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Research ArticleNew Research, Cognition and Behavior

Aerobic Glycolysis Is Required for Spatial Memory Acquisition But Not Memory Retrieval in Mice

Richard A. Harris, Asad Lone, Heeseung Lim, Francisco Martinez, Ariel K. Frame, Timothy J. Scholl and Robert C. Cumming
eNeuro 11 February 2019, 6 (1) ENEURO.0389-18.2019; DOI: https://doi.org/10.1523/ENEURO.0389-18.2019
Richard A. Harris
1Department of Biology, University of Western Ontario, London, Ontario N6A 5B7, Canada
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Asad Lone
1Department of Biology, University of Western Ontario, London, Ontario N6A 5B7, Canada
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Heeseung Lim
2Department of Medical Biophysics, University of Western Ontario, London, Ontario N6A 5C1, Canada
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Francisco Martinez
3Robarts Research Institute, University of Western Ontario, London, Ontario N6A 3K7, Canada
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Ariel K. Frame
1Department of Biology, University of Western Ontario, London, Ontario N6A 5B7, Canada
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Timothy J. Scholl
2Department of Medical Biophysics, University of Western Ontario, London, Ontario N6A 5C1, Canada
3Robarts Research Institute, University of Western Ontario, London, Ontario N6A 3K7, Canada
4 Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada
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Robert C. Cumming
1Department of Biology, University of Western Ontario, London, Ontario N6A 5B7, Canada
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0389-18.2019
PubMed 
30809587
Published By 
Society for Neuroscience
History 
  • Received October 3, 2018
  • Revision received January 23, 2019
  • Accepted January 26, 2019
  • Published online February 11, 2019.
Copyright & Usage 
Copyright © 2019 Harris et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Richard A. Harris1,*,
  2. Asad Lone1,*,
  3. Heeseung Lim2,
  4. Francisco Martinez3,
  5. Ariel K. Frame1,
  6. Timothy J. Scholl2,3,4 and
  7. Robert C. Cumming1
  1. 1Department of Biology, University of Western Ontario, London, Ontario N6A 5B7, Canada
  2. 2Department of Medical Biophysics, University of Western Ontario, London, Ontario N6A 5C1, Canada
  3. 3Robarts Research Institute, University of Western Ontario, London, Ontario N6A 3K7, Canada
  4. 4 Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada
  1. Correspondence should be addressed to Robert C. Cumming at rcummin5{at}uwo.ca.
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Author contributions

  1. R.A.H., T.J.S., and R.C.C. designed research; R.A.H., A.L., H.L., F.M., and A.K.F. performed research; R.A.H., A.L., and R.C.C. analyzed data; R.A.H., A.L., and R.C.C. wrote the paper.

  2. ↵* R.A.H. and A.L. contributed equally to this work.

Disclosures

  • The authors declare no competing financial interests.

  • This research was supported by Natural Sciences and Engineering Research Council of Canada Grants 355803-2013 (R.C.C.) and 06338-2017 (T.J.S.), Scottish Rite Charitable Foundation Grant 11103 (R.C.C.), Canada Foundation for Innovation Grant 22167 (R.C.C.), and Canadian Consortium on Neurodegeneration in Aging Grant 137794 (R.C.C.).

Funding

  • Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (NSERC)

    355803-2013; 06338-2017
  • Canadian Consortium on Neurodegeneration in Aging

    137794
  • Scottish Rite Charitable Foundation of Canada (SRCFC)

    11103
  • Canada Foundation for Innovation (CFI)

    22167

Other Version

  • You are viewing the most recent version of this article.
  • previous version (February 11, 2019).

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Feb 201971191104
Mar 201930833650
Apr 20195422219
May 20193320829
Jun 20192417316
Jul 20191626026
Aug 20191542226
Oct 20191137716
Nov 20191225417
Dec 2019917217
Total 201911932515320
Jan 202069022
Feb 202096327
Mar 202068128
May 202046529
Jun 202028621
Jul 202035631
Aug 202064233
Sep 202034718
Oct 202026125
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Apr 202116116
May 202157819
Jun 20213508
Jul 202115717
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Total 202130861273
Jan 202247517
Feb 202225418
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Apr 202214214
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Jun 202206723
Jul 202225713
Aug 202245222
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Oct 202254924
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Total 202231653219
Jan 202325721
Feb 202305912
Mar 20230438
Apr 202305011
May 202314818
Total 2023325770
Total130950351152
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Aerobic Glycolysis Is Required for Spatial Memory Acquisition But Not Memory Retrieval in Mice
Richard A. Harris, Asad Lone, Heeseung Lim, Francisco Martinez, Ariel K. Frame, Timothy J. Scholl, Robert C. Cumming
eNeuro 11 February 2019, 6 (1) ENEURO.0389-18.2019; DOI: 10.1523/ENEURO.0389-18.2019

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Aerobic Glycolysis Is Required for Spatial Memory Acquisition But Not Memory Retrieval in Mice
Richard A. Harris, Asad Lone, Heeseung Lim, Francisco Martinez, Ariel K. Frame, Timothy J. Scholl, Robert C. Cumming
eNeuro 11 February 2019, 6 (1) ENEURO.0389-18.2019; DOI: 10.1523/ENEURO.0389-18.2019
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Keywords

  • aerobic glycolysis
  • lactate
  • magnetic resonance spectroscopy
  • memory
  • metabolism
  • synaptic plasticity

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