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Research ArticleNew Research, Disorders of the Nervous System

An Adenosine A2A Receptor Antagonist Improves Multiple Symptoms of Repeated Quinpirole-Induced Psychosis

Nozomi Asaoka, Naoya Nishitani, Haruko Kinoshita, Yuma Nagai, Hikari Hatakama, Kazuki Nagayasu, Hisashi Shirakawa, Takayuki Nakagawa and Shuji Kaneko
eNeuro 19 February 2019, 6 (1) ENEURO.0366-18.2019; https://doi.org/10.1523/ENEURO.0366-18.2019
Nozomi Asaoka
1Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan
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  • ORCID record for Nozomi Asaoka
Naoya Nishitani
1Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan
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Haruko Kinoshita
1Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan
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Yuma Nagai
1Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan
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Hikari Hatakama
1Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan
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Kazuki Nagayasu
1Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan
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Hisashi Shirakawa
1Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan
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Takayuki Nakagawa
2Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Sakyo-ku, Kyoto 606-8507, Japan
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Shuji Kaneko
1Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0366-18.2019
PubMed 
30834304
Published By 
Society for Neuroscience
History 
  • Received September 20, 2018
  • Revision received January 18, 2019
  • Accepted January 26, 2019
  • Published online February 19, 2019.
Copyright & Usage 
Copyright © 2019 Asaoka et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Nozomi Asaoka1,
  2. Naoya Nishitani1,
  3. Haruko Kinoshita1,
  4. Yuma Nagai1,
  5. Hikari Hatakama1,
  6. Kazuki Nagayasu1,
  7. Hisashi Shirakawa1,
  8. Takayuki Nakagawa2 and
  9. Shuji Kaneko1
  1. 1Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan
  2. 2Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Sakyo-ku, Kyoto 606-8507, Japan
  1. Correspondence should be addressed to Kazuki Nagayasu at nagayasu{at}pharm.kyoto-u.ac.jp or Shuji Kaneko at skaneko{at}pharm.kyoto-u.ac.jp.
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Author contributions

  1. Author contributions: N.A., K.N., H.S., T.N., and S.K. designed research; N.A., H.K., and H.H. performed research; N.A., N.N., H.K., Y.N., and H.H. analyzed data; N.A., K.N., and S.K. wrote the paper; N.N. and Y.N. contributed unpublished reagents/analytic tools.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the Japanese Society for the Promotion of Science (JSPS) Grant-in-Aid for Scientific Research (KAKENHI) 16H05091 (to K.N., H.S., T.N., and S.K.) and the Japan Agency for Medical Research and Development (AMED) Grant 18ak0101088h0001 (to S.K.).

Funding

  • Japanese Society for the Promotion of Science (JSPS)

    16H05091
  • Japan Agency for Medical Research and Development (AMED)

    18ak0101088h0001

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  • You are viewing the most recent version of this article.
  • previous version (February 19, 2019).

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Mar 2019750621127
Apr 20197411130
May 20194515428
Jun 2019219018
Jul 2019176333
Aug 2019196725
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Jan 202084518
Feb 202083921
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Total 202056517179
Jan 202127328
Feb 202125413
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Total 202536372122
Total139647261535
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An Adenosine A2A Receptor Antagonist Improves Multiple Symptoms of Repeated Quinpirole-Induced Psychosis
Nozomi Asaoka, Naoya Nishitani, Haruko Kinoshita, Yuma Nagai, Hikari Hatakama, Kazuki Nagayasu, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kaneko
eNeuro 19 February 2019, 6 (1) ENEURO.0366-18.2019; DOI: 10.1523/ENEURO.0366-18.2019

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An Adenosine A2A Receptor Antagonist Improves Multiple Symptoms of Repeated Quinpirole-Induced Psychosis
Nozomi Asaoka, Naoya Nishitani, Haruko Kinoshita, Yuma Nagai, Hikari Hatakama, Kazuki Nagayasu, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kaneko
eNeuro 19 February 2019, 6 (1) ENEURO.0366-18.2019; DOI: 10.1523/ENEURO.0366-18.2019
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Keywords

  • D2 receptor
  • obsessive-compulsive disorder

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