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Research ArticleNew Research, Neuronal Excitability

A Poly-Glutamine Region in the Drosophila VAChT Dictates Fill-Level of Cholinergic Synaptic Vesicles

Samuel W. Vernon, Jim Goodchild and Richard A. Baines
eNeuro 12 February 2019, 6 (1) ENEURO.0477-18.2019; https://doi.org/10.1523/ENEURO.0477-18.2019
Samuel W. Vernon
1Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, United Kingdom
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Jim Goodchild
2Syngenta Ltd, Bracknell, Berkshire RG42 6EY, United Kingdom
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Richard A. Baines
1Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, United Kingdom
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0477-18.2019
PubMed 
30847389
Published By 
Society for Neuroscience
History 
  • Received December 7, 2018
  • Revision received January 3, 2019
  • Accepted January 7, 2019
  • Published online February 12, 2019.
Copyright & Usage 
Copyright © 2019 Vernon et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Samuel W. Vernon1,
  2. Jim Goodchild2 and
  3. Richard A. Baines1
  1. 1Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, United Kingdom
  2. 2Syngenta Ltd, Bracknell, Berkshire RG42 6EY, United Kingdom
  1. Correspondence should be addressed to Richard A. Baines at richard.baines{at}manchester.ac.uk.
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Author contributions

  1. Author contributions: S.W.V. and R.B. designed research; S.W.V. performed research; S.W.V. analyzed data; S.W.V., J.G., and R.B. wrote the paper.

Disclosures

  • Conflict of Interest Statement: S.W.V. and J.G. received financial support from Syngenta Ltd. Syngenta also contributed to study design and the preparation of the manuscript, but did not have any role in data collection, data analysis, or decision to publish. R.A.B. declares no competing financial interests.

  • This work was supported by the Biotechnology and Biological Sciences Research Council (BBSRC) Grant BB/L027690/1 (to R.A.B.), a BBSRC CASE studentship (S.W.V.). Work on this project benefited from the Manchester Fly Facility, established through funds from University and the Wellcome Trust (087742/Z/08/Z).

Funding

  • Biotechnology and Biological Sciences Research Council (BBSRC)

    BB/L027690/1
  • Wellcome Trust (Wellcome)

    087742/Z/08/Z

Other Version

  • You are viewing the most recent version of this article.
  • previous version (February 12, 2019).

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Feb 2019431035
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Total11514288898
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January/February 2019
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A Poly-Glutamine Region in the Drosophila VAChT Dictates Fill-Level of Cholinergic Synaptic Vesicles
Samuel W. Vernon, Jim Goodchild, Richard A. Baines
eNeuro 12 February 2019, 6 (1) ENEURO.0477-18.2019; DOI: 10.1523/ENEURO.0477-18.2019

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A Poly-Glutamine Region in the Drosophila VAChT Dictates Fill-Level of Cholinergic Synaptic Vesicles
Samuel W. Vernon, Jim Goodchild, Richard A. Baines
eNeuro 12 February 2019, 6 (1) ENEURO.0477-18.2019; DOI: 10.1523/ENEURO.0477-18.2019
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Keywords

  • Acetylcholine
  • Drosophila
  • neurotransmitter
  • synapse
  • synaptic vesicle
  • transporter

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