohen1,4,
  3. Sasmita Mishra1,2,3,
  4. Hasib A. Riaz1,2,3,
  5. Michael Schmidt1,2,3,4 and
  6. Eric M. Morrow1,2,3,4,5
  1. 1Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912
  2. 2Center for Translational Neuroscience, Robert J. and Nancy D. Carney Institute for Brain Science and Brown Institute for Translational Science, Brown University, Providence, RI 02912
  3. 3Developmental Disorders Genetics Research Program, Emma Pendleton Bradley Hospital, East Providence, RI 02915
  4. 4Hassenfeld Child Health Innovation Institute, Brown University, Providence, RI 02912
  5. 5Department of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University, Providence, RI 02912
  1. Correspondence should be addressed to Eric M. Morrow at Eric_morrow{at}brown.edu.
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Author contributions

  1. Author contributions: Q.O., L.J.-C., and E.M.M. designed research; Q.O., L.J.-C., S.M., H.A.R., M.S., and E.M.M. performed research; Q.O., L.J.-C., S.M., M.S., and E.M.M. analyzed data; Q.O., L.J.-C., and E.M.M. wrote the paper.

View Abstract

Disclosures

  • The authors declare no competing financial interests.

  • This research was supported in part by National Institutes of Health/National Institute of Mental Health Grants R01-MH-102418, R01-MH-105442, and R21-MH-115392; a General Research Grant from the Angelman Syndrome Foundation; and the Hassenfeld Child Health Innovation Institute at Brown University (E.M.M.); and a Hassenfeld Summer Scholar Award (L.J.-C.). The Mouse Transgenic and Gene Targeting Facility at Brown University is supported by National Institutes of Health/National Institute of General Medical Sciences Grant P30-GM1-03410. The Opera Phenix High Content Screening System in the Center to Advance Predictive Biology at Brown University is supported by National Institutes of Health/National Institute of Environmental Health Sciences Grant U01-ES-028184, National Science Foundation EPSCoR Award 1655221, and a generous gift by Donna McGraw Weiss (1989) and Jason Weiss.

Funding

  • HHS | NIH | National Institute of Mental Health (NIMH)

    R01MH102418; R01MH105442; R21MH115392
  • Angelman Syndrome Foundation (ASF)

  • Hassenfeld Child Health Innovation Institute

  • HHS | NIH | National Institute of General Medical Sciences (NIGMS)

    P30GM103410
  • HHS | NIH | National Institute of Environmental Health Sciences (NIEHS)

    U01ES028184
  • National Science Foundation (NSF)

    EPSCoR 1655221
  • Donna McGraw Weiss and Jason Weiss

Other Version

  • previous version (November 01, 2019).
  • You are viewing the most recent version of this article.

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Nov 2019257195
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Total 2019348133133
Jan 2020466720
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Functional Assessment In Vivo of the Mouse Homolog of the Human Ala-9-Ser NHE6 Variant
Qing Ouyang, Lena Joesch-Cohen, Sasmita Mishra, Hasib A. Riaz, Michael Schmidt, Eric M. Morrow
eNeuro 1 November 2019, 6 (6) ENEURO.0046-19.2019; DOI: 10.1523/ENEURO.0046-19.2019

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Functional Assessment In Vivo of the Mouse Homolog of the Human Ala-9-Ser NHE6 Variant
Qing Ouyang, Lena Joesch-Cohen, Sasmita Mishra, Hasib A. Riaz, Michael Schmidt, Eric M. Morrow
eNeuro 1 November 2019, 6 (6) ENEURO.0046-19.2019; DOI: 10.1523/ENEURO.0046-19.2019
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Keywords

  • Christianson syndrome
  • endosomes
  • genetics
  • SLC9A6
  • variant of unknown significance

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