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Research ArticleNew Research, Disorders of the Nervous System

Temporal Sequences of Synapse Disintegration Triggered by Afferent Axon Transection, Time-Lapse Imaging Study of Presynaptic and Postsynaptic Molecules

Takusei Cho, Yutaro Kashiwagi and Shigeo Okabe
eNeuro 12 September 2019, 6 (5) ENEURO.0459-18.2019; https://doi.org/10.1523/ENEURO.0459-18.2019
Takusei Cho
Department of Cellular Neurobiology, Graduate School of Medicine, the University of Tokyo, Tokyo 113-0033, Japan
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Yutaro Kashiwagi
Department of Cellular Neurobiology, Graduate School of Medicine, the University of Tokyo, Tokyo 113-0033, Japan
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Shigeo Okabe
Department of Cellular Neurobiology, Graduate School of Medicine, the University of Tokyo, Tokyo 113-0033, Japan
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0459-18.2019
PubMed 
31515235
Published By 
Society for Neuroscience
History 
  • Received November 22, 2018
  • Revision received July 22, 2019
  • Accepted July 30, 2019
  • Published online September 12, 2019.
Copyright & Usage 
Copyright © 2019 Cho et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Takusei Cho,
  2. Yutaro Kashiwagi and
  3. Shigeo Okabe
  1. Department of Cellular Neurobiology, Graduate School of Medicine, the University of Tokyo, Tokyo 113-0033, Japan
  1. Correspondence should be addressed to Shigeo Okabe at okabe{at}m.u-tokyo.ac.jp.
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Author contributions

  1. Author contributions: T.C., Y.K., and S.O. designed research; T.C. and Y.K. performed research; T.C. and Y.K. analyzed data; T.C., Y.K., and S.O. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This study was supported by JSPS Grants-in-Aid for Scientific Research (17H01387 and 18H04727 to S.O.), Core Research for Evolutional Science and Technology from the Japan Science and Technology Agency (JPMJCR14W2 to S.O.), the Project for Elucidating and Controlling Mechanisms of Aging and Longevity from the Japan Agency for Medical Research and Development (17gm5010003 to S.O.) and the UTokyo Center for Integrative Science of Human Behavior (CiSHuB).

Funding

  • Ministry of Education, Culture, Sports, Science, and Technology (MEXT)

    17H01387; 18H04727
  • Japan Science and Technology Agency (JST)

    JPMJCR14W2
  • Japan Agency for Medical Research and Development (AMED)

    17gm5010003
  • Center for Integrative Science of Human Behavior

Other Version

  • You are viewing the most recent version of this article.
  • previous version (September 12, 2019).

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Total62450421030
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eneuro: 6 (5)
eNeuro
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September/October 2019
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Temporal Sequences of Synapse Disintegration Triggered by Afferent Axon Transection, Time-Lapse Imaging Study of Presynaptic and Postsynaptic Molecules
Takusei Cho, Yutaro Kashiwagi, Shigeo Okabe
eNeuro 12 September 2019, 6 (5) ENEURO.0459-18.2019; DOI: 10.1523/ENEURO.0459-18.2019

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Temporal Sequences of Synapse Disintegration Triggered by Afferent Axon Transection, Time-Lapse Imaging Study of Presynaptic and Postsynaptic Molecules
Takusei Cho, Yutaro Kashiwagi, Shigeo Okabe
eNeuro 12 September 2019, 6 (5) ENEURO.0459-18.2019; DOI: 10.1523/ENEURO.0459-18.2019
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Keywords

  • dendritic spine
  • hippocampus
  • live imaging
  • NMDA receptor
  • synaptic plasticity
  • traumatic brain injury

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