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Research ArticleNew Research, Integrative Systems

Estradiol-Induced Potentiation of Dopamine Release in Dorsal Striatum Following Amphetamine Administration Requires Estradiol Receptors and mGlu5

Zhimin Song, Hongyan Yang, Elizabeth M. Peckham and Jill B. Becker
eNeuro 29 January 2019, 6 (1) ENEURO.0446-18.2019; https://doi.org/10.1523/ENEURO.0446-18.2019
Zhimin Song
1Molecular and Behavioral Neuroscience Institute
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Hongyan Yang
3Department of Psychiatry and Biobehavioral Science, Semel Institute for Neuroscience and Human Behavior, and Hatos Center for Neuropharmacology, University of California, Los Angeles, California 90095
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Elizabeth M. Peckham
4Department of Biology, Concordia University, Ann Arbor, Michigan 48105
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Jill B. Becker
1Molecular and Behavioral Neuroscience Institute
2Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109
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    Figure 1

    Schematic diagram of all the treatments in each experiment.

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    Figure 2

    E2 in the DLS or EB, subcutaneously, potentiates DA release following AMPH injections. E2 was dissolved in Ringer’s solution and was infused into the DLS via reverse microdialysis. *indicates a significant difference between rats treated with E2 or EB and control rats.

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    Figure 3

    ICI infused into the DLS reduces E2-induced DA potentiation following AMPH injections. *indicates a significant difference between rats treated with ICI and control rats.

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    Figure 4

    MPEP reduces E2-induced DA potentiation following AMPH injections. *indicates a significant difference between rats treated with MPEP and control rats.

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    Figure 5

    Neither ICI or MPEP influences DA release in the DLS when estradiol was not administered. These rats were ovariectomized and were not given EB injections or E2 infusions.

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    Table 1

    : Comparisons of DA release in response to AMPH among rats with varying pretreatments in Experiments 1–3

    ANOVA tests comparing rats treated with EB, E2, and Vehicle in Experiment 1
        Time post-AMPH, min10203040
        F valueF(2,25) = 1.853F(2,25) = 4.433F(2,25) = =5.045F(2,25) = 3.939
        p value0.1780.0230.0140.033
    Planned contrast tests
        Time post-AMPH, min10203040
        p Value, Control vs EBNA0.0370.0830.233
        p Value, Control vs E2NA0.0130.0050.010
    Mann-Whitney U tests comparing rats treated with EB and ICI+EB in Experiment 2
        Time post-AMPH, min10203040
        U14.00014.00012.0009.000
        p value0.0340.0340.0210.009
    Independent tests comparing rats treated with E2 and E2+MPEP in Experiment 3
        Time post-AMPH, min10203040
        t valuet(16) = 1.410t(16) = 2.790t(16) = 2.232t(16) = 1.993
        p value0.1780.0130.0400.064
    • Values in bold indicate significant differences.

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January/February 2019
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Estradiol-Induced Potentiation of Dopamine Release in Dorsal Striatum Following Amphetamine Administration Requires Estradiol Receptors and mGlu5
Zhimin Song, Hongyan Yang, Elizabeth M. Peckham, Jill B. Becker
eNeuro 29 January 2019, 6 (1) ENEURO.0446-18.2019; DOI: 10.1523/ENEURO.0446-18.2019

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Estradiol-Induced Potentiation of Dopamine Release in Dorsal Striatum Following Amphetamine Administration Requires Estradiol Receptors and mGlu5
Zhimin Song, Hongyan Yang, Elizabeth M. Peckham, Jill B. Becker
eNeuro 29 January 2019, 6 (1) ENEURO.0446-18.2019; DOI: 10.1523/ENEURO.0446-18.2019
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Keywords

  • addiction
  • drug abuse
  • gonadal hormones
  • reward
  • sex difference

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