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Research ArticleNew Research, Neuronal Excitability

Cerebellar Stellate Cell Excitability Is Coordinated by Shifts in the Gating Behavior of Voltage-Gated Na+ and A-Type K+ Channels

Ryan P.D. Alexander, John Mitry, Vasu Sareen, Anmar Khadra and Derek Bowie
eNeuro 20 May 2019, 6 (3) ENEURO.0126-19.2019; DOI: https://doi.org/10.1523/ENEURO.0126-19.2019
Ryan P.D. Alexander
1Integrated Program in Neuroscience, McGill University, Montréal, Quebec H3A 2B4, Canada
2Department of Pharmacology and Therapeutics, McGill University, Montréal, Quebec H3G 1Y6, Canada
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John Mitry
3Department of Physiology, McGill University, Montréal, Quebec H3G 1Y6, Canada
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Vasu Sareen
3Department of Physiology, McGill University, Montréal, Quebec H3G 1Y6, Canada
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Anmar Khadra
3Department of Physiology, McGill University, Montréal, Quebec H3G 1Y6, Canada
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Derek Bowie
2Department of Pharmacology and Therapeutics, McGill University, Montréal, Quebec H3G 1Y6, Canada
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0126-19.2019
PubMed 
31110133
Published By 
Society for Neuroscience
History 
  • Received April 1, 2019
  • Revision received April 26, 2019
  • Accepted May 13, 2019
  • Published online May 20, 2019.
Copyright & Usage 
Copyright © 2019 Alexander et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Ryan P.D. Alexander1,2,
  2. John Mitry3,
  3. Vasu Sareen3,
  4. Anmar Khadra3 and
  5. Derek Bowie2
  1. 1Integrated Program in Neuroscience, McGill University, Montréal, Quebec H3A 2B4, Canada
  2. 2Department of Pharmacology and Therapeutics, McGill University, Montréal, Quebec H3G 1Y6, Canada
  3. 3Department of Physiology, McGill University, Montréal, Quebec H3G 1Y6, Canada
  1. Correspondence should be addressed to Derek Bowie at derek.bowie{at}mcgill.ca.
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Author contributions

  1. Author contributions: R.P.D.A., J.M., A.K., and D.B. designed research; R.P.D.A., J.M., and V.S. performed research; R.P.D.A., J.M., and V.S. analyzed data; R.P.D.A., A.K., and D.B. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the Canadian Institutes of Health Research Operating Grant MOP 142431 (to D.B.) and by a National Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery Grant (A.K.). R.P.D.A. was supported by a NSERC CGS-D Doctoral Fellowship.

Funding

  • Gouvernement du Canada | Canadian Institutes of Health Research (CIHR)

    MOP 142431
  • Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (NSERC)

Other Version

  • previous version (May 20, 2019).
  • You are viewing the most recent version of this article.

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Cerebellar Stellate Cell Excitability Is Coordinated by Shifts in the Gating Behavior of Voltage-Gated Na+ and A-Type K+ Channels
Ryan P.D. Alexander, John Mitry, Vasu Sareen, Anmar Khadra, Derek Bowie
eNeuro 20 May 2019, 6 (3) ENEURO.0126-19.2019; DOI: 10.1523/ENEURO.0126-19.2019

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Cerebellar Stellate Cell Excitability Is Coordinated by Shifts in the Gating Behavior of Voltage-Gated Na+ and A-Type K+ Channels
Ryan P.D. Alexander, John Mitry, Vasu Sareen, Anmar Khadra, Derek Bowie
eNeuro 20 May 2019, 6 (3) ENEURO.0126-19.2019; DOI: 10.1523/ENEURO.0126-19.2019
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Keywords

  • A-type potassium channel
  • action potential
  • cerebellum
  • computational modeling
  • sodium channel
  • stellate cell

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