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Research ArticleNew Research, Cognition and Behavior

The NeuroD6 Subtype of VTA Neurons Contributes to Psychostimulant Sensitization and Behavioral Reinforcement

Zisis Bimpisidis, Niclas König, Stefanos Stagkourakis, Vivien Zell, Bianca Vlcek, Sylvie Dumas, Bruno Giros, Christian Broberger, Thomas S. Hnasko and Åsa Wallén-Mackenzie
eNeuro 16 May 2019, 6 (3) ENEURO.0066-19.2019; https://doi.org/10.1523/ENEURO.0066-19.2019
Zisis Bimpisidis
1Department of Organismal Biology, Uppsala University, 75236 Uppsala, Sweden
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  • ORCID record for Zisis Bimpisidis
Niclas König
1Department of Organismal Biology, Uppsala University, 75236 Uppsala, Sweden
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Stefanos Stagkourakis
2Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
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Vivien Zell
3Department of Neurosciences, University of California, San Diego, La Jolla, CA
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Bianca Vlcek
1Department of Organismal Biology, Uppsala University, 75236 Uppsala, Sweden
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  • ORCID record for Bianca Vlcek
Sylvie Dumas
5Oramacell, 8 Rue Grégoire de Tours, 75006 Paris, France
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Bruno Giros
6Institut National de la Santé et de la Recherche Médicale, INSERM UMRS 1130; Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8246; Sorbonne University Université Pierre-et-Marie-Curie, Neurosciences Paris-Seine, F-75005, Paris, France
7Douglas Mental Health University Institute 6875 LaSalle blvd, Verdun (Qc), H4H 1R3, Montreal, Canada
8Department of Psychiatry, McGill University, Montreal, Canada
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Christian Broberger
2Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
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Thomas S. Hnasko
3Department of Neurosciences, University of California, San Diego, La Jolla, CA
4Research Service VA San Diego Healthcare System, San Diego, CA 92161
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Åsa Wallén-Mackenzie
1Department of Organismal Biology, Uppsala University, 75236 Uppsala, Sweden
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0066-19.2019
PubMed 
31097625
Published By 
Society for Neuroscience
History 
  • Received February 22, 2019
  • Revision received May 7, 2019
  • Accepted May 9, 2019
  • Published online May 16, 2019.
Copyright & Usage 
Copyright © 2019 Bimpisidis et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Zisis Bimpisidis1,
  2. Niclas König1,
  3. Stefanos Stagkourakis2,
  4. Vivien Zell3,
  5. Bianca Vlcek1,
  6. Sylvie Dumas5,
  7. Bruno Giros6,7,8,
  8. Christian Broberger2,
  9. Thomas S. Hnasko3,4 and
  10. Åsa Wallén-Mackenzie1
  1. 1Department of Organismal Biology, Uppsala University, 75236 Uppsala, Sweden
  2. 2Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
  3. 3Department of Neurosciences, University of California, San Diego, La Jolla, CA
  4. 4Research Service VA San Diego Healthcare System, San Diego, CA 92161
  5. 5Oramacell, 8 Rue Grégoire de Tours, 75006 Paris, France
  6. 6Institut National de la Santé et de la Recherche Médicale, INSERM UMRS 1130; Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8246; Sorbonne University Université Pierre-et-Marie-Curie, Neurosciences Paris-Seine, F-75005, Paris, France
  7. 7Douglas Mental Health University Institute 6875 LaSalle blvd, Verdun (Qc), H4H 1R3, Montreal, Canada
  8. 8Department of Psychiatry, McGill University, Montreal, Canada
  1. Correspondence should be addressed to Åsa Wallén-Mackenzie at asa.mackenzie{at}ebc.uu.se
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Author contributions

  1. Author contributions: Å.W.M conceived the study and was in charge of overall direction and planning; Z.B., S.S., V.Z., S.D., C.B., T.S.H., and Å.W.-M. designed research; Z.B., N.K., S.S., V.Z., B.V., S.D., and Å.W.-M. performed research; Z.B., N.K., S.S., V.Z., B.V., S.D., C.B., T.S.H., and Å.W.-M. analyzed data; Z.B. and Å.W.-M. wrote the paper; B.G. contributed transgenic tool.

Disclosures

  • S.D. is the owner of Oramacell. All other authors declare no competing financial interests.

  • Work in Å.W.-M. lab was supported by Uppsala University, Vetenskapsrådet (Medicine & Health), Hjärnfonden, Parkinsonfonden, and the Research Foundations of Bertil Hållsten, OE & Edla Johansson, Zoologisk Forskning, and Åhlén. Work in C.B. lab was supported by Vetenskapsrådet (Medicine & Health), the European Research Council, Novo Nordisk Fonden, and the Strategic Research Programme for Diabetes Research at Karolinska Institutet. Work in T.S.H. lab was supported by the National Institutes of Health Grant DA036612 and the Veterans Affairs Grant BX003759.

Funding

  • hjärnfonden

  • vetenskapsrådet

Other Version

  • You are viewing the most recent version of this article.
  • previous version (May 16, 2019).

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May 20195110161
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Total 2025881424291
Total138266502191
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The NeuroD6 Subtype of VTA Neurons Contributes to Psychostimulant Sensitization and Behavioral Reinforcement
Zisis Bimpisidis, Niclas König, Stefanos Stagkourakis, Vivien Zell, Bianca Vlcek, Sylvie Dumas, Bruno Giros, Christian Broberger, Thomas S. Hnasko, Åsa Wallén-Mackenzie
eNeuro 16 May 2019, 6 (3) ENEURO.0066-19.2019; DOI: 10.1523/ENEURO.0066-19.2019

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The NeuroD6 Subtype of VTA Neurons Contributes to Psychostimulant Sensitization and Behavioral Reinforcement
Zisis Bimpisidis, Niclas König, Stefanos Stagkourakis, Vivien Zell, Bianca Vlcek, Sylvie Dumas, Bruno Giros, Christian Broberger, Thomas S. Hnasko, Åsa Wallén-Mackenzie
eNeuro 16 May 2019, 6 (3) ENEURO.0066-19.2019; DOI: 10.1523/ENEURO.0066-19.2019
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Keywords

  • Accumbens
  • dopamine
  • mouse genetics
  • optogenetics
  • reward
  • ventral tegmental area

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