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Research ArticleNew Research, Cognition and Behavior

A Receptor Tyrosine Kinase Plays Separate Roles in Sensory Integration and Associative Learning in C. elegans

Glenn S. Wolfe, Vivian W. Tong, Emily Povse, Daniel M. Merritt, Gregory W. Stegeman, Stephane Flibotte and Derek van der Kooy
eNeuro 1 August 2019, 6 (4) ENEURO.0244-18.2019; https://doi.org/10.1523/ENEURO.0244-18.2019
Glenn S. Wolfe
1Institute of Medical Science, University of Toronto, Toronto, Ontario M5S 1A8, Canada
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Vivian W. Tong
2Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada
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Emily Povse
2Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada
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Daniel M. Merritt
1Institute of Medical Science, University of Toronto, Toronto, Ontario M5S 1A8, Canada
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Gregory W. Stegeman
3Department of Zoology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
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Stephane Flibotte
3Department of Zoology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
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Derek van der Kooy
1Institute of Medical Science, University of Toronto, Toronto, Ontario M5S 1A8, Canada
2Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0244-18.2019
PubMed 
31371455
Published By 
Society for Neuroscience
History 
  • Received June 18, 2018
  • Revision received July 17, 2019
  • Accepted July 25, 2019
  • Published online August 1, 2019.
Copyright & Usage 
Copyright © 2019 Wolfe et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Glenn S. Wolfe1,
  2. Vivian W. Tong2,
  3. Emily Povse2,
  4. Daniel M. Merritt1,
  5. Gregory W. Stegeman3,
  6. Stephane Flibotte3 and
  7. Derek van der Kooy1,2
  1. 1Institute of Medical Science, University of Toronto, Toronto, Ontario M5S 1A8, Canada
  2. 2Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada
  3. 3Department of Zoology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
  1. Correspondence should be addressed to Glenn S. Wolfe at Glenn.wolfe{at}utoronto.ca.
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Author contributions

  1. Author contributions: G.S.W. and D.v.d.K. designed research; G.S.W., V.W.T., E.P., D.M.M., and G.W.S. performed research; G.S.W. and S.F. analyzed data; G.S.W. and D.v.d.K. wrote the paper.

Disclosures

  • The authors declare no competing financial interests

  • This work was supported by Natural Sciences and Engineering Research Council of Canada (501100000038). Some strains were provided by the CGC, which is funded by NIH Office of Research Infrastructure Programs (P40 OD010440). Other strains were provided by the National Bioresource Project. We thank Dr. Takeshi Ishihara for providing the AIA rescue animals, Dr. Peter Roy for discussions and microinjection support, Dr. Karen Maxwell for the use of her laboratory space for PA14 assays, and the worm group in the van der Kooy laboratory for discussion and support. The genomic sequencing was provided by Canada’s Michael Smith Genome Sciences Center.

Funding

  • Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (NSERC)

Other Version

  • You are viewing the most recent version of this article.
  • previous version (August 01, 2019).

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Aug 2019655218174
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Total 202597903179
Jan 2026119614
Feb 20261417213
Mar 20261213035
Apr 202693323
Total 20264643185
Total114149411282
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A Receptor Tyrosine Kinase Plays Separate Roles in Sensory Integration and Associative Learning in C. elegans
Glenn S. Wolfe, Vivian W. Tong, Emily Povse, Daniel M. Merritt, Gregory W. Stegeman, Stephane Flibotte, Derek van der Kooy
eNeuro 1 August 2019, 6 (4) ENEURO.0244-18.2019; DOI: 10.1523/ENEURO.0244-18.2019

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A Receptor Tyrosine Kinase Plays Separate Roles in Sensory Integration and Associative Learning in C. elegans
Glenn S. Wolfe, Vivian W. Tong, Emily Povse, Daniel M. Merritt, Gregory W. Stegeman, Stephane Flibotte, Derek van der Kooy
eNeuro 1 August 2019, 6 (4) ENEURO.0244-18.2019; DOI: 10.1523/ENEURO.0244-18.2019
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Keywords

  • associative learning
  • C. elegans
  • chemotaxis
  • PA14
  • sensory integration

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