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Research ArticleNew Research, Neuronal Excitability

Sensory Neurons of the Dorsal Root Ganglia Become Hyperexcitable in a T-Cell-Mediated MOG-EAE Model of Multiple Sclerosis

Muhammad Saad Yousuf, Myung-chul Noh, Timothy N. Friedman, Kasia Zubkow, John Christy Johnson, Gustavo Tenorio, Harley T. Kurata, Peter A. Smith and Bradley J. Kerr
eNeuro 20 March 2019, 6 (2) ENEURO.0024-19.2019; https://doi.org/10.1523/ENEURO.0024-19.2019
Muhammad Saad Yousuf
1Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
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  • ORCID record for Muhammad Saad Yousuf
Myung-chul Noh
2Department of Pharmacology, University of Alberta, Edmonton, Alberta T6E 2H7, Canada
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Timothy N. Friedman
1Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
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Kasia Zubkow
1Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
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John Christy Johnson
1Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
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Gustavo Tenorio
3Department of Anesthesiology and Pain Medicine, University of Alberta, Edmonton, Alberta T6G 2G3, Canada
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Harley T. Kurata
1Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
2Department of Pharmacology, University of Alberta, Edmonton, Alberta T6E 2H7, Canada
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Peter A. Smith
1Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
2Department of Pharmacology, University of Alberta, Edmonton, Alberta T6E 2H7, Canada
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Bradley J. Kerr
1Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
2Department of Pharmacology, University of Alberta, Edmonton, Alberta T6E 2H7, Canada
3Department of Anesthesiology and Pain Medicine, University of Alberta, Edmonton, Alberta T6G 2G3, Canada
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0024-19.2019
PubMed 
30957012
Published By 
Society for Neuroscience
History 
  • Received January 14, 2019
  • Revision received February 26, 2019
  • Accepted March 11, 2019
  • Published online March 20, 2019.
Copyright & Usage 
Copyright © 2019 Yousuf et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Muhammad Saad Yousuf1,
  2. Myung-chul Noh2,
  3. Timothy N. Friedman1,
  4. Kasia Zubkow1,
  5. John Christy Johnson1,
  6. Gustavo Tenorio3,
  7. Harley T. Kurata1,2,
  8. Peter A. Smith1,2 and
  9. Bradley J. Kerr1,2,3
  1. 1Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
  2. 2Department of Pharmacology, University of Alberta, Edmonton, Alberta T6E 2H7, Canada
  3. 3Department of Anesthesiology and Pain Medicine, University of Alberta, Edmonton, Alberta T6G 2G3, Canada
  1. Correspondence should be addressed to Bradley J. Kerr at bradley.kerr{at}ualberta.ca.
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Author contributions

  1. Author contributions: M.S.Y., P.A.S., and B.J.K. designed research; M.S.Y., M.-c.N., T.N.F., K.Z., and J.C.J. performed research; M.S.Y., M.-c.N., T.N.F., K.Z., J.C.J., G.T., and H.T.K. analyzed data; M.S.Y. and B.J.K. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the Gouvernement du Canada Canadian Institutes of Health Research Grants MOP-86712 and MOP-86712, the University of Alberta Hospital Fund, the MS Society of Canada, the Gouvernement du Canada Natural Sciences and Engineering Research Council (NSERC) Canada Foundation for Innovation, and the Alberta Advanced Technology and Education. M.S.Y. was supported by the Alexander Graham Bell Canada Graduate Scholarship from NSERC.

Funding

  • Gouvernement du Canada | Canadian Institutes of Health Research (CIHR)

    MOP-86712; MOP-86712
  • University of Alberta Hospital Fund

  • MS Society of Canada

  • Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (NSERC)

    CFI
  • Alberta Advanced Technology and Education

Other Version

  • You are viewing the most recent version of this article.
  • previous version (March 20, 2019).

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AbstractFullPdf
Mar 2019326085
Apr 2019864375193
May 201910014767
Jun 20192915129
Jul 20192919035
Aug 20192816942
Oct 2019814629
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Total 201913981405569
Jan 202096957
Feb 202076372
Mar 2020205641
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Jun 2020126477
Jul 2020613559
Aug 202063938
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Jan 2021810152
Feb 202198737
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Jul 2021108838
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Total 20211501124525
Jan 2022510945
Feb 202267762
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Apr 2022410634
May 2022411845
Jun 202207531
Jul 202236725
Aug 202235729
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Total 2022541038447
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May 202356632
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Jul 202377154
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Total 202399921369
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Jul 2025911352
Aug 2025612735
Sep 20251416430
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Nov 20251411726
Dec 20251112633
Total 20251121289350
Jan 20261414953
Feb 20261011823
Total 20262426776
Total218778183390
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Sensory Neurons of the Dorsal Root Ganglia Become Hyperexcitable in a T-Cell-Mediated MOG-EAE Model of Multiple Sclerosis
Muhammad Saad Yousuf, Myung-chul Noh, Timothy N. Friedman, Kasia Zubkow, John Christy Johnson, Gustavo Tenorio, Harley T. Kurata, Peter A. Smith, Bradley J. Kerr
eNeuro 20 March 2019, 6 (2) ENEURO.0024-19.2019; DOI: 10.1523/ENEURO.0024-19.2019

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Sensory Neurons of the Dorsal Root Ganglia Become Hyperexcitable in a T-Cell-Mediated MOG-EAE Model of Multiple Sclerosis
Muhammad Saad Yousuf, Myung-chul Noh, Timothy N. Friedman, Kasia Zubkow, John Christy Johnson, Gustavo Tenorio, Harley T. Kurata, Peter A. Smith, Bradley J. Kerr
eNeuro 20 March 2019, 6 (2) ENEURO.0024-19.2019; DOI: 10.1523/ENEURO.0024-19.2019
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Keywords

  • DRG
  • EAE
  • electrophysiology
  • MS
  • pain

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