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Research ArticleNew Research, Cognition and Behavior

The Basolateral Nucleus of the Amygdala Executes the Parallel Processes of Avoidance and Palatability in the Retrieval of Conditioned Taste Aversion in Male Rats

Tadashi Inui, Tomoaki Sugishita, Chizuko Inui-Yamamoto, Yasunobu Yasoshima and Tsuyoshi Shimura
eNeuro 24 June 2019, 6 (4) ENEURO.0004-19.2019; https://doi.org/10.1523/ENEURO.0004-19.2019
Tadashi Inui
1Division of Behavioral Physiology, Department of Behavioral Sciences, Graduate School of Human Sciences, Osaka University, Osaka 565-0871, Japan
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Tomoaki Sugishita
1Division of Behavioral Physiology, Department of Behavioral Sciences, Graduate School of Human Sciences, Osaka University, Osaka 565-0871, Japan
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Chizuko Inui-Yamamoto
2Department of Oral Anatomy and Developmental Biology, Osaka University Graduate School of Dentistry, Osaka 565-0871, Japan
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Yasunobu Yasoshima
1Division of Behavioral Physiology, Department of Behavioral Sciences, Graduate School of Human Sciences, Osaka University, Osaka 565-0871, Japan
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Tsuyoshi Shimura
1Division of Behavioral Physiology, Department of Behavioral Sciences, Graduate School of Human Sciences, Osaka University, Osaka 565-0871, Japan
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Abstract

Conditioned taste aversion (CTA) is an essential behavior for animal survival. Conditioned animals show avoidance and decreased palatability to a conditioned stimulus (CS) on CTA retrieval. In this study, we aimed to determine whether the basolateral nucleus of the amygdala (BLA) is involved in CTA retrieval and whether avoidance and palatability in CTA retrieval are processed in the BLA. We developed an experimental chamber for time-course analysis of the behavior to approach a spout and lick a CS. In this experimental chamber, we analyzed the behavior of male rats following microinjections of GABAA receptor agonist muscimol or saline into the BLA. The rats showed two types of approach behavior: they either (1) approached and licked the spout or (2) approached but did not lick the spout. Muscimol injection into the BLA decreased the frequency of the latter type of approach behavior, indicating that BLA inactivation reduced avoidance to the CS. The muscimol injection into the BLA also significantly increased the consumption of the CS. Lick microstructure analysis demonstrated that intra-BLA muscimol significantly increased licking burst number and size, indicating that BLA inactivation attenuated aversion to the CS as large burst licking is an indicator of high palatability. These results suggest that the increase in CS consumption with intra-BLA muscimol injection was due to alterations in approach and aversive responses to the CS. Therefore, we conclude that the BLA plays an essential role in CTA retrieval by parallel processing of avoidance and palatability.

  • avoidance
  • conditioned taste aversion
  • new method of behavioral experiment
  • palatability
  • retrieval
  • the basolateral nucleus of the amygdala

Footnotes

  • The authors declare no competing financial interests.

  • This work was supported in part by the Japan Society for the Promotion of Science (JSPS) Grant 24500973 (to T.I.).

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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The Basolateral Nucleus of the Amygdala Executes the Parallel Processes of Avoidance and Palatability in the Retrieval of Conditioned Taste Aversion in Male Rats
Tadashi Inui, Tomoaki Sugishita, Chizuko Inui-Yamamoto, Yasunobu Yasoshima, Tsuyoshi Shimura
eNeuro 24 June 2019, 6 (4) ENEURO.0004-19.2019; DOI: 10.1523/ENEURO.0004-19.2019

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The Basolateral Nucleus of the Amygdala Executes the Parallel Processes of Avoidance and Palatability in the Retrieval of Conditioned Taste Aversion in Male Rats
Tadashi Inui, Tomoaki Sugishita, Chizuko Inui-Yamamoto, Yasunobu Yasoshima, Tsuyoshi Shimura
eNeuro 24 June 2019, 6 (4) ENEURO.0004-19.2019; DOI: 10.1523/ENEURO.0004-19.2019
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Keywords

  • avoidance
  • conditioned taste aversion
  • new method of behavioral experiment
  • palatability
  • retrieval
  • the basolateral nucleus of the amygdala

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