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Research ArticleNew Research, Disorders of the Nervous System

New Concerns for Neurocognitive Function during Deep Space Exposures to Chronic, Low Dose-Rate, Neutron Radiation

Munjal M. Acharya, Janet E. Baulch, Peter M. Klein, Al Anoud D. Baddour, Lauren A. Apodaca, Eniko A. Kramár, Leila Alikhani, Camillo Garcia Jr, Maria C. Angulo, Raja S. Batra, Christine M. Fallgren, Thomas B. Borak, Craig E. L. Stark, Marcello A. Wood, Richard A. Britten, Ivan Soltesz and Charles L. Limoli
eNeuro 5 August 2019, 6 (4) ENEURO.0094-19.2019; https://doi.org/10.1523/ENEURO.0094-19.2019
Munjal M. Acharya
1Department of Radiation Oncology, University of California, Irvine, California 92697
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Janet E. Baulch
1Department of Radiation Oncology, University of California, Irvine, California 92697
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Peter M. Klein
2Department of Neurosurgery, Stanford University, California 94305
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Al Anoud D. Baddour
1Department of Radiation Oncology, University of California, Irvine, California 92697
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Lauren A. Apodaca
1Department of Radiation Oncology, University of California, Irvine, California 92697
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Eniko A. Kramár
3Department of Neurobiology and Behavior, University of California, Irvine, California 92697
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Leila Alikhani
1Department of Radiation Oncology, University of California, Irvine, California 92697
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Camillo Garcia Jr
1Department of Radiation Oncology, University of California, Irvine, California 92697
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Maria C. Angulo
1Department of Radiation Oncology, University of California, Irvine, California 92697
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Raja S. Batra
1Department of Radiation Oncology, University of California, Irvine, California 92697
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Christine M. Fallgren
4Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523
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Thomas B. Borak
4Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523
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Craig E. L. Stark
3Department of Neurobiology and Behavior, University of California, Irvine, California 92697
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Marcello A. Wood
3Department of Neurobiology and Behavior, University of California, Irvine, California 92697
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Richard A. Britten
5Department of Radiation Oncology, Eastern Virginia Medical School, Norfolk, Virginia 23507
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Ivan Soltesz
2Department of Neurosurgery, Stanford University, California 94305
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Charles L. Limoli
1Department of Radiation Oncology, University of California, Irvine, California 92697
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0094-19.2019
PubMed 
31383727
Published By 
Society for Neuroscience
History 
  • Received March 13, 2019
  • Revision received July 8, 2019
  • Accepted July 16, 2019
  • Published online August 5, 2019.
Copyright & Usage 
Copyright © 2019 Acharya et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Munjal M. Acharya1,*,
  2. Janet E. Baulch1,*,
  3. Peter M. Klein2,*,
  4. Al Anoud D. Baddour1,
  5. Lauren A. Apodaca1,
  6. Eniko A. Kramár3,
  7. Leila Alikhani1,
  8. Camillo Garcia Jr1,
  9. Maria C. Angulo1,
  10. Raja S. Batra1,
  11. Christine M. Fallgren4,
  12. Thomas B. Borak4,
  13. Craig E. L. Stark3,
  14. Marcello A. Wood3,
  15. Richard A. Britten5,
  16. Ivan Soltesz2 and
  17. Charles L. Limoli1
  1. 1Department of Radiation Oncology, University of California, Irvine, California 92697
  2. 2Department of Neurosurgery, Stanford University, California 94305
  3. 3Department of Neurobiology and Behavior, University of California, Irvine, California 92697
  4. 4Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523
  5. 5Department of Radiation Oncology, Eastern Virginia Medical School, Norfolk, Virginia 23507
  1. Correspondence should be addressed to Charles L. Limoli at Climoli{at}uci.edu.
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Author contributions

  1. Author contributions: M.M.A., J.E.B., I.S., and C.L.L. designed research; M.M.A., J.E.B., P.M.K., A.A.D.B., L.A.A., E.A.K., L.A., C.G., M.C.A., R.S.B., and C.M.F. performed research; M.M.A., J.E.B., P.M.K., T.B.B., and C.L.L. contributed unpublished reagents/analytic tools; M.M.A., J.E.B., P.M.K., E.A.K., R.A.B., and I.S. analyzed data; M.M.A., J.E.B., P.M.K., C.E.L.S., M.A.W., R.A.B., I.S., and C.L.L. wrote the paper.

