Skip to main content

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Blog
    • Collections
    • Podcast
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • ABOUT
    • Overview
    • Editorial Board
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
  • SUBMIT

User menu

Search

  • Advanced search
eNeuro
eNeuro

Advanced Search

 

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Blog
    • Collections
    • Podcast
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • ABOUT
    • Overview
    • Editorial Board
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
  • SUBMIT
PreviousNext
Research ArticleNew Research, Disorders of the Nervous System

Nuclear Receptor Nr4a1 Regulates Striatal Striosome Development and Dopamine D1 Receptor Signaling

Maria-Daniela Cirnaru, Chiara Melis, Tomas Fanutza, Swati Naphade, Kizito-Tshitoko Tshilenge, Brian S. Muntean, Kirill A. Martemyanov, Joshua L. Plotkin, Lisa M. Ellerby and Michelle E. Ehrlich
eNeuro 20 September 2019, 6 (5) ENEURO.0305-19.2019; https://doi.org/10.1523/ENEURO.0305-19.2019
Maria-Daniela Cirnaru
1Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York 10029
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Chiara Melis
1Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York 10029
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Chiara Melis
Tomas Fanutza
1Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York 10029
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Swati Naphade
2The Buck Institute for Research on Aging, Novato, California 94945
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kizito-Tshitoko Tshilenge
2The Buck Institute for Research on Aging, Novato, California 94945
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Brian S. Muntean
3Department of Neuroscience, The Scripps Research Institute, Jupiter, Florida 33458
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kirill A. Martemyanov
3Department of Neuroscience, The Scripps Research Institute, Jupiter, Florida 33458
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Kirill A. Martemyanov
Joshua L. Plotkin
4Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, New York 11794
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lisa M. Ellerby
2The Buck Institute for Research on Aging, Novato, California 94945
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michelle E. Ehrlich
1Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York 10029
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.1523/ENEURO.0305-19.2019
PubMed 
31541002
Published By 
Society for Neuroscience
History 
  • Received August 2, 2019
  • Revision received August 28, 2019
  • Accepted August 29, 2019
  • Published online September 20, 2019.
Copyright & Usage 
Copyright © 2019 Cirnaru et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Maria-Daniela Cirnaru1,*,
  2. Chiara Melis1,*,
  3. Tomas Fanutza1,
  4. Swati Naphade2,
  5. Kizito-Tshitoko Tshilenge2,
  6. Brian S. Muntean3,
  7. Kirill A. Martemyanov3,
  8. Joshua L. Plotkin4,
  9. Lisa M. Ellerby2 and
  10. Michelle E. Ehrlich1
  1. 1Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York 10029
  2. 2The Buck Institute for Research on Aging, Novato, California 94945
  3. 3Department of Neuroscience, The Scripps Research Institute, Jupiter, Florida 33458
  4. 4Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, New York 11794
  1. Correspondence should be addressed to Michelle E. Ehrlich at Michelle.ehrlich{at}mssm.edu.
View Full Text

Author contributions

  1. Author contributions: M.-D.C., C.M., T.F., S.N., K.A.M., J.L.P., L.M.E., and M.E.E. designed research; M.-D.C., C.M., T.F., S.N., K.-T.T., and B.S.M. performed research; M.-D.C., C.M., T.F., S.N., K.-T.T., B.S.M., K.A.M., and J.L.P. analyzed data; M.-D.C., B.S.M., K.A.M., J.L.P., L.M.E., and M.E.E. wrote the paper.

  2. ↵* M.D.C. and C.M. contributed equally to this work.

Disclosures

  • The authors declare no competing financial interests.

  • This research was supported by the Collaborative Center for X-linked Dystonia Parkinsonism; and by Department of Health and Human Services | National Institutes of Health | National Institute of Neurological Disorders and Stroke Grant R01-NS-100529 (to L.M.E. and M.E.E.).

Funding

  • Collaborative center for X linked Dystonia Parkinsonim

  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    R01NS100529

Other Version

  • You are viewing the most recent version of this article.
  • previous version (September 20, 2019).

