Figure 6. Decreases in accuracy grow over time with suppression of ACC and V1, but not dHC. Suppression effect size was calculated by subtracting accuracy of suppressed trials from non-suppressed trials. The size of the suppression effect increased significantly across days for V1 and ACC mice (Friedman’s, df = 15, χ2 = 62.4, p < 0.0001 and df = 15, χ2 = 25.7, p = 0.04, respectively), but not dHC mice. Differences in effect size were significant between groups during stages 3 and 4 (Kruskal–Wallis, df = 2, p = 0.002 and df = 2, p < 0.0001, respectively), with effect size in V1 exceeding that of ACC during stages 3 and 4 (Mann–Whitney, z = –2.7, p = 0.006 and z = –2.4, p = 0.02, respectively), and ACC exceeding that of dHC during stage 4 (Mann–Whitney, z = –2.4, p = 0.02).