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Research ArticleNegative Results, Disorders of the Nervous System

Deletion of Ripk3 Prevents Motor Neuron Death In Vitro but not In Vivo

Georgia Dermentzaki, Kristin A. Politi, Lei Lu, Vartika Mishra, Eduardo J. Pérez-Torres, Alexander A. Sosunov, Guy M. McKhann II, Francesco Lotti, Neil A. Shneider and Serge Przedborski
eNeuro 28 January 2019, 6 (1) ENEURO.0308-18.2018; DOI: https://doi.org/10.1523/ENEURO.0308-18.2018
Georgia Dermentzaki
1Department of Pathology and Cell Biology, Columbia University, New York, NY 10032
4Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032
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Kristin A. Politi
1Department of Pathology and Cell Biology, Columbia University, New York, NY 10032
4Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032
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Lei Lu
2Department of Neurology, Columbia University, New York, NY 10032
4Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032
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Vartika Mishra
1Department of Pathology and Cell Biology, Columbia University, New York, NY 10032
4Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032
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Eduardo J. Pérez-Torres
1Department of Pathology and Cell Biology, Columbia University, New York, NY 10032
4Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032
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Alexander A. Sosunov
3Department of Neurological Surgery, Columbia University, New York, NY 10032
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Guy M. McKhann II
3Department of Neurological Surgery, Columbia University, New York, NY 10032
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Francesco Lotti
1Department of Pathology and Cell Biology, Columbia University, New York, NY 10032
4Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032
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Neil A. Shneider
2Department of Neurology, Columbia University, New York, NY 10032
4Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032
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Serge Przedborski
1Department of Pathology and Cell Biology, Columbia University, New York, NY 10032
2Department of Neurology, Columbia University, New York, NY 10032
4Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032
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Deletion of Ripk3 Prevents Motor Neuron Death In Vitro but not In Vivo
Georgia Dermentzaki, Kristin A. Politi, Lei Lu, Vartika Mishra, Eduardo J. Pérez-Torres, Alexander A. Sosunov, Guy M. McKhann, Francesco Lotti, Neil A. Shneider, Serge Przedborski
eNeuro 28 January 2019, 6 (1) ENEURO.0308-18.2018; DOI: 10.1523/ENEURO.0308-18.2018

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Deletion of Ripk3 Prevents Motor Neuron Death In Vitro but not In Vivo
Georgia Dermentzaki, Kristin A. Politi, Lei Lu, Vartika Mishra, Eduardo J. Pérez-Torres, Alexander A. Sosunov, Guy M. McKhann, Francesco Lotti, Neil A. Shneider, Serge Przedborski
eNeuro 28 January 2019, 6 (1) ENEURO.0308-18.2018; DOI: 10.1523/ENEURO.0308-18.2018
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Keywords

  • ALS
  • mice
  • motor neuron
  • necroptosis
  • neurodegeneration
  • Ripk3

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