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Research ArticleNew Research, Disorders of the Nervous System

Restrained Dendritic Growth of Adult-Born Granule Cells Innervated by Transplanted Fetal GABAergic Interneurons in Mice with Temporal Lobe Epilepsy

Jyoti Gupta, Mark Bromwich, Jake E. Radell, Muhammad N. Arshad, Selena Gonzalez, Bryan W. Luikart, Gloster B. Aaron and Janice R. Naegele
eNeuro 27 March 2019, 6 (2) ENEURO.0110-18.2019; DOI: https://doi.org/10.1523/ENEURO.0110-18.2019
Jyoti Gupta
1Department of Biology, Program in Neuroscience and Behavior, Hall-Atwater Laboratory, Wesleyan University, Middletown, CT 06459-0170
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Mark Bromwich
1Department of Biology, Program in Neuroscience and Behavior, Hall-Atwater Laboratory, Wesleyan University, Middletown, CT 06459-0170
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Jake E. Radell
1Department of Biology, Program in Neuroscience and Behavior, Hall-Atwater Laboratory, Wesleyan University, Middletown, CT 06459-0170
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  • ORCID record for Jake E. Radell
Muhammad N. Arshad
1Department of Biology, Program in Neuroscience and Behavior, Hall-Atwater Laboratory, Wesleyan University, Middletown, CT 06459-0170
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Selena Gonzalez
1Department of Biology, Program in Neuroscience and Behavior, Hall-Atwater Laboratory, Wesleyan University, Middletown, CT 06459-0170
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Bryan W. Luikart
2Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03755-1404
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Gloster B. Aaron
1Department of Biology, Program in Neuroscience and Behavior, Hall-Atwater Laboratory, Wesleyan University, Middletown, CT 06459-0170
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Janice R. Naegele
1Department of Biology, Program in Neuroscience and Behavior, Hall-Atwater Laboratory, Wesleyan University, Middletown, CT 06459-0170
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0110-18.2019
PubMed 
31043461
Published By 
Society for Neuroscience
History 
  • Received March 19, 2018
  • Revision received March 11, 2019
  • Accepted March 15, 2019
  • Published online March 27, 2019.
Copyright & Usage 
Copyright © 2019 Gupta et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Jyoti Gupta1,
  2. Mark Bromwich1,
  3. Jake E. Radell1,
  4. Muhammad N. Arshad1,
  5. Selena Gonzalez1,
  6. Bryan W. Luikart2,
  7. Gloster B. Aaron1 and
  8. Janice R. Naegele1
  1. 1Department of Biology, Program in Neuroscience and Behavior, Hall-Atwater Laboratory, Wesleyan University, Middletown, CT 06459-0170
  2. 2Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03755-1404
  1. Correspondence should be addressed to Janice R. Naegele at jnaegele{at}wesleyan.edu.
View Full Text

Author contributions

  1. Author contributions: J.G. and J.R.N. designed research; J.G., M.B., J.E.R., M.N.A., S.G., and J.R.N. performed research; J.G. and J.R.N. analyzed data; J.G. and J.R.N. wrote the paper; B.W.L., G.B.A., and J.R.N. contributed unpublished reagents/analytic tools.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the National Institute of Neurological Disorders and Stroke Grant R15NS072879-01A1, a Connecticut Stem Cell Established Investigator grant, a Challenge Award from Citizens United for Research in Epilepsy (J.R.N.), and the National Institute of Mental Health Grant R01MH097949 (to B.L.).

Funding

  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    R15NS072879-01A1
  • HHS | NIH | National Institute of Mental Health (NIMH)

    R01MH097949
  • Citizens United for Research in Epilepsy (CURE)

    Challenge Award
  • Connecticut Regenerative Medicine Fund

    13-SCC-WES-01

Other Version

  • You are viewing the most recent version of this article.
  • previous version (March 27, 2019).

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Mar 2019105030
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May 201912441193
Jun 2019336914
Jul 2019429524
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Jul 202223815
Aug 20220379
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Total 2023513739
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Restrained Dendritic Growth of Adult-Born Granule Cells Innervated by Transplanted Fetal GABAergic Interneurons in Mice with Temporal Lobe Epilepsy
Jyoti Gupta, Mark Bromwich, Jake E. Radell, Muhammad N. Arshad, Selena Gonzalez, Bryan W. Luikart, Gloster B. Aaron, Janice R. Naegele
eNeuro 27 March 2019, 6 (2) ENEURO.0110-18.2019; DOI: 10.1523/ENEURO.0110-18.2019

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Restrained Dendritic Growth of Adult-Born Granule Cells Innervated by Transplanted Fetal GABAergic Interneurons in Mice with Temporal Lobe Epilepsy
Jyoti Gupta, Mark Bromwich, Jake E. Radell, Muhammad N. Arshad, Selena Gonzalez, Bryan W. Luikart, Gloster B. Aaron, Janice R. Naegele
eNeuro 27 March 2019, 6 (2) ENEURO.0110-18.2019; DOI: 10.1523/ENEURO.0110-18.2019
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Keywords

  • dendrite
  • dentate gyrus
  • GABAergic
  • hippocampus
  • neurogenesis
  • transplant

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