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Research ArticleNew Research, Cognition and Behavior

The Rat Medial Prefrontal Cortex Exhibits Flexible Neural Activity States during the Performance of an Odor Span Task

Emanuela De Falco, Lei An, Ninglei Sun, Andrew J. Roebuck, Quentin Greba, Christopher C. Lapish and John G. Howland
eNeuro 4 March 2019, 6 (2) ENEURO.0424-18.2019; https://doi.org/10.1523/ENEURO.0424-18.2019
Emanuela De Falco
1Department of Psychology, Indiana University-Purdue University Indianapolis, Indiana 46202
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Lei An
2Department of Anatomy, Physiology, and Pharmacology, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E5, Canada
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Ninglei Sun
2Department of Anatomy, Physiology, and Pharmacology, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E5, Canada
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Andrew J. Roebuck
2Department of Anatomy, Physiology, and Pharmacology, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E5, Canada
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Quentin Greba
2Department of Anatomy, Physiology, and Pharmacology, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E5, Canada
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Christopher C. Lapish
1Department of Psychology, Indiana University-Purdue University Indianapolis, Indiana 46202
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John G. Howland
2Department of Anatomy, Physiology, and Pharmacology, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E5, Canada
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0424-18.2019
PubMed 
31008186
Published By 
Society for Neuroscience
History 
  • Received October 30, 2018
  • Revision received February 13, 2019
  • Accepted February 18, 2019
  • Published online March 4, 2019.
Copyright & Usage 
Copyright © 2019 De Falco et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Emanuela De Falco1,*,
  2. Lei An2,*,
  3. Ninglei Sun2,
  4. Andrew J. Roebuck2,
  5. Quentin Greba2,
  6. Christopher C. Lapish1 and
  7. John G. Howland2
  1. 1Department of Psychology, Indiana University-Purdue University Indianapolis, Indiana 46202
  2. 2Department of Anatomy, Physiology, and Pharmacology, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E5, Canada
  1. Correspondence should be addressed to John G. Howland at john.howland{at}usask.ca or Christopher C. Lapish at lapishc{at}gmail.com.
  • L. An’s present address: Medical College of Acupuncture-Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, 510006 Guangzhou, China.

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Author contributions

  1. E.D.F., L.A., C.C.L., and J.G.H. designed research; E.D.F., L.A., N.S., A.J.R., C.C.L., and J.G.H. analyzed data; E.D.F., L.A., A.J.R., C.C.L., and J.G.H. wrote the paper; L.A., Q.G., and J.G.H. performed research.

  2. ↵* E.D.F. and L.A. contributed equally to this work.

  • L. An’s present address: Medical College of Acupuncture-Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, 510006 Guangzhou, China.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by a CIHR Open Operating Grant (125984) and NSERC Discovery Grant to J.G.H. and by the National Institutes of Health Grants AA022821, AA023786, and P60-AA007611 to C.C.L.; L.A. was supported by a Saskatchewan Health Research Foundation Fellowship, N.S. was supported by the College of Medicine (University of Saskatchewan), and A.J.R. was supported by an NSERC CREATE scholarship. We thank Jillian K. Catton and Alex Senger for technical assistance with this project, and Jeremy K. Seamans and James M. Hyman for comments on the paper.

Funding

  • Gouvernement du Canada | Canadian Institutes of Health Research (CIHR)

    125984
  • HHS | National Institutes of Health (NIH)

    AA022821

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  • You are viewing the most recent version of this article.
  • previous version (March 04, 2019).

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Total109648951589
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The Rat Medial Prefrontal Cortex Exhibits Flexible Neural Activity States during the Performance of an Odor Span Task
Emanuela De Falco, Lei An, Ninglei Sun, Andrew J. Roebuck, Quentin Greba, Christopher C. Lapish, John G. Howland
eNeuro 4 March 2019, 6 (2) ENEURO.0424-18.2019; DOI: 10.1523/ENEURO.0424-18.2019

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The Rat Medial Prefrontal Cortex Exhibits Flexible Neural Activity States during the Performance of an Odor Span Task
Emanuela De Falco, Lei An, Ninglei Sun, Andrew J. Roebuck, Quentin Greba, Christopher C. Lapish, John G. Howland
eNeuro 4 March 2019, 6 (2) ENEURO.0424-18.2019; DOI: 10.1523/ENEURO.0424-18.2019
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Keywords

  • electrophysiology
  • multivariate statistics
  • Odor
  • prefrontal cortex
  • pyramidal neuron
  • working memory

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