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Research ArticleNew Research, Disorders of the Nervous System

Long-Distance Axon Regeneration Promotes Recovery of Diaphragmatic Respiratory Function after Spinal Cord Injury

Mark W. Urban, Biswarup Ghosh, Cole G. Block, Laura R. Strojny, Brittany A. Charsar, Miguel Goulão, Sreeya S. Komaravolu, George M. Smith, Megan C. Wright, Shuxin Li and Angelo C. Lepore
eNeuro 19 August 2019, 6 (5) ENEURO.0096-19.2019; https://doi.org/10.1523/ENEURO.0096-19.2019
Mark W. Urban
1Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107
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Biswarup Ghosh
1Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107
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  • ORCID record for Biswarup Ghosh
Cole G. Block
1Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107
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Laura R. Strojny
1Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107
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Brittany A. Charsar
1Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107
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Miguel Goulão
1Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107
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Sreeya S. Komaravolu
1Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107
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  • ORCID record for Sreeya S. Komaravolu
George M. Smith
2Department of Neuroscience, Shriners Hospitals for Pediatric Research Center, Temple University School of Medicine, Philadelphia, PA 19140
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Megan C. Wright
3Department of Biology, Arcadia University, Glenside, PA 19038
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Shuxin Li
2Department of Neuroscience, Shriners Hospitals for Pediatric Research Center, Temple University School of Medicine, Philadelphia, PA 19140
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Angelo C. Lepore
1Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0096-19.2019
PubMed 
31427403
Published By 
Society for Neuroscience
History 
  • Received March 15, 2019
  • Revision received June 11, 2019
  • Accepted June 14, 2019
  • Published online August 19, 2019.
Copyright & Usage 
Copyright © 2019 Urban et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Mark W. Urban1,^,
  2. Biswarup Ghosh1,^,
  3. Cole G. Block1,
  4. Laura R. Strojny1,
  5. Brittany A. Charsar1,
  6. Miguel Goulão1,
  7. Sreeya S. Komaravolu1,
  8. George M. Smith2,
  9. Megan C. Wright3,
  10. Shuxin Li2 and
  11. Angelo C. Lepore1
  1. 1Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107
  2. 2Department of Neuroscience, Shriners Hospitals for Pediatric Research Center, Temple University School of Medicine, Philadelphia, PA 19140
  3. 3Department of Biology, Arcadia University, Glenside, PA 19038
  1. Correspondence should be addressed to Angelo C. Lepore at angelo.lepore{at}jefferson.edu.
View Full Text

Author contributions

  1. Author contributions: M.W.U., B.G., C.G.B., L.R.S., S.L., and A.C.L. designed research; M.W.U., B.G., C.G.B., L.R.S., B.A.C., M.G., S.S.K., M.C.W., and A.C.L. performed research; M.W.U., B.G., C.G.B., L.R.S., B.A.C., M.G., S.S.K., M.C.W., and A.C.L. analyzed data; M.W.U. and A.C.L. wrote the paper; G.M.S. and S.L. contributed unpublished reagents/analytic tools.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by Department of Health and Human Services National Institutes of Health National Institute of Neurological Disorders and Stroke Grants 2R01NS079702-06 (to A.C.L.) and 1F30NS103436 (to B.A.C.), the Craig H. Neilsen Foundation Grant 476686 (to A.C.L.), and the Shriners Hospitals for Children Grant SHC-84051 (to G.M.S.).

  • ↵^ M.W.U. and B.G. share co-first authorship.

Funding

  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    2R01NS079702-06; 1F30NS103436
  • Craig H. Neilsen Foundation

    476686
  • Shriners Hospitals for Children

    SHC-84051

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  • You are viewing the most recent version of this article.
  • previous version (August 19, 2019).

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AbstractFullPdf
Aug 20193390116
Oct 20196613537
Nov 2019418127
Dec 2019167124
Total 2019462287204
Jan 2020167123
Feb 2020149327
Mar 20201412338
May 2020118349
Jun 2020109541
Jul 20201111729
Aug 202031171101
Sep 20201619746
Oct 20202212545
Nov 20201417240
Dec 20201315732
Total 20201721404471
Jan 20211813735
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May 2021137413
Jun 202197915
Jul 202187232
Aug 2021149622
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Total 20211751004254
Jan 20226607
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Apr 202234319
May 202265122
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Jul 202273811
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Jan 202313717
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Total 202378580222
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Jun 202497118
Jul 2024155122
Aug 202495218
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Total 202493673218
Jan 202576919
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Total 20251561165282
Jan 20262323824
Feb 20262836019
Mar 20264276
Total 20265562549
Total124862661914
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Long-Distance Axon Regeneration Promotes Recovery of Diaphragmatic Respiratory Function after Spinal Cord Injury
Mark W. Urban, Biswarup Ghosh, Cole G. Block, Laura R. Strojny, Brittany A. Charsar, Miguel Goulão, Sreeya S. Komaravolu, George M. Smith, Megan C. Wright, Shuxin Li, Angelo C. Lepore
eNeuro 19 August 2019, 6 (5) ENEURO.0096-19.2019; DOI: 10.1523/ENEURO.0096-19.2019

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Long-Distance Axon Regeneration Promotes Recovery of Diaphragmatic Respiratory Function after Spinal Cord Injury
Mark W. Urban, Biswarup Ghosh, Cole G. Block, Laura R. Strojny, Brittany A. Charsar, Miguel Goulão, Sreeya S. Komaravolu, George M. Smith, Megan C. Wright, Shuxin Li, Angelo C. Lepore
eNeuro 19 August 2019, 6 (5) ENEURO.0096-19.2019; DOI: 10.1523/ENEURO.0096-19.2019
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Keywords

  • cervical
  • diaphragm
  • phrenic
  • plasticity
  • Pten
  • sprouting

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