Skip to main content

Umbrella menu

  • SfN.org
  • eNeuro
  • The Journal of Neuroscience
  • Neuronline
  • BrainFacts.org

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Latest Articles
    • Issue Archive
    • Editorials
    • Research Highlights
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • EDITORIAL BOARD
  • BLOG
  • ABOUT
    • Overview
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
  • SfN.org
  • eNeuro
  • The Journal of Neuroscience
  • Neuronline
  • BrainFacts.org

User menu

  • My alerts

Search

  • Advanced search
eNeuro
  • My alerts

eNeuro

Advanced Search

Submit a Manuscript
  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Latest Articles
    • Issue Archive
    • Editorials
    • Research Highlights
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • EDITORIAL BOARD
  • BLOG
  • ABOUT
    • Overview
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
PreviousNext
Research ArticleNew Research, Sensory and Motor Systems

Synaptic Basis for Contrast-Dependent Shifts in Functional Identity in Mouse V1

Molis Yunzab, Veronica Choi, Hamish Meffin, Shaun L. Cloherty, Nicholas J. Priebe and Michael R. Ibbotson
eNeuro 20 March 2019, 6 (2) ENEURO.0480-18.2019; DOI: https://doi.org/10.1523/ENEURO.0480-18.2019
Molis Yunzab
1National Vision Research Institute, Australian College of Optometry, Carlton, Victoria 3053, Australia
2Department of Optometry and Vision Sciences, University of Melbourne, Parkville, Victoria 3010, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Molis Yunzab
Veronica Choi
3 University of Texas Austin, Centre for Learning and Memory, Austin, TX 78712
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Veronica Choi
Hamish Meffin
1National Vision Research Institute, Australian College of Optometry, Carlton, Victoria 3053, Australia
2Department of Optometry and Vision Sciences, University of Melbourne, Parkville, Victoria 3010, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Hamish Meffin
Shaun L. Cloherty
1National Vision Research Institute, Australian College of Optometry, Carlton, Victoria 3053, Australia
2Department of Optometry and Vision Sciences, University of Melbourne, Parkville, Victoria 3010, Australia
4Department of Physiology, Monash University, Clayton, Victoria 3800, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Shaun L. Cloherty
Nicholas J. Priebe
3 University of Texas Austin, Centre for Learning and Memory, Austin, TX 78712
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michael R. Ibbotson
1National Vision Research Institute, Australian College of Optometry, Carlton, Victoria 3053, Australia
2Department of Optometry and Vision Sciences, University of Melbourne, Parkville, Victoria 3010, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

A central transformation that occurs within mammalian visual cortex is the change from linear, polarity-sensitive responses to nonlinear, polarity-insensitive responses. These neurons are classically labelled as either simple or complex, respectively, on the basis of their response linearity (Skottun et al., 1991). While the difference between cell classes is clear when the stimulus strength is high, reducing stimulus strength diminishes the differences between the cell types and causes some complex cells to respond as simple cells (Crowder et al., 2007; van Kleef et al., 2010; Hietanen et al., 2013). To understand the synaptic basis for this shift in behavior, we used in vivo whole-cell recordings while systematically shifting stimulus contrast. We find systematic shifts in the degree of complex cell responses in mouse primary visual cortex (V1) at the subthreshold level, demonstrating that synaptic inputs change in concert with the shifts in response linearity and that the change in response linearity is not simply due to the threshold nonlinearity. These shifts are consistent with a visual cortex model in which the recurrent amplification acts as a critical component in the generation of complex cell responses (Chance et al., 1999).

  • complex cell
  • in vivo whole-cell recording
  • phase sensitivity
  • primary visual cortex
  • visual system

Footnotes

  • The authors declare no competing financial interests.

  • This work was supported by the Australian Research Council Centre of Excellence for Integrative Brain Function Grant CE140100007, the National Health and Medical Research Council Grant GNT0525459, the National Health Institutes Grant EY 020592 and the L.E.W. Carty Charitable Fund & Lions Foundation of Victoria.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

View Full Text
Back to top

In this issue

eneuro: 6 (2)
eNeuro
Vol. 6, Issue 2
March/April 2019
  • Table of Contents
  • Index by author
Email

Thank you for sharing this eNeuro article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Synaptic Basis for Contrast-Dependent Shifts in Functional Identity in Mouse V1
(Your Name) has forwarded a page to you from eNeuro
(Your Name) thought you would be interested in this article in eNeuro.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Citation Tools
Synaptic Basis for Contrast-Dependent Shifts in Functional Identity in Mouse V1
Molis Yunzab, Veronica Choi, Hamish Meffin, Shaun L. Cloherty, Nicholas J. Priebe, Michael R. Ibbotson
eNeuro 20 March 2019, 6 (2) ENEURO.0480-18.2019; DOI: 10.1523/ENEURO.0480-18.2019

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Share
Synaptic Basis for Contrast-Dependent Shifts in Functional Identity in Mouse V1
Molis Yunzab, Veronica Choi, Hamish Meffin, Shaun L. Cloherty, Nicholas J. Priebe, Michael R. Ibbotson
eNeuro 20 March 2019, 6 (2) ENEURO.0480-18.2019; DOI: 10.1523/ENEURO.0480-18.2019
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Significance Statement
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Footnotes
    • References
    • Synthesis
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • complex cell
  • in vivo whole-cell recording
  • phase sensitivity
  • primary visual cortex
  • visual system

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

New Research

  • Altered phosphorylation of the proteasome subunit Rpt6 has minimal impact on synaptic plasticity and learning
  • Social Experience Interacts with Serotonin to Affect Functional Connectivity in the Social Behavior Network following Playback of Social Vocalizations in Mice
  • Effects of optogenetic suppression of cortical input on primate thalamic neuronal activity during goal-directed behavior
Show more New Research

Sensory and Motor Systems

  • Effects of optogenetic suppression of cortical input on primate thalamic neuronal activity during goal-directed behavior
  • A role for STOML3 in olfactory sensory transduction
  • Otoacoustic emissions evoked by the time-varying harmonic structure of speech
Show more Sensory and Motor Systems

Subjects

  • Sensory and Motor Systems
  • Home
  • Alerts
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Latest Articles
  • Issue Archive
  • Blog
  • Browse by Topic

Information

  • For Authors
  • For the Media

About

  • About the Journal
  • Editorial Board
  • Privacy Policy
  • Contact
  • Feedback
(eNeuro logo)
(SfN logo)

Copyright © 2021 by the Society for Neuroscience.
eNeuro eISSN: 2373-2822

The ideas and opinions expressed in eNeuro do not necessarily reflect those of SfN or the eNeuro Editorial Board. Publication of an advertisement or other product mention in eNeuro should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in eNeuro.