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Research ArticleNew Research, Neuronal Excitability

Transcranial Direct Current Stimulation (tDCS) Induces Adrenergic Receptor-Dependent Microglial Morphological Changes in Mice

Tsuneko Mishima, Terumi Nagai, Kazuko Yahagi, Sonam Akther, Yuki Oe, Hiromu Monai, Shinichi Kohsaka and Hajime Hirase
eNeuro 23 August 2019, 6 (5) ENEURO.0204-19.2019; https://doi.org/10.1523/ENEURO.0204-19.2019
Tsuneko Mishima
1Laboratory for Neuron-Glia Circuitry, RIKEN Center for Brain Science, Wako 351-0198, Japan
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Terumi Nagai
1Laboratory for Neuron-Glia Circuitry, RIKEN Center for Brain Science, Wako 351-0198, Japan
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Kazuko Yahagi
1Laboratory for Neuron-Glia Circuitry, RIKEN Center for Brain Science, Wako 351-0198, Japan
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Sonam Akther
1Laboratory for Neuron-Glia Circuitry, RIKEN Center for Brain Science, Wako 351-0198, Japan
2Brain and Body System Science Institute, Saitama University, Saitama 338-8570, Japan
3Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark
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Yuki Oe
1Laboratory for Neuron-Glia Circuitry, RIKEN Center for Brain Science, Wako 351-0198, Japan
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Hiromu Monai
1Laboratory for Neuron-Glia Circuitry, RIKEN Center for Brain Science, Wako 351-0198, Japan
4Faculty of Core Research Natural Science Division, Ochanomizu University, Tokyo 112-8610, Japan
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Shinichi Kohsaka
5National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira 187-0031, Japan
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Hajime Hirase
1Laboratory for Neuron-Glia Circuitry, RIKEN Center for Brain Science, Wako 351-0198, Japan
2Brain and Body System Science Institute, Saitama University, Saitama 338-8570, Japan
3Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0204-19.2019
PubMed 
31444225
Published By 
Society for Neuroscience
History 
  • Received May 29, 2019
  • Revision received August 5, 2019
  • Accepted August 19, 2019
  • Published online August 23, 2019.
Copyright & Usage 
Copyright © 2019 Mishima et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Tsuneko Mishima1,
  2. Terumi Nagai1,
  3. Kazuko Yahagi1,
  4. Sonam Akther1,2,3,
  5. Yuki Oe1,
  6. Hiromu Monai1,4,
  7. Shinichi Kohsaka5 and
  8. Hajime Hirase1,2,3
  1. 1Laboratory for Neuron-Glia Circuitry, RIKEN Center for Brain Science, Wako 351-0198, Japan
  2. 2Brain and Body System Science Institute, Saitama University, Saitama 338-8570, Japan
  3. 3Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark
  4. 4Faculty of Core Research Natural Science Division, Ochanomizu University, Tokyo 112-8610, Japan
  5. 5National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira 187-0031, Japan
  1. Correspondence should be addressed to Tsuneko Mishima at Tsuneko.mishima{at}riken.jp or Hajime Hirase at hirase{at}sund.ku.dk.
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Author contributions

  1. Author contributions: T.M., S.K., and H.H. designed research; T.M., T.N., K.Y., S.A., Y.O., and H.M. performed research; T.M., T.N., and K.Y. analyzed data; T.M. and H.H. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the RIKEN Brain Science Institute and Center for Brain Science; KAKENHI Grants 16H01888, 18H05150, and 18K14859; and Human Frontier Science Program Grant RGP0036/2014.

Funding

  • JSPS KAKENHI

    16H01888; 18H05150; 18K14859
  • HFSP

    RGP0036/2014

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  • You are viewing the most recent version of this article.
  • previous version (August 23, 2019).

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Aug 20194870134
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Total 2019631686301
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Total 202542385154
Total119083592311
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Transcranial Direct Current Stimulation (tDCS) Induces Adrenergic Receptor-Dependent Microglial Morphological Changes in Mice
Tsuneko Mishima, Terumi Nagai, Kazuko Yahagi, Sonam Akther, Yuki Oe, Hiromu Monai, Shinichi Kohsaka, Hajime Hirase
eNeuro 23 August 2019, 6 (5) ENEURO.0204-19.2019; DOI: 10.1523/ENEURO.0204-19.2019

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Transcranial Direct Current Stimulation (tDCS) Induces Adrenergic Receptor-Dependent Microglial Morphological Changes in Mice
Tsuneko Mishima, Terumi Nagai, Kazuko Yahagi, Sonam Akther, Yuki Oe, Hiromu Monai, Shinichi Kohsaka, Hajime Hirase
eNeuro 23 August 2019, 6 (5) ENEURO.0204-19.2019; DOI: 10.1523/ENEURO.0204-19.2019
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Keywords

  • Iba1
  • in vivo
  • microglia
  • norepinephrine
  • tDCS
  • two-photon imaging

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