Skip to main content

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Blog
    • Collections
    • Podcast
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • ABOUT
    • Overview
    • Editorial Board
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
  • SUBMIT

User menu

Search

  • Advanced search
eNeuro

eNeuro

Advanced Search

 

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Blog
    • Collections
    • Podcast
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • ABOUT
    • Overview
    • Editorial Board
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
  • SUBMIT
PreviousNext
Research ArticleNew Research, Integrative Systems

Estradiol-Induced Potentiation of Dopamine Release in Dorsal Striatum Following Amphetamine Administration Requires Estradiol Receptors and mGlu5

Zhimin Song, Hongyan Yang, Elizabeth M. Peckham and Jill B. Becker
eNeuro 29 January 2019, 6 (1) ENEURO.0446-18.2019; DOI: https://doi.org/10.1523/ENEURO.0446-18.2019
Zhimin Song
1Molecular and Behavioral Neuroscience Institute
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hongyan Yang
3Department of Psychiatry and Biobehavioral Science, Semel Institute for Neuroscience and Human Behavior, and Hatos Center for Neuropharmacology, University of California, Los Angeles, California 90095
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Elizabeth M. Peckham
4Department of Biology, Concordia University, Ann Arbor, Michigan 48105
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jill B. Becker
1Molecular and Behavioral Neuroscience Institute
2Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Figures & Data

Figures

  • Tables
  • Figure 1
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 1

    Schematic diagram of all the treatments in each experiment.

  • Figure 2
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 2

    E2 in the DLS or EB, subcutaneously, potentiates DA release following AMPH injections. E2 was dissolved in Ringer’s solution and was infused into the DLS via reverse microdialysis. *indicates a significant difference between rats treated with E2 or EB and control rats.

  • Figure 3
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 3

    ICI infused into the DLS reduces E2-induced DA potentiation following AMPH injections. *indicates a significant difference between rats treated with ICI and control rats.

  • Figure 4
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 4

    MPEP reduces E2-induced DA potentiation following AMPH injections. *indicates a significant difference between rats treated with MPEP and control rats.

  • Figure 5
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 5

    Neither ICI or MPEP influences DA release in the DLS when estradiol was not administered. These rats were ovariectomized and were not given EB injections or E2 infusions.

Tables

  • Figures
    • View popup
    Table 1

    : Comparisons of DA release in response to AMPH among rats with varying pretreatments in Experiments 1–3

    ANOVA tests comparing rats treated with EB, E2, and Vehicle in Experiment 1
        Time post-AMPH, min10203040
        F valueF(2,25) = 1.853F(2,25) = 4.433F(2,25) = =5.045F(2,25) = 3.939
        p value0.1780.0230.0140.033
    Planned contrast tests
        Time post-AMPH, min10203040
        p Value, Control vs EBNA0.0370.0830.233
        p Value, Control vs E2NA0.0130.0050.010
    Mann-Whitney U tests comparing rats treated with EB and ICI+EB in Experiment 2
        Time post-AMPH, min10203040
        U14.00014.00012.0009.000
        p value0.0340.0340.0210.009
    Independent tests comparing rats treated with E2 and E2+MPEP in Experiment 3
        Time post-AMPH, min10203040
        t valuet(16) = 1.410t(16) = 2.790t(16) = 2.232t(16) = 1.993
        p value0.1780.0130.0400.064
    • Values in bold indicate significant differences.

Back to top

In this issue

eneuro: 6 (1)
eNeuro
Vol. 6, Issue 1
January/February 2019
  • Table of Contents
  • Index by author
  • Ed Board (PDF)
Email

Thank you for sharing this eNeuro article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Estradiol-Induced Potentiation of Dopamine Release in Dorsal Striatum Following Amphetamine Administration Requires Estradiol Receptors and mGlu5
(Your Name) has forwarded a page to you from eNeuro
(Your Name) thought you would be interested in this article in eNeuro.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Citation Tools
Estradiol-Induced Potentiation of Dopamine Release in Dorsal Striatum Following Amphetamine Administration Requires Estradiol Receptors and mGlu5
Zhimin Song, Hongyan Yang, Elizabeth M. Peckham, Jill B. Becker
eNeuro 29 January 2019, 6 (1) ENEURO.0446-18.2019; DOI: 10.1523/ENEURO.0446-18.2019

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Share
Estradiol-Induced Potentiation of Dopamine Release in Dorsal Striatum Following Amphetamine Administration Requires Estradiol Receptors and mGlu5
Zhimin Song, Hongyan Yang, Elizabeth M. Peckham, Jill B. Becker
eNeuro 29 January 2019, 6 (1) ENEURO.0446-18.2019; DOI: 10.1523/ENEURO.0446-18.2019
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Significance Statement
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Conclusion
    • Footnotes
    • Reference
    • Synthesis
    • Author Response
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • addiction
  • drug abuse
  • gonadal hormones
  • reward
  • sex difference

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

New Research

  • Allopregnanolone effects on inhibition in hippocampal parvalbumin interneurons
  • LINCs are vulnerable to epileptic insult and fail to provide seizure control via on-demand activation
  • Pregabalin silences oxaliplatin-activated sensory neurons to relieve cold allodynia
Show more New Research

Integrative Systems

  • Juvenile Shank3 KO Mice Adopt Distinct Hunting Strategies during Prey Capture Learning
  • P2X7 Receptor and Purinergic Signaling: Orchestrating Mitochondrial Dysfunction in Neurodegenerative Diseases
  • Development of an Open Face Home Cage Running Wheel for Testing Activity-Based Anorexia and Other Applications
Show more Integrative Systems

Subjects

  • Integrative Systems

  • Home
  • Alerts
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Latest Articles
  • Issue Archive
  • Blog
  • Browse by Topic

Information

  • For Authors
  • For the Media

About

  • About the Journal
  • Editorial Board
  • Privacy Policy
  • Contact
  • Feedback
(eNeuro logo)
(SfN logo)

Copyright © 2023 by the Society for Neuroscience.
eNeuro eISSN: 2373-2822

The ideas and opinions expressed in eNeuro do not necessarily reflect those of SfN or the eNeuro Editorial Board. Publication of an advertisement or other product mention in eNeuro should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in eNeuro.