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Research ArticleNew Research, Disorders of the Nervous System

Apparent Genetic Rescue of Adult Shank3 Exon 21 Insertion Mutation Mice Tempered by Appropriate Control Experiments

Haley E. Speed, Mehreen Kouser, Zhong Xuan, Shunan Liu, Anne Duong and Craig M. Powell
eNeuro 26 August 2019, 6 (5) ENEURO.0317-19.2019; https://doi.org/10.1523/ENEURO.0317-19.2019
Haley E. Speed
1Department of Neurobiology, University of Alabama at Birmingham School of Medicine, Birmingham 35294-2182, AL
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Mehreen Kouser
1Department of Neurobiology, University of Alabama at Birmingham School of Medicine, Birmingham 35294-2182, AL
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Zhong Xuan
1Department of Neurobiology, University of Alabama at Birmingham School of Medicine, Birmingham 35294-2182, AL
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Shunan Liu
1Department of Neurobiology, University of Alabama at Birmingham School of Medicine, Birmingham 35294-2182, AL
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Anne Duong
1Department of Neurobiology, University of Alabama at Birmingham School of Medicine, Birmingham 35294-2182, AL
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Craig M. Powell
1Department of Neurobiology, University of Alabama at Birmingham School of Medicine, Birmingham 35294-2182, AL
2Civitan International Research Center at UAB, Birmingham 35294-2182, AL
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0317-19.2019
PubMed 
31451607
Published By 
Society for Neuroscience
History 
  • Received August 9, 2019
  • Revision received August 19, 2019
  • Accepted August 22, 2019
  • Published online August 26, 2019.
Copyright & Usage 
Copyright © 2019 Speed et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Haley E. Speed1,*,
  2. Mehreen Kouser1,*,
  3. Zhong Xuan1,
  4. Shunan Liu1,
  5. Anne Duong1 and
  6. Craig M. Powell1,2
  1. 1Department of Neurobiology, University of Alabama at Birmingham School of Medicine, Birmingham 35294-2182, AL
  2. 2Civitan International Research Center at UAB, Birmingham 35294-2182, AL
  1. Correspondence should be addressed to Craig M. Powell at craigpow{at}uab.edu.
  • H. E. Speed’s present address: Center for Integrative Brain Research, Seattle Children’s Research Institute, Seattle, WA.

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Author contributions

  1. Author contributions: H.E.S., M.K., Z.X., and C.M.P. designed research; H.E.S., M.K., Z.X., S.L., and A.D. performed research; H.E.S., M.K., and C.M.P. analyzed data; H.E.S. and C.M.P. wrote the paper; C.M.P. contributed unpublished reagents/analytic tools.

  2. ↵* H.E.S. and M.K. contributed equally to this work.

  • H. E. Speed’s present address: Center for Integrative Brain Research, Seattle Children’s Research Institute, Seattle, WA.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by United States Department of Health and Human Services National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health and Human Development Grants R01HD069560 and R01HD069560-S1 (to C.M.P.), Autism Speaks (Autism Speaks Inc.) Grants (to C.M.P), Autism Speaks Grants (7666 to C.M.P, 7898 to H.E.S.) Autism Science Foundation Pre-doctoral Fellowship (to C.O.E.), The Hartwell Foundation (C.M.P.), Ed and Sue Rose Distinguished Professorship in Neurology (C.M.P.), BRAINS for Autism (C.M.P.), Virginia B. Spencer Endowed Chair at UAB (C.M.P.), and Dr. Clay Heighten and Dr. Debra Caudy (C.M.P.). C.M.P. has accepted travel funds and honoraria to speak once at each of the following companies: Psychogenics, Inc.; Astra-Zeneca; Roche; Pfizer; and Dainippon Sumitomo Pharma Co. C.M.P. also has investigator-initiated grant funding for clinical research with Novartis.

Funding

  • HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

    R01HD069560; R01HD069560-S1
  • Autism Speaks (Autism Speaks Inc.)

  • Autism Science Foundation (ASF)

  • The Hartwell Foundation

  • Ed & Sue Rose Distinguished Professorship in Neurology

  • BRAINS for Autism

  • Drs. Clay Heighten and Debra Caudy

Other Version

  • You are viewing the most recent version of this article.
  • previous version (August 26, 2019).

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Article usage: August 2019 to March 2026

AbstractFullPdf
Aug 2019118042
Oct 20198115467
Nov 20194511926
Dec 2019217018
Total 2019265343153
Jan 2020167823
Feb 202096824
Mar 2020117718
May 202074718
Jun 202087218
Jul 20203428
Aug 202045923
Sep 202045725
Oct 202024318
Nov 202045221
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Total 202070669211
Jan 202105916
Feb 20212435
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Apr 202126010
May 202135519
Jun 202126120
Jul 202125012
Aug 202177220
Sep 202114510
Oct 202125524
Nov 202125126
Dec 202125019
Total 202127667204
Jan 202235615
Feb 202276436
Mar 20221349
Apr 202244816
May 202218031
Jun 202215316
Jul 202244215
Aug 202203713
Sep 202222715
Oct 202223115
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Dec 202223816
Total 202228550218
Jan 202303214
Feb 20231294
Mar 20230366
Apr 20232443
May 202313515
Jun 202315212
Jul 202346123
Aug 202334121
Sep 202334410
Oct 2023013210
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Dec 2023116728
Total 202336896154
Jan 202436214
Feb 20247407
Mar 202494521
Apr 20241211423
May 202455518
Jun 202436217
Jul 202414418
Aug 2024104214
Sep 202435213
Oct 202444518
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Total 202462644185
Jan 202536318
Feb 2025145617
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May 20252483
Jun 202512729
Jul 2025186417
Aug 202566223
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Dec 2025198632
Total 2025112800181
Jan 2026178822
Feb 20261614323
Mar 2026163
Total 20263423748
Total63448061354
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eneuro: 6 (5)
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September/October 2019
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Apparent Genetic Rescue of Adult Shank3 Exon 21 Insertion Mutation Mice Tempered by Appropriate Control Experiments
Haley E. Speed, Mehreen Kouser, Zhong Xuan, Shunan Liu, Anne Duong, Craig M. Powell
eNeuro 26 August 2019, 6 (5) ENEURO.0317-19.2019; DOI: 10.1523/ENEURO.0317-19.2019

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Apparent Genetic Rescue of Adult Shank3 Exon 21 Insertion Mutation Mice Tempered by Appropriate Control Experiments
Haley E. Speed, Mehreen Kouser, Zhong Xuan, Shunan Liu, Anne Duong, Craig M. Powell
eNeuro 26 August 2019, 6 (5) ENEURO.0317-19.2019; DOI: 10.1523/ENEURO.0317-19.2019
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Keywords

  • autism
  • Cre-recombinase
  • reversal
  • Shank3
  • tamoxifen

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