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Research ArticleMethods/New Tools, Novel Tools and Methods

An ATF3-CreERT2 Knock-In Mouse for Axotomy-Induced Genetic Editing: Proof of Principle

Seth D. Holland, Leanne M. Ramer, Stephen B. McMahon, Franziska Denk and Matt S. Ramer
eNeuro 28 March 2019, 6 (2) ENEURO.0025-19.2019; https://doi.org/10.1523/ENEURO.0025-19.2019
Seth D. Holland
1International Collaboration on Repair Discoveries, the University of British Columbia, Vancouver, British Columbia, Canada V5Z 1M9
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Leanne M. Ramer
2Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6
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Stephen B. McMahon
3Wolfson Centre for Age-Related Diseases, King’s College London, London, United Kingdom SE1 1UL
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  • ORCID record for Stephen B. McMahon
Franziska Denk
3Wolfson Centre for Age-Related Diseases, King’s College London, London, United Kingdom SE1 1UL
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Matt S. Ramer
1International Collaboration on Repair Discoveries, the University of British Columbia, Vancouver, British Columbia, Canada V5Z 1M9
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0025-19.2019
PubMed 
30993183
Published By 
Society for Neuroscience
History 
  • Received January 19, 2019
  • Revision received March 18, 2019
  • Accepted March 20, 2019
  • Published online March 28, 2019.
Copyright & Usage 
Copyright © 2019 Holland et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Seth D. Holland1,
  2. Leanne M. Ramer2,
  3. Stephen B. McMahon3,
  4. Franziska Denk3 and
  5. Matt S. Ramer1
  1. 1International Collaboration on Repair Discoveries, the University of British Columbia, Vancouver, British Columbia, Canada V5Z 1M9
  2. 2Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6
  3. 3Wolfson Centre for Age-Related Diseases, King’s College London, London, United Kingdom SE1 1UL
  1. Correspondence should be addressed to Matt S. Ramer at ramer{at}icord.org
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Author contributions

  1. Author contributions: S.D.H., S.B.M., F.D., and M.S.R. designed research; S.D.H., L.M.R., and M.S.R. performed research; S.D.H. and M.S.R. analyzed data; S.D.H., L.M.R., F.D., and M.S.R. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the International Foundation for Research in Paraplegia (M.S.R.) and the Wellcome Trust (F.D.).

Funding

  • International Foundation for Research in Paraplegia (IRP)

  • Wellcome Trust (Wellcome)

Other Version

  • You are viewing the most recent version of this article.
  • previous version (March 28, 2019).

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Mar 201970018
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eneuro: 6 (2)
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March/April 2019
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An ATF3-CreERT2 Knock-In Mouse for Axotomy-Induced Genetic Editing: Proof of Principle
Seth D. Holland, Leanne M. Ramer, Stephen B. McMahon, Franziska Denk, Matt S. Ramer
eNeuro 28 March 2019, 6 (2) ENEURO.0025-19.2019; DOI: 10.1523/ENEURO.0025-19.2019

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An ATF3-CreERT2 Knock-In Mouse for Axotomy-Induced Genetic Editing: Proof of Principle
Seth D. Holland, Leanne M. Ramer, Stephen B. McMahon, Franziska Denk, Matt S. Ramer
eNeuro 28 March 2019, 6 (2) ENEURO.0025-19.2019; DOI: 10.1523/ENEURO.0025-19.2019
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Keywords

  • Activating Transcription Factor 3
  • gene editing
  • peripheral nerve
  • Schwann cells
  • sensory neurons
  • spinal cord injury

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