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Research ArticleNew Research, Disorders of the Nervous System

3D Electron Microscopy Study of Synaptic Organization of the Normal Human Transentorhinal Cortex and Its Possible Alterations in Alzheimer’s Disease

M. Domínguez-Álvaro, M. Montero-Crespo, L. Blazquez-Llorca, J. DeFelipe and L. Alonso-Nanclares
eNeuro 19 June 2019, 6 (4) ENEURO.0140-19.2019; DOI: https://doi.org/10.1523/ENEURO.0140-19.2019
M. Domínguez-Álvaro
1Laboratorio Cajal de Circuitos Corticales, Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, Madrid 28223, Spain
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M. Montero-Crespo
1Laboratorio Cajal de Circuitos Corticales, Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, Madrid 28223, Spain
2Instituto Cajal, Consejo Superior de Investigaciones Científicas (CSIC), Madrid 28002, Spain
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L. Blazquez-Llorca
1Laboratorio Cajal de Circuitos Corticales, Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, Madrid 28223, Spain
3Departamento de Psicobiología, Facultad de Psicología, Universidad Nacional de Educación a Distancia (UNED), Madrid 28040, Spain
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J. DeFelipe
1Laboratorio Cajal de Circuitos Corticales, Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, Madrid 28223, Spain
2Instituto Cajal, Consejo Superior de Investigaciones Científicas (CSIC), Madrid 28002, Spain
4Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid 28031, Spain
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L. Alonso-Nanclares
1Laboratorio Cajal de Circuitos Corticales, Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, Madrid 28223, Spain
2Instituto Cajal, Consejo Superior de Investigaciones Científicas (CSIC), Madrid 28002, Spain
4Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid 28031, Spain
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0140-19.2019
PubMed 
31217195
Published By 
Society for Neuroscience
History 
  • Received April 11, 2019
  • Revision received May 23, 2019
  • Accepted May 27, 2019
  • Published online June 19, 2019.
Copyright & Usage 
Copyright © 2019 Domínguez-Álvaro et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. M. Domínguez-Álvaro1,
  2. M. Montero-Crespo1,2,
  3. L. Blazquez-Llorca1,3,
  4. J. DeFelipe1,2,4 and
  5. L. Alonso-Nanclares1,2,4
  1. 1Laboratorio Cajal de Circuitos Corticales, Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, Madrid 28223, Spain
  2. 2Instituto Cajal, Consejo Superior de Investigaciones Científicas (CSIC), Madrid 28002, Spain
  3. 3Departamento de Psicobiología, Facultad de Psicología, Universidad Nacional de Educación a Distancia (UNED), Madrid 28040, Spain
  4. 4Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid 28031, Spain
  1. Correspondence should be addressed to L. Alonso-Nanclares at aidil{at}cajal.csic.es.
View Full Text

Author contributions

  1. Author contributions: M.D.-A., M.M.-C., L.B.-L., and L.A.-N. performed research; M.D.-A. analyzed data; M.D.-A. and L.A.-N. wrote the paper; J.D. and L.A.-N. designed research.

View Abstract

Disclosures

  • The authors declare no competing financial interests.

  • This work was funded by grants from the “Ministerio de Ciencia, Innovación y Universidades” (grant PGC2018-094307-B-I00), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED, Spain, CB06/05/0066), the Alzheimer’s Association (ZEN-15-321663), and the European Union’s Horizon 2020 Research and Innovation Program under grant agreement No. 785907 (Human Brain Project, second specific grant agreement [SGA2]). M.M.-C. was awarded an FPU contract (14/02245) from the Spanish “Ministerio de Educación, Cultura y Deporte” (MECD).

Funding

  • Spanish Ministry of Economy and Competitiveness

    SAF 2015-66603-P
  • Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenrativas

    CB06/05/0066
  • Horizon 2020

    No. 785907
  • Alzheimer's Association

    ZEN-15-321663
  • Spanish Ministry of Education, Culture and Sport

    FPU 14/02245

Other Version

  • previous version (June 19, 2019).
  • You are viewing the most recent version of this article.

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Jun 20194140129
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3D Electron Microscopy Study of Synaptic Organization of the Normal Human Transentorhinal Cortex and Its Possible Alterations in Alzheimer’s Disease
M. Domínguez-Álvaro, M. Montero-Crespo, L. Blazquez-Llorca, J. DeFelipe, L. Alonso-Nanclares
eNeuro 19 June 2019, 6 (4) ENEURO.0140-19.2019; DOI: 10.1523/ENEURO.0140-19.2019

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3D Electron Microscopy Study of Synaptic Organization of the Normal Human Transentorhinal Cortex and Its Possible Alterations in Alzheimer’s Disease
M. Domínguez-Álvaro, M. Montero-Crespo, L. Blazquez-Llorca, J. DeFelipe, L. Alonso-Nanclares
eNeuro 19 June 2019, 6 (4) ENEURO.0140-19.2019; DOI: 10.1523/ENEURO.0140-19.2019
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Keywords

  • dementia
  • dendritic shafts
  • dendritic spines
  • FIB/SEM
  • synaptic morphology

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