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Research ArticleConfirmation, Disorders of the Nervous System

Glucagon-Like Peptide-1 Cleavage Product Improves Cognitive Function in a Mouse Model of Down Syndrome

Stephen M. Day, Wenzhong Yang, Xin Wang, Jennifer E. Stern, Xueyan Zhou, Shannon L. Macauley and Tao Ma
eNeuro 30 April 2019, 6 (2) ENEURO.0031-19.2019; https://doi.org/10.1523/ENEURO.0031-19.2019
Stephen M. Day
1Departments of Internal Medicine and Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157
2Department of Integrative Physiology & Pharmacology, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157
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Wenzhong Yang
1Departments of Internal Medicine and Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157
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Xin Wang
1Departments of Internal Medicine and Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157
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Jennifer E. Stern
1Departments of Internal Medicine and Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157
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Xueyan Zhou
1Departments of Internal Medicine and Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157
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Shannon L. Macauley
1Departments of Internal Medicine and Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157
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Tao Ma
1Departments of Internal Medicine and Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157
2Department of Integrative Physiology & Pharmacology, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157
3Department of Neurobiology and Anatomy, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0031-19.2019
PubMed 
31040160
Published By 
Society for Neuroscience
History 
  • Received January 23, 2019
  • Revision received April 1, 2019
  • Accepted April 2, 2019
  • Published online April 30, 2019.
Copyright & Usage 
Copyright © 2019 Day et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Stephen M. Day1,2,
  2. Wenzhong Yang1,
  3. Xin Wang1,
  4. Jennifer E. Stern1,
  5. Xueyan Zhou1,
  6. Shannon L. Macauley1 and
  7. Tao Ma1,2,3
  1. 1Departments of Internal Medicine and Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157
  2. 2Department of Integrative Physiology & Pharmacology, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157
  3. 3Department of Neurobiology and Anatomy, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157
  1. Correspondence should be addressed to Tao Ma at Tma{at}wakehealth.edu.
View Full Text

Author contributions

  1. Author contributions: S.M.D. and T.M. designed research; S.M.D., W.Y., J.E.S., X.Z., and S.L.M. performed research; S.M.D., W.Y., X.W., J.E.S., S.L.M., and T.M. analyzed data; S.M.D. and T.M. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by National Institutes of Health Grants R01 AG055581, R01 AG056622 (T.M.), the Alzheimer’s Association grant NIRG-15-362799 (T.M.), and the BrightFocus Foundation Grant A2017457S.

Funding

  • NIH

    R01 AG055581; R01 AG056622
  • Alzheimer's Association

    NIRG-15-362799
  • BrightFocus Foundation

    A2017457S

Other Version

  • You are viewing the most recent version of this article.
  • previous version (April 30, 2019).

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AbstractFullPdf
Apr 201925010
May 20191106357166
Jun 201914318826
Jul 20195710516
Aug 2019318420
Oct 2019134212
Nov 2019194716
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Total 20191414868274
Jan 202014327
Feb 2020135827
Mar 202064313
May 202023617
Jun 202033113
Jul 202012814
Aug 20201182
Sep 202043215
Oct 202084120
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Total 202067468160
Jan 20212498
Feb 20214415
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Apr 202165514
May 202156219
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Jul 20213498
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Total 202134697171
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Apr 202224413
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Aug 202223110
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Total 202224485162
Jan 202323311
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Jun 2024126318
Jul 202436422
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Sep 2025109525
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Dec 2025199837
Total 2025144879321
Jan 20263711042
Feb 202631068
Total 20264021650
Total182154531520
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eneuro: 6 (2)
eNeuro
Vol. 6, Issue 2
March/April 2019
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Glucagon-Like Peptide-1 Cleavage Product Improves Cognitive Function in a Mouse Model of Down Syndrome
Stephen M. Day, Wenzhong Yang, Xin Wang, Jennifer E. Stern, Xueyan Zhou, Shannon L. Macauley, Tao Ma
eNeuro 30 April 2019, 6 (2) ENEURO.0031-19.2019; DOI: 10.1523/ENEURO.0031-19.2019

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Glucagon-Like Peptide-1 Cleavage Product Improves Cognitive Function in a Mouse Model of Down Syndrome
Stephen M. Day, Wenzhong Yang, Xin Wang, Jennifer E. Stern, Xueyan Zhou, Shannon L. Macauley, Tao Ma
eNeuro 30 April 2019, 6 (2) ENEURO.0031-19.2019; DOI: 10.1523/ENEURO.0031-19.2019
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Keywords

  • Alzheimer’s disease
  • Down syndrome
  • GLP-1 (9-36)
  • LTP
  • oxidative stress
  • synaptic plasticity

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