Online Impact

 

Article usage

Select a custom date range for the past year
E.g., 2025-12-16
to
E.g., 2025-12-16

Article usage: October 2019 to December 2025

AbstractFullPdf
Oct 2019350196114
Nov 2019729542
Dec 2019288330
Total 2019450374186
Jan 2020197634
Feb 2020196151
Mar 2020154021
May 202055439
Jun 202035427
Jul 202035633
Aug 202056842
Sep 202056763
Oct 202019755
Nov 202046857
Dec 202029549
Total 202081736471
Jan 202169347
Feb 202137417
Mar 202147021
Apr 202118020
May 202127123
Jun 202107822
Jul 202107924
Aug 202126920
Sep 202136427
Oct 202106829
Nov 202117137
Dec 202136418
Total 202125881305
Jan 202228033
Feb 20223438
Mar 202224814
Apr 202246321
May 202206243
Jun 202236120
Jul 202214817
Aug 202215318
Sep 202214721
Oct 202265234
Nov 202253920
Dec 202204824
Total 202228644273
Jan 202355029
Feb 202304915
Mar 202346015
Apr 202315519
May 202303917
Jun 20230537
Jul 202315215
Aug 202375029
Sep 202355513
Oct 202327126
Nov 2023155321
Dec 202336824
Total 202343655230
Jan 202425627
Feb 2024135034
Mar 202456138
Apr 2024126738
May 202447433
Jun 2024135621
Jul 202465533
Aug 202484625
Sep 202476542
Oct 202415924
Nov 202428540
Dec 202486829
Total 202481742384
Jan 2025167139
Feb 2025810420
Mar 202597421
Apr 202566820
May 202546413
Jun 202557824
Jul 2025117625
Aug 202596219
Sep 2025611219
Oct 202514629
Nov 2025179325
Dec 20251428
Total 2025106906242
Total81449382091
Back to top

In this issue

eneuro: 6 (5)
eNeuro
Vol. 6, Issue 5
September/October 2019
  • Table of Contents
  • Index by author
  • Ed Board (PDF)
Email

Thank you for sharing this eNeuro article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Nuclear Receptor Nr4a1 Regulates Striatal Striosome Development and Dopamine D1 Receptor Signaling
(Your Name) has forwarded a page to you from eNeuro
(Your Name) thought you would be interested in this article in eNeuro.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Citation Tools
Nuclear Receptor Nr4a1 Regulates Striatal Striosome Development and Dopamine D1 Receptor Signaling
Maria-Daniela Cirnaru, Chiara Melis, Tomas Fanutza, Swati Naphade, Kizito-Tshitoko Tshilenge, Brian S. Muntean, Kirill A. Martemyanov, Joshua L. Plotkin, Lisa M. Ellerby, Michelle E. Ehrlich
eNeuro 20 September 2019, 6 (5) ENEURO.0305-19.2019; DOI: 10.1523/ENEURO.0305-19.2019

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Share
Nuclear Receptor Nr4a1 Regulates Striatal Striosome Development and Dopamine D1 Receptor Signaling
Maria-Daniela Cirnaru, Chiara Melis, Tomas Fanutza, Swati Naphade, Kizito-Tshitoko Tshilenge, Brian S. Muntean, Kirill A. Martemyanov, Joshua L. Plotkin, Lisa M. Ellerby, Michelle E. Ehrlich
eNeuro 20 September 2019, 6 (5) ENEURO.0305-19.2019; DOI: 10.1523/ENEURO.0305-19.2019
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Significance Statement
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Footnotes
    • References
    • Synthesis
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • dopamine receptor D1
  • ERK
  • Nr4a1
  • signal
  • striosome
  • transduction

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

New Research

  • A Very Fast Time Scale of Human Motor Adaptation: Within Movement Adjustments of Internal Representations during Reaching
  • Optogenetic Activation of β-Endorphin Terminals in the Medial Preoptic Nucleus Regulates Female Sexual Receptivity
  • Hsc70 Ameliorates the Vesicle Recycling Defects Caused by Excess α-Synuclein at Synapses
Show more New Research

Disorders of the Nervous System

  • Altered PI3K/mTOR signaling within the forebrain leads to respiratory deficits in a mouse model of epilepsy
  • Lack of ADAP1/Centaurin-α1 Ameliorates Cognitive Impairment and Neuropathological Hallmarks in a Mouse Model of Alzheimer's Disease
  • The Ventral Pallidum Innervates a Distinct Subset of Midbrain Dopamine Neurons
Show more Disorders of the Nervous System

Subjects

  • Disorders of the Nervous System
  • Home
  • Alerts
  • Follow SFN on BlueSky
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Latest Articles
  • Issue Archive
  • Blog
  • Browse by Topic

Information

  • For Authors
  • For the Media

About

  • About the Journal
  • Editorial Board
  • Privacy Notice
  • Contact
  • Feedback
(eNeuro logo)
(SfN logo)

Copyright © 2025 by the Society for Neuroscience.
eNeuro eISSN: 2373-2822

The ideas and opinions expressed in eNeuro do not necessarily reflect those of SfN or the eNeuro Editorial Board. Publication of an advertisement or other product mention in eNeuro should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in eNeuro.