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Research ArticleNegative Results, Disorders of the Nervous System

Deletion of Ripk3 Prevents Motor Neuron Death In Vitro but not In Vivo

Georgia Dermentzaki, Kristin A. Politi, Lei Lu, Vartika Mishra, Eduardo J. Pérez-Torres, Alexander A. Sosunov, Guy M. McKhann II, Francesco Lotti, Neil A. Shneider and Serge Przedborski
eNeuro 28 January 2019, 6 (1) ENEURO.0308-18.2018; DOI: https://doi.org/10.1523/ENEURO.0308-18.2018
Georgia Dermentzaki
1Department of Pathology and Cell Biology, Columbia University, New York, NY 10032
4Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032
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Kristin A. Politi
1Department of Pathology and Cell Biology, Columbia University, New York, NY 10032
4Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032
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Lei Lu
2Department of Neurology, Columbia University, New York, NY 10032
4Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032
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Vartika Mishra
1Department of Pathology and Cell Biology, Columbia University, New York, NY 10032
4Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032
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Eduardo J. Pérez-Torres
1Department of Pathology and Cell Biology, Columbia University, New York, NY 10032
4Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032
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Alexander A. Sosunov
3Department of Neurological Surgery, Columbia University, New York, NY 10032
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Guy M. McKhann II
3Department of Neurological Surgery, Columbia University, New York, NY 10032
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Francesco Lotti
1Department of Pathology and Cell Biology, Columbia University, New York, NY 10032
4Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032
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Neil A. Shneider
2Department of Neurology, Columbia University, New York, NY 10032
4Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032
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Serge Przedborski
1Department of Pathology and Cell Biology, Columbia University, New York, NY 10032
2Department of Neurology, Columbia University, New York, NY 10032
4Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0308-18.2018
PubMed 
30815534
Published By 
Society for Neuroscience
History 
  • Received August 3, 2018
  • Revision received December 14, 2018
  • Accepted December 14, 2018
  • Published online January 28, 2019.
Copyright & Usage 
Copyright © 2019 Dermentzaki et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Georgia Dermentzaki1,4,^,
  2. Kristin A. Politi1,4,^,
  3. Lei Lu2,4,^,
  4. Vartika Mishra1,4,
  5. Eduardo J. Pérez-Torres1,4,
  6. Alexander A. Sosunov3,
  7. Guy M. McKhann II3,
  8. Francesco Lotti1,4,
  9. Neil A. Shneider2,4 and
  10. Serge Przedborski1,2,4
  1. 1Department of Pathology and Cell Biology, Columbia University, New York, NY 10032
  2. 2Department of Neurology, Columbia University, New York, NY 10032
  3. 3Department of Neurological Surgery, Columbia University, New York, NY 10032
  4. 4Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032
  1. Correspondence should be addressed to Serge Przedborski at sp30{at}cumc.columbia.edu.
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Author contributions

  1. Author contributions: F.L., N.A.S., and S.P. designed research; G.D., K.A.P., L.L., V.M., E.J.P.-T., and A.A.S. performed research; G.M.M. contributed unpublished reagents/analytic tools; G.D., K.A.P., F.L., and S.P. analyzed data; G.D., K.A.P, F.L., N.A.S. and S.P. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by National Institute of Neurological Disorders and Stroke Grants NS099862, NS072428, and NS107442 (to S.P.), NS101966 (to E.J.P.-T.), NS101575 (to F.L.), and NS073776 (to L.L. and N.A.S.); the United States Department of Defense Award W81XWH-13-1-0416 (to S.P.); the Project-ALS/Columbia University Preclinical Core (F.L., N.A.S, and S.P.); Innovation Awards from the Thompson Family Foundation Initiative (S.P. and F.L.); the National Science Foundation Grant DGE 1644869 (to K.A.P.); the National Institutes of Health and National Center for Advancing Translational Sciences Grant TL1 TR000082-07 (to K.A.P.); the Medical Scientist Training Program GM007367 (to E.J.P.-T.); and the ALS Therapy Alliance (L.L. and N.A.S.).

  • ↵^ G.D., K.A.P., and L.L. have equally contributed to this work.

Funding

  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    NS099862; NS107442; NS101966; NS101575; NS073776
  • US Department of Defense Award

    W81XWH-13-1-0416
  • Project ALS/Columbia University Preclinical Core

  • Innovation Awards from the Thompson Family Foundation Initiative

  • National Science Foundation (NSF)

    DGE 1644869
  • National Institute of Health and National Center for Advancing Translational Sciences

    TL1 TR000082-07
  • Medical Scientist Training Program

    GM007367
  • ALS Therapy Alliance

Other Version

  • previous version (January 28, 2019).
  • You are viewing the most recent version of this article.

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Deletion of Ripk3 Prevents Motor Neuron Death In Vitro but not In Vivo
Georgia Dermentzaki, Kristin A. Politi, Lei Lu, Vartika Mishra, Eduardo J. Pérez-Torres, Alexander A. Sosunov, Guy M. McKhann, Francesco Lotti, Neil A. Shneider, Serge Przedborski
eNeuro 28 January 2019, 6 (1) ENEURO.0308-18.2018; DOI: 10.1523/ENEURO.0308-18.2018

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Deletion of Ripk3 Prevents Motor Neuron Death In Vitro but not In Vivo
Georgia Dermentzaki, Kristin A. Politi, Lei Lu, Vartika Mishra, Eduardo J. Pérez-Torres, Alexander A. Sosunov, Guy M. McKhann, Francesco Lotti, Neil A. Shneider, Serge Przedborski
eNeuro 28 January 2019, 6 (1) ENEURO.0308-18.2018; DOI: 10.1523/ENEURO.0308-18.2018
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Keywords

  • ALS
  • mice
  • motor neuron
  • necroptosis
  • neurodegeneration
  • Ripk3

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