Figure 1. GABAA receptor modulators increase susceptibility to FSs in P11 mouse. A, Experimental timeline of the induction of prolonged FSs. B, The elevation pattern of temperature during hyperthermia with the treatment of saline, pentobarbital, diazepam, and bumetanide; n = 4–5 mice. C, The incidence of clonus seizures per mouse with the treatment of saline, pentobarbital, diazepam, and bumetanide; n = 4–5 mice (saline, 5/5; 0.01 mg/kg diazepam, 0/4; 1 mg/kg diazepam, 5/5; 1 mg/kg diazepam + 10 mg/kg bumetanide, 0/5; 0.37 mg/kg pentobarbital, 5/5; 37 mg/kg pentobarbital, 5/5; 37 mg/kg pentobarbital + 10 mg/kg bumetanide, 1/5; 10 mg/kg bumetanide, 2/4). D, Normalized duration of clonus seizures induced by hyperthermia. Data represent the mean ± SEM. *p < 0.05, **p < 0.01, Tukey’s test; n = 4–5 mice. E, Latency of clonus seizures induced by hyperthermia. Data represent the mean ± SEM. *p < 0.05, **p < 0.01 versus saline, Tukey’s test; n = 5 mice. F, Threshold temperature of clonus seizures induced by hyperthermia. Data represent the mean ± SEM. **p < 0.01 versus saline, Tukey’s test; n = 5 mice.