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Research ArticleNew Research, Cognition and Behavior

GPR88 in D1R-Type and D2R-Type Medium Spiny Neurons Differentially Regulates Affective and Motor Behavior

A. C. Meirsman, Sami Ben Hamida, E. Clarke, A. de Kerchove d’Exaerde, E. Darcq and B. L. Kieffer
eNeuro 25 July 2019, 6 (4) ENEURO.0035-19.2019; https://doi.org/10.1523/ENEURO.0035-19.2019
A. C. Meirsman
1Département de Médecine Translationnelle et Neurogénétique, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Institut National de la Santé et de la Recherche Médicale Unité 964, Centre National de la Recherche Scientifique Unité Mixte de Recherche 7104, Université de Strasbourg, Illkirch, France
2Neuroscience Paris Seine, Institut de Biologie Paris Seine, Centre National de la Recherche Scientifique Unité Mixte de Recherche 8246/Institut National de la Santé et de la Recherche Médicale Unité 1130/Université Pierre et Marie Currie, Paris F-75005, France
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Sami Ben Hamida
3Douglas Research Center, Department of Psychiatry, McGill University, Montréal, Canada
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E. Clarke
3Douglas Research Center, Department of Psychiatry, McGill University, Montréal, Canada
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A. de Kerchove d’Exaerde
4Laboratory of Neurophysiology, Université Libre de Bruxelles (ULB), ULB Neuroscience Institute, 1070 Brussels, Belgium
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  • ORCID record for A. de Kerchove d’Exaerde
E. Darcq
3Douglas Research Center, Department of Psychiatry, McGill University, Montréal, Canada
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B. L. Kieffer
3Douglas Research Center, Department of Psychiatry, McGill University, Montréal, Canada
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0035-19.2019
PubMed 
31346000
Published By 
Society for Neuroscience
History 
  • Received January 24, 2019
  • Revision received May 13, 2019
  • Accepted May 19, 2019
  • Published online July 25, 2019.
Copyright & Usage 
Copyright © 2019 Meirsman et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. A. C. Meirsman1,2,
  2. Sami Ben Hamida3,
  3. E. Clarke3,
  4. A. de Kerchove d’Exaerde4,
  5. E. Darcq3 and
  6. B. L. Kieffer3
  1. 1Département de Médecine Translationnelle et Neurogénétique, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Institut National de la Santé et de la Recherche Médicale Unité 964, Centre National de la Recherche Scientifique Unité Mixte de Recherche 7104, Université de Strasbourg, Illkirch, France
  2. 2Neuroscience Paris Seine, Institut de Biologie Paris Seine, Centre National de la Recherche Scientifique Unité Mixte de Recherche 8246/Institut National de la Santé et de la Recherche Médicale Unité 1130/Université Pierre et Marie Currie, Paris F-75005, France
  3. 3Douglas Research Center, Department of Psychiatry, McGill University, Montréal, Canada
  4. 4Laboratory of Neurophysiology, Université Libre de Bruxelles (ULB), ULB Neuroscience Institute, 1070 Brussels, Belgium
  1. Correspondence should be addressed to B.L. Kieffer at brigitte.kieffer{at}douglas.mcgill.ca
View Full Text

Author contributions

  1. Author contributions: A.C.M., S.B.H., and B.L.K. designed research; A.C.M., S.B.H., E.C., and E.D. performed research; A.C.M., S.B.H., E.D., and B.L.K. analyzed data; A.C.M., S.B.H., A.d.K.d., E.D., and B.L.K. wrote the paper.

Disclosures

  • All authors declare no competing financial interests.

  • This work was supported by the National Institutes of Health National Institute of Drug Abuse Grant 05010 (to B.L.K.), the National Institute on Alcohol Abuse and Alcoholism Grant 16658 (to B.L.K.), the Canada Fund for Innovation and the Canada Research Chairs (B.L.K.), Fonds de la Recherche Scientifique - FNRS (Belgium; A.K.E.), and Fondation Simone et Pierre Clerdent (Belgium; A.K.E.). A.C.M. was supported by a doctoral fellowship from Fondation Française pour la Recherche Médicale (FRM: FDT20140930830). A.K.E. is a Research Director of the FRS–FNRS (Belgium) and a WELBIO investigator (Belgium). This work was also supported by the ATHOS Consortium, including the Fonds Unique Interministériel (FUI), the Région Alsace and our partners, Domain Therapeutics (Illkirch, France), and Prestwick Chemicals (Illkirch, France).

Funding

  • HHS | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA)

    16658
  • HHS | NIH | National Institute on Drug Abuse (NIDA)

    05010
  • Canada Foundation for Innovation (CFI)

  • Canada Research Chairs (Chaires de recherche du Canada)

  • Fondation pour la Recherche Médicale (FRM)

    FDT20140930830
  • FRS-FNRS

Other Version

  • You are viewing the most recent version of this article.
  • previous version (July 25, 2019).

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Jul 20191840102
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Feb 20262011623
Mar 202613412
Total 20264527379
Total91867181645
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GPR88 in D1R-Type and D2R-Type Medium Spiny Neurons Differentially Regulates Affective and Motor Behavior
A. C. Meirsman, Sami Ben Hamida, E. Clarke, A. de Kerchove d’Exaerde, E. Darcq, B. L. Kieffer
eNeuro 25 July 2019, 6 (4) ENEURO.0035-19.2019; DOI: 10.1523/ENEURO.0035-19.2019

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GPR88 in D1R-Type and D2R-Type Medium Spiny Neurons Differentially Regulates Affective and Motor Behavior
A. C. Meirsman, Sami Ben Hamida, E. Clarke, A. de Kerchove d’Exaerde, E. Darcq, B. L. Kieffer
eNeuro 25 July 2019, 6 (4) ENEURO.0035-19.2019; DOI: 10.1523/ENEURO.0035-19.2019
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Keywords

  • anxiety
  • locomotion
  • medium spiny neuron
  • motor coordination
  • orphan GPCR
  • striatum

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