  2. ↵* M.M.A., J.E.B., and P.M.K. contributed equally to this work.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by UCI Institute for Clinical and Translational Sciences (ICTS) KL2 training award KL2TR001416 (M.M.A.), NASA Specialized Center of Research (NSCOR) grant NNX15AK13G for funding the neutron irradiator, and NSCOR grant NNX15AI22G (R.A.B., I.S., C.L.L.).

Funding

  • NASA | Johnson Space Center (JSC)

    NNX15AI22G

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  • You are viewing the most recent version of this article.
  • previous version (August 05, 2019).

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AbstractFullPdf
Aug 201969579521699
Oct 201952896116
Nov 201937656131
Dec 20193247871
Total 2019707829822017
Jan 20202246544
Feb 20201638470
Mar 2020922435
May 2020723051
Jun 2020331235
Jul 2020332241
Aug 2020514235
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Total 20201003152480
Jan 2021224522
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Apr 2021519347
May 2021321731
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Aug 2021118333
Sep 2021624950
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Total 2021442295479
Jan 2022116220
Feb 2022314025
Mar 2022416335
Apr 2022611627
May 2022319041
Jun 2022210015
Jul 202229811
Aug 202269919
Sep 202238626
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Total 2022461448291
Jan 2023511133
Feb 202378721
Mar 20233211130
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May 2023128220
Jun 2023149417
Jul 20231310030
Aug 20231211742
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Total 20231961540323
Jan 2024259273
Feb 20242813660
Mar 20241011930
Apr 2024339742
May 20241811023
Jun 20241010221
Jul 20241011019
Aug 2024139421
Sep 20241911920
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Total 20242091395414
Jan 20251116733
Feb 20251526213
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Apr 20251514728
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Jun 20253216628
Jul 20251812545
Aug 20252112739
Sep 20251829135
Oct 20254228737
Nov 20253427035
Dec 20251423840
Total 20252542530485
Jan 20261915925
Total 20261915925
Total7946155014514
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New Concerns for Neurocognitive Function during Deep Space Exposures to Chronic, Low Dose-Rate, Neutron Radiation
Munjal M. Acharya, Janet E. Baulch, Peter M. Klein, Al Anoud D. Baddour, Lauren A. Apodaca, Eniko A. Kramár, Leila Alikhani, Camillo Garcia Jr, Maria C. Angulo, Raja S. Batra, Christine M. Fallgren, Thomas B. Borak, Craig E. L. Stark, Marcello A. Wood, Richard A. Britten, Ivan Soltesz, Charles L. Limoli
eNeuro 5 August 2019, 6 (4) ENEURO.0094-19.2019; DOI: 10.1523/ENEURO.0094-19.2019

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New Concerns for Neurocognitive Function during Deep Space Exposures to Chronic, Low Dose-Rate, Neutron Radiation
Munjal M. Acharya, Janet E. Baulch, Peter M. Klein, Al Anoud D. Baddour, Lauren A. Apodaca, Eniko A. Kramár, Leila Alikhani, Camillo Garcia Jr, Maria C. Angulo, Raja S. Batra, Christine M. Fallgren, Thomas B. Borak, Craig E. L. Stark, Marcello A. Wood, Richard A. Britten, Ivan Soltesz, Charles L. Limoli
eNeuro 5 August 2019, 6 (4) ENEURO.0094-19.2019; DOI: 10.1523/ENEURO.0094-19.2019
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Keywords

  • cognitive dysfunction
  • electrophysiology
  • long-term potentiation
  • low dose-rate
  • neutrons
  • space radiation

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