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Research ArticleNew Research, Disorders of the Nervous System

Epilepsy-Induced Reduction in HCN Channel Expression Contributes to an Increased Excitability in Dorsal, But Not Ventral, Hippocampal CA1 Neurons

Elizabeth C. Arnold, Calli McMurray, Richard Gray and Daniel Johnston
eNeuro 20 March 2019, 6 (2) ENEURO.0036-19.2019; https://doi.org/10.1523/ENEURO.0036-19.2019
Elizabeth C. Arnold
1Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712
2Center for Learning and Memory, University of Texas at Austin, Austin, TX 78712
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  • ORCID record for Elizabeth C. Arnold
Calli McMurray
2Center for Learning and Memory, University of Texas at Austin, Austin, TX 78712
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Richard Gray
2Center for Learning and Memory, University of Texas at Austin, Austin, TX 78712
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Daniel Johnston
1Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712
2Center for Learning and Memory, University of Texas at Austin, Austin, TX 78712
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0036-19.2019
PubMed 
30957013
Published By 
Society for Neuroscience
History 
  • Received January 27, 2019
  • Accepted March 5, 2019
  • Published online March 20, 2019.
Copyright & Usage 
Copyright © 2019 Arnold et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Elizabeth C. Arnold1,2,
  2. Calli McMurray2,
  3. Richard Gray2 and
  4. Daniel Johnston1,2
  1. 1Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712
  2. 2Center for Learning and Memory, University of Texas at Austin, Austin, TX 78712
  1. Correspondence should be addressed to Daniel Johnston at djohnston{at}mail.clm.utexas.edu.
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Author contributions

  1. Author contributions: E.C.A., R.G., and D.J. designed research; E.C.A., C.M., and R.G. performed research; E.C.A. and C.M. analyzed data; E.C.A., R.G., and D.J. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the Department of Health and Human Services National Institutes of Health Grant R01NS084473 (to D.J.) and the National Science Foundation Grant DGE-1610403 (to E.C.A.).

Funding

  • HHS | National Institutes of Health (NIH)

    R01NS084473
  • National Science Foundation (NSF)

    DGE-1610403

Other Version

  • You are viewing the most recent version of this article.
  • previous version (March 20, 2019).

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Total 202528459115
Total140147861584
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eneuro: 6 (2)
eNeuro
Vol. 6, Issue 2
March/April 2019
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Epilepsy-Induced Reduction in HCN Channel Expression Contributes to an Increased Excitability in Dorsal, But Not Ventral, Hippocampal CA1 Neurons
Elizabeth C. Arnold, Calli McMurray, Richard Gray, Daniel Johnston
eNeuro 20 March 2019, 6 (2) ENEURO.0036-19.2019; DOI: 10.1523/ENEURO.0036-19.2019

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Epilepsy-Induced Reduction in HCN Channel Expression Contributes to an Increased Excitability in Dorsal, But Not Ventral, Hippocampal CA1 Neurons
Elizabeth C. Arnold, Calli McMurray, Richard Gray, Daniel Johnston
eNeuro 20 March 2019, 6 (2) ENEURO.0036-19.2019; DOI: 10.1523/ENEURO.0036-19.2019
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Keywords

  • CA1 pyramidal neuron
  • dendrites
  • intrinsic properties
  • septotemporal axis
  • temporal lobe epilepsy
  • whole-cell electrophysiology

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