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Research ArticleNew Research, Disorders of the Nervous System

Electroconvulsive Shock Enhances Responsive Motility and Purinergic Currents in Microglia in the Mouse Hippocampus

Alberto Sepulveda-Rodriguez, Pinggan Li, Tahiyana Khan, James D. Ma, Colby A. Carlone, P. Lorenzo Bozzelli, Katherine E. Conant, Patrick A. Forcelli and Stefano Vicini
eNeuro 15 April 2019, 6 (2) ENEURO.0056-19.2019; https://doi.org/10.1523/ENEURO.0056-19.2019
Alberto Sepulveda-Rodriguez
1Department of Pharmacology and Physiology, Georgetown University, Washington, DC 20007
2Interdisciplinary Program in Neuroscience, Georgetown University, Washington, DC 20007
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  • ORCID record for Alberto Sepulveda-Rodriguez
Pinggan Li
1Department of Pharmacology and Physiology, Georgetown University, Washington, DC 20007
4Department of Pediatrics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China
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Tahiyana Khan
1Department of Pharmacology and Physiology, Georgetown University, Washington, DC 20007
2Interdisciplinary Program in Neuroscience, Georgetown University, Washington, DC 20007
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James D. Ma
1Department of Pharmacology and Physiology, Georgetown University, Washington, DC 20007
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Colby A. Carlone
1Department of Pharmacology and Physiology, Georgetown University, Washington, DC 20007
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P. Lorenzo Bozzelli
2Interdisciplinary Program in Neuroscience, Georgetown University, Washington, DC 20007
3Department of Neuroscience, Georgetown University, Washington, DC 20007
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Katherine E. Conant
2Interdisciplinary Program in Neuroscience, Georgetown University, Washington, DC 20007
3Department of Neuroscience, Georgetown University, Washington, DC 20007
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Patrick A. Forcelli
1Department of Pharmacology and Physiology, Georgetown University, Washington, DC 20007
2Interdisciplinary Program in Neuroscience, Georgetown University, Washington, DC 20007
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Stefano Vicini
1Department of Pharmacology and Physiology, Georgetown University, Washington, DC 20007
2Interdisciplinary Program in Neuroscience, Georgetown University, Washington, DC 20007
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0056-19.2019
PubMed 
31058213
Published By 
Society for Neuroscience
History 
  • Received February 13, 2019
  • Accepted April 9, 2019
  • Published online April 15, 2019.
Copyright & Usage 
Copyright © 2019 Sepulveda-Rodriguez et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Alberto Sepulveda-Rodriguez1,2,
  2. Pinggan Li1,4,
  3. Tahiyana Khan1,2,
  4. James D. Ma1,
  5. Colby A. Carlone1,
  6. P. Lorenzo Bozzelli2,3,
  7. Katherine E. Conant2,3,
  8. Patrick A. Forcelli1,2 and
  9. Stefano Vicini1,2
  1. 1Department of Pharmacology and Physiology, Georgetown University, Washington, DC 20007
  2. 2Interdisciplinary Program in Neuroscience, Georgetown University, Washington, DC 20007
  3. 3Department of Neuroscience, Georgetown University, Washington, DC 20007
  4. 4Department of Pediatrics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China
  1. Correspondence should be addressed to Stefano Vicini at svicin01{at}georgetown.edu
View Full Text

Author contributions

  1. Author contributions: A.S.-R., P.A.F., and S.V. designed research; A.S.-R., P.L., T.K., P.L.B., K.C., P.A.F., and S.V. performed research; A.S.-R., P.A.F., and S.V. contributed unpublished reagents/analytic tools; A.S.-R., P.L., T.K., J.D.M., C.A.C., P.L.B., K.C., P.A.F., and S.V. analyzed data; A.S.-R., T.K., P.A.F., and S.V. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by National Institutes of Health Grants KL2 TR001432 and R01 HD091994 (to P.A.F.) and T32 NS041218 (to P.L.B.) and the CONACyT (Mexican Council on Science and Technology) Fellowship 381291 (to A.S.-R.).

Funding

  • Consejo Nacional de Ciencia y Tecnología (CONACYT)

    381291
  • HHS | NIH | National Center for Advancing Translational Sciences (NCATS)

    KL2 TR001432
  • HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

    R01 HD091994
  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    T32 NS041218

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  • previous version (April 15, 2019).

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AbstractFullPdf
Apr 2019432186119
May 201949138998
Jun 20194639128
Jul 20194624738
Aug 20193010632
Oct 2019115827
Nov 2019144420
Dec 2019165011
Total 201910861471373
Jan 2020225721
Feb 2020123832
Mar 202084423
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Jul 2020511424
Aug 202064023
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Total 202087604263
Jan 202165916
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Jul 202135122
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Jan 202257327
Feb 202222914
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Jun 202215117
Jul 202213815
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Total 202226588224
Jan 202304217
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Total 202529365103
Total133354501638
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Electroconvulsive Shock Enhances Responsive Motility and Purinergic Currents in Microglia in the Mouse Hippocampus
Alberto Sepulveda-Rodriguez, Pinggan Li, Tahiyana Khan, James D. Ma, Colby A. Carlone, P. Lorenzo Bozzelli, Katherine E. Conant, Patrick A. Forcelli, Stefano Vicini
eNeuro 15 April 2019, 6 (2) ENEURO.0056-19.2019; DOI: 10.1523/ENEURO.0056-19.2019

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Electroconvulsive Shock Enhances Responsive Motility and Purinergic Currents in Microglia in the Mouse Hippocampus
Alberto Sepulveda-Rodriguez, Pinggan Li, Tahiyana Khan, James D. Ma, Colby A. Carlone, P. Lorenzo Bozzelli, Katherine E. Conant, Patrick A. Forcelli, Stefano Vicini
eNeuro 15 April 2019, 6 (2) ENEURO.0056-19.2019; DOI: 10.1523/ENEURO.0056-19.2019
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Keywords

  • ATP
  • ECT
  • epilepsy
  • neuroinflammation
  • patch-clamp electrophysiology
  • seizures

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