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Research ArticleNew Research, Disorders of the Nervous System

Nicotine Acts on Cholinergic Signaling Mechanisms to Directly Modulate Choroid Plexus Function

Valeria Lallai, Nickolas Grimes, James P. Fowler, P. Adolfo Sequeira, Preston Cartagena, Agenor Limon, Margaret Coutts, Edwin S. Monuki, William Bunney, Angelo Demuro and Christie D. Fowler
eNeuro 9 April 2019, 6 (2) ENEURO.0051-19.2019; https://doi.org/10.1523/ENEURO.0051-19.2019
Valeria Lallai
1Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA, 92697
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Nickolas Grimes
1Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA, 92697
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James P. Fowler
1Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA, 92697
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P. Adolfo Sequeira
2Department of Psychiatry and Human Behavior, School of Medicine, University of California Irvine, Irvine, CA 92697
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Preston Cartagena
2Department of Psychiatry and Human Behavior, School of Medicine, University of California Irvine, Irvine, CA 92697
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Agenor Limon
2Department of Psychiatry and Human Behavior, School of Medicine, University of California Irvine, Irvine, CA 92697
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Margaret Coutts
3Department of Pathology, School of Medicine, University of California Irvine, Irvine, CA, 92697
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Edwin S. Monuki
3Department of Pathology, School of Medicine, University of California Irvine, Irvine, CA, 92697
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  • ORCID record for Edwin S. Monuki
William Bunney
2Department of Psychiatry and Human Behavior, School of Medicine, University of California Irvine, Irvine, CA 92697
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Angelo Demuro
1Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA, 92697
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Christie D. Fowler
1Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA, 92697
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0051-19.2019
PubMed 
31119189
Published By 
Society for Neuroscience
History 
  • Received February 12, 2019
  • Revision received March 26, 2019
  • Accepted March 27, 2019
  • Published online April 9, 2019.
Copyright & Usage 
Copyright © 2019 Lallai et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Valeria Lallai1,
  2. Nickolas Grimes1,
  3. James P. Fowler1,
  4. P. Adolfo Sequeira2,
  5. Preston Cartagena2,
  6. Agenor Limon2,
  7. Margaret Coutts3,
  8. Edwin S. Monuki3,
  9. William Bunney2,
  10. Angelo Demuro1 and
  11. Christie D. Fowler1
  1. 1Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA, 92697
  2. 2Department of Psychiatry and Human Behavior, School of Medicine, University of California Irvine, Irvine, CA 92697
  3. 3Department of Pathology, School of Medicine, University of California Irvine, Irvine, CA, 92697
  1. Correspondence should be addressed to Christie D. Fowler at cdfowler{at}uci.edu
View Full Text

Author contributions

  1. Author contributions: V.L. and C.D.F. designed research; V.L., N.G., J.P.F., A.D., and C.D.F. performed research; V.L., N.G., A.D., and C.D.F. analyzed data; V.L., N.G., J.P.F., P.A.S., P.C., A.L., M.C., E.S.M., A.D., and C.D.F. wrote the paper; P.A.S., P.C., A.L., M.C., E.S.M., W.B., A.D., and C.D.F. contributed unpublished reagents/analytic tools.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the National Institutes of Health Grants DA032543 and DA039658 (to C.D.F.) and AG053988 (to A.D.).

Funding

  • HHS | NIH | National Institute on Drug Abuse (NIDA)

    DA032543; DA039658
  • HHS | NIH | National Institute on Aging (NIA)

    AG053988

Other Version

  • You are viewing the most recent version of this article.
  • previous version (April 09, 2019).

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Apr 201954412593
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Feb 2020117025
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Total 202574867259
Total133166271501
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Nicotine Acts on Cholinergic Signaling Mechanisms to Directly Modulate Choroid Plexus Function
Valeria Lallai, Nickolas Grimes, James P. Fowler, P. Adolfo Sequeira, Preston Cartagena, Agenor Limon, Margaret Coutts, Edwin S. Monuki, William Bunney, Angelo Demuro, Christie D. Fowler
eNeuro 9 April 2019, 6 (2) ENEURO.0051-19.2019; DOI: 10.1523/ENEURO.0051-19.2019

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Nicotine Acts on Cholinergic Signaling Mechanisms to Directly Modulate Choroid Plexus Function
Valeria Lallai, Nickolas Grimes, James P. Fowler, P. Adolfo Sequeira, Preston Cartagena, Agenor Limon, Margaret Coutts, Edwin S. Monuki, William Bunney, Angelo Demuro, Christie D. Fowler
eNeuro 9 April 2019, 6 (2) ENEURO.0051-19.2019; DOI: 10.1523/ENEURO.0051-19.2019
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Keywords

  • choroid plexus
  • drug dependence
  • microRNA
  • nicotine
  • nicotinic acetylcholine receptors
  • transthyretin

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