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Research ArticleNew Research, Neuronal Excitability

Isoflurane Inhibits Dopaminergic Synaptic Vesicle Exocytosis Coupled to CaV2.1 and CaV2.2 in Rat Midbrain Neurons

Christina L. Torturo, Zhen-Yu Zhou, Timothy A. Ryan and Hugh C. Hemmings
eNeuro 10 January 2019, 6 (1) ENEURO.0278-18.2018; https://doi.org/10.1523/ENEURO.0278-18.2018
Christina L. Torturo
1Department of Anesthesiology, Weill Cornell Medicine, New York, NY 10065
2Department of Pharmacology, Weill Cornell Medicine, New York, NY 10065
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Zhen-Yu Zhou
1Department of Anesthesiology, Weill Cornell Medicine, New York, NY 10065
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Timothy A. Ryan
1Department of Anesthesiology, Weill Cornell Medicine, New York, NY 10065
3Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065
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Hugh C. Hemmings
1Department of Anesthesiology, Weill Cornell Medicine, New York, NY 10065
2Department of Pharmacology, Weill Cornell Medicine, New York, NY 10065
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0278-18.2018
PubMed 
30680310
Published By 
Society for Neuroscience
History 
  • Received July 16, 2018
  • Revision received December 18, 2018
  • Accepted December 21, 2018
  • Published online January 10, 2019.
Copyright & Usage 
Copyright © 2019 Torturo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Christina L. Torturo1,2,
  2. Zhen-Yu Zhou1,
  3. Timothy A. Ryan1,3 and
  4. Hugh C. Hemmings1,2
  1. 1Department of Anesthesiology, Weill Cornell Medicine, New York, NY 10065
  2. 2Department of Pharmacology, Weill Cornell Medicine, New York, NY 10065
  3. 3Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065
  1. Correspondence should be addressed to Hugh C. Hemmings at hchemmi{at}med.cornell.edu.
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Author contributions

  1. Author contributions: C.L.T., Z.-Y.Z., T.A.R., and H.C.H. designed research; C.L.T. performed research; T.A.R. contributed unpublished reagents/analytic tools; C.L.T. and Z.-Y.Z. analyzed data; C.L.T., Z.-Y.Z., T.A.R., and H.C.H. wrote the paper.

Disclosures

  • H.C.H. is Editor-in-Chief of the British Journal of Anaesthesia and consultant for Elsevier. All other authors declare no competing financial interests.

  • This work was supported by the National Institutes of Health Grant GM58055 (to H.C.H.).

Funding

  • HHS | National Institutes of Health (NIH)

    GM58055

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  • previous version (January 10, 2019).

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AbstractFullPdf
Jan 20191185104383
Feb 201939047494
Mar 20198417334
Apr 20194111356
May 2019257021
Jun 2019127022
Jul 2019128928
Aug 2019106113
Oct 201954112
Nov 201966225
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Total 201917751293697
Jan 202044917
Feb 202044723
Mar 202012610
May 202034521
Jun 202054317
Jul 2020212116
Aug 20205429
Sep 202024613
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Nov 202017123
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Feb 202116113
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Apr 202156619
May 202126413
Jun 20211528
Jul 202156225
Aug 20210416
Sep 202126321
Oct 202117239
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Total 202133694200
Jan 202246117
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Apr 202223718
May 202215923
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Jan 202313717
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Aug 20245427
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Total 202423609138
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May 202515911
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Jul 202576715
Aug 202545637
Sep 2025411624
Oct 2025611926
Nov 2025109439
Dec 2025107620
Total 202557914259
Jan 202645910
Total 202645910
Total196353311853
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Isoflurane Inhibits Dopaminergic Synaptic Vesicle Exocytosis Coupled to CaV2.1 and CaV2.2 in Rat Midbrain Neurons
Christina L. Torturo, Zhen-Yu Zhou, Timothy A. Ryan, Hugh C. Hemmings
eNeuro 10 January 2019, 6 (1) ENEURO.0278-18.2018; DOI: 10.1523/ENEURO.0278-18.2018

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Isoflurane Inhibits Dopaminergic Synaptic Vesicle Exocytosis Coupled to CaV2.1 and CaV2.2 in Rat Midbrain Neurons
Christina L. Torturo, Zhen-Yu Zhou, Timothy A. Ryan, Hugh C. Hemmings
eNeuro 10 January 2019, 6 (1) ENEURO.0278-18.2018; DOI: 10.1523/ENEURO.0278-18.2018
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Keywords

  • anesthesia
  • calcium
  • dopamine
  • exocytosis
  • neuropharmacology
  • synaptic transmission

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