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Research ArticleNew Research, Disorders of the Nervous System

Bursts with High and Low Load of Epileptiform Spikes Show Context-Dependent Correlations in Epileptic Mice

Katharina Heining, Antje Kilias, Philipp Janz, Ute Häussler, Arvind Kumar, Carola A. Haas and Ulrich Egert
eNeuro 16 August 2019, 6 (5) ENEURO.0299-18.2019; https://doi.org/10.1523/ENEURO.0299-18.2019
Katharina Heining
1Biomicrotechnology, Department of Microsystems Engineering - IMTEK, Faculty of Engineering, University of Freiburg, Freiburg 79110, Germany
2Bernstein Center Freiburg, University of Freiburg, Freiburg 79104, Germany
3Faculty of Biology, University of Freiburg, Freiburg 79104, Germany
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Antje Kilias
1Biomicrotechnology, Department of Microsystems Engineering - IMTEK, Faculty of Engineering, University of Freiburg, Freiburg 79110, Germany
2Bernstein Center Freiburg, University of Freiburg, Freiburg 79104, Germany
3Faculty of Biology, University of Freiburg, Freiburg 79104, Germany
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Philipp Janz
3Faculty of Biology, University of Freiburg, Freiburg 79104, Germany
4Experimental Epilepsy Research, Department of Neurosurgery, Medical Center, University of Freiburg, Freiburg 79106, Germany
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Ute Häussler
4Experimental Epilepsy Research, Department of Neurosurgery, Medical Center, University of Freiburg, Freiburg 79106, Germany
5BrainLinks-BrainTools Cluster of Excellence, University of Freiburg, Freiburg 79110, Germany
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Arvind Kumar
2Bernstein Center Freiburg, University of Freiburg, Freiburg 79104, Germany
6Computational Science and Technology, School of Electrical Engineering and Computer Science, KTH Royal Institute of Technology, Stockholm 11428, Sweden
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Carola A. Haas
2Bernstein Center Freiburg, University of Freiburg, Freiburg 79104, Germany
4Experimental Epilepsy Research, Department of Neurosurgery, Medical Center, University of Freiburg, Freiburg 79106, Germany
5BrainLinks-BrainTools Cluster of Excellence, University of Freiburg, Freiburg 79110, Germany
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Ulrich Egert
1Biomicrotechnology, Department of Microsystems Engineering - IMTEK, Faculty of Engineering, University of Freiburg, Freiburg 79110, Germany
2Bernstein Center Freiburg, University of Freiburg, Freiburg 79104, Germany
5BrainLinks-BrainTools Cluster of Excellence, University of Freiburg, Freiburg 79110, Germany
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0299-18.2019
PubMed 
31420348
Published By 
Society for Neuroscience
History 
  • Received July 30, 2018
  • Revision received June 12, 2019
  • Accepted June 27, 2019
  • Published online August 16, 2019.
Copyright & Usage 
Copyright © 2019 Heining et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Katharina Heining1,2,3,
  2. Antje Kilias1,2,3,
  3. Philipp Janz3,4,
  4. Ute Häussler4,5,
  5. Arvind Kumar2,6,
  6. Carola A. Haas2,4,5 and
  7. Ulrich Egert1,2,5
  1. 1Biomicrotechnology, Department of Microsystems Engineering - IMTEK, Faculty of Engineering, University of Freiburg, Freiburg 79110, Germany
  2. 2Bernstein Center Freiburg, University of Freiburg, Freiburg 79104, Germany
  3. 3Faculty of Biology, University of Freiburg, Freiburg 79104, Germany
  4. 4Experimental Epilepsy Research, Department of Neurosurgery, Medical Center, University of Freiburg, Freiburg 79106, Germany
  5. 5BrainLinks-BrainTools Cluster of Excellence, University of Freiburg, Freiburg 79110, Germany
  6. 6Computational Science and Technology, School of Electrical Engineering and Computer Science, KTH Royal Institute of Technology, Stockholm 11428, Sweden
  1. Correspondence should be addressed to Ulrich Egert at egert{at}imtek.uni-freiburg.de.
View Full Text

Author contributions

  1. Author contributions: K.H., A. Kilias, P.J., and U.H. performed research; K.H. contributed unpublished reagents/analytic tools; K.H. analyzed data; K.H. and U.E. wrote the paper; A. Kumar, C.A.H., and U.E. designed research.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the German Research Foundation as part of the Cluster of Excellence BrainLinks-BrainTools within the framework of the German Excellence Initiative (Grant EXC 1086, to U.E., A. Kumar, and C.A.H.) and through Grant INST 39/963-1 FUGG (bwForCluster NEMO), the State of Baden-Wuerttemberg through bwHPC, and by the Federal Ministry of Education and Research (BMBF) Grants FKZ 1GQ0830 and 16PGF0070 (to U.E.), co-financed by the European Union/European Regional Development Fund (TIGER, A31). The article processing charge was funded by the German Research Foundation (DFG) and the University of Freiburg in the funding programme Open Access Publishing.

Funding

  • Bundesministerium für Bildung und Forschung (BMBF)

    FKZ 1GQ0830
  • European Union/European Development Fund

    A31
  • Deutsche Forschungsgemeinschaft (DFG)

    EXC1086; INST 39/963-1 FUGG
  • State of Baden-Wuerttemberg

    bwHPC
  • Bundesministerim für Bildung und Forschung (BMBF)

    FKZ 16PGF0070
  • Carl-Zeiss-Stiftung (Carl Zeiss Stiftung)

    „Computational Neuroscience of Brain Disease

Other Version

  • You are viewing the most recent version of this article.
  • previous version (August 16, 2019).

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Aug 2019286085
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Total 2019390218158
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Total 2025991163267
Jan 20261116625
Feb 20261418022
Mar 20260231
Total 20262536948
Total75854111564
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Bursts with High and Low Load of Epileptiform Spikes Show Context-Dependent Correlations in Epileptic Mice
Katharina Heining, Antje Kilias, Philipp Janz, Ute Häussler, Arvind Kumar, Carola A. Haas, Ulrich Egert
eNeuro 16 August 2019, 6 (5) ENEURO.0299-18.2019; DOI: 10.1523/ENEURO.0299-18.2019

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Bursts with High and Low Load of Epileptiform Spikes Show Context-Dependent Correlations in Epileptic Mice
Katharina Heining, Antje Kilias, Philipp Janz, Ute Häussler, Arvind Kumar, Carola A. Haas, Ulrich Egert
eNeuro 16 August 2019, 6 (5) ENEURO.0299-18.2019; DOI: 10.1523/ENEURO.0299-18.2019
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Keywords

  • electrographic seizures
  • epileptic spikes
  • epileptiform activity
  • hippocampus
  • interictal activity
  • mesial temporal lobe epilepsy

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