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Research ArticleNew Research, Cognition and Behavior

Adenosine Signaling through A1 Receptors Inhibits Chemosensitive Neurons in the Retrotrapezoid Nucleus

S. D. James, V. E. Hawkins, B. Falquetto, D. N. Ruskin, S. A. Masino, T. S. Moreira, M. L. Olsen and D. K. Mulkey
eNeuro 26 November 2018, 5 (6) ENEURO.0404-18.2018; DOI: https://doi.org/10.1523/ENEURO.0404-18.2018
S. D. James
1Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT
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V. E. Hawkins
1Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT
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B. Falquetto
1Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT
2Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil
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D. N. Ruskin
3Neuroscience Program, Department of Psychology, Trinity College Hartford, CT
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S. A. Masino
3Neuroscience Program, Department of Psychology, Trinity College Hartford, CT
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T. S. Moreira
4Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil
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M. L. Olsen
5School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA
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D. K. Mulkey
1Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0404-18.2018
PubMed 
30627640
Published By 
Society for Neuroscience
History 
  • Received October 18, 2018
  • Revision received November 13, 2018
  • Accepted November 16, 2018
  • Published online November 26, 2018.
Copyright & Usage 
Copyright © 2018 James et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. S. D. James1,
  2. V. E. Hawkins1,
  3. B. Falquetto1,2,
  4. D. N. Ruskin3,
  5. S. A. Masino3,
  6. T. S. Moreira4,
  7. M. L. Olsen5 and
  8. D. K. Mulkey1
  1. 1Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT
  2. 2Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil
  3. 3Neuroscience Program, Department of Psychology, Trinity College Hartford, CT
  4. 4Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil
  5. 5School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA
  1. Correspondence should be addressed to D. K. Mulkey, Professor of Physiology and Neurobiology, University of Connecticut, 75 North Eagleville Road, Storrs, CT 06269, E-mail: daniel.mulkey{at}uconn.edu.
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Author contributions

  1. Author contributions: S.A.M., T.S.M., M.L.O., and D.K.M. designed research; S.D.J., V.E.H., B.F., and D.N.R. performed research; S.D.J., V.E.H., B.F., D.N.R., S.A.M., M.L.O., and D.K.M. analyzed data; S.A.M., T.S.M., M.L.O., and D.K.M. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by National Institutes of Health Grants HL104101 (to D.K.M., M.L.O.), HL137094 (to D.K.M.), NS065957 (to S.A.M.), NS066392 (to S.A.M.), and AT008742 (to D.N.R.). Additional funds were also provided by the Dravet Foundation Grant AG180243 (to D.K.M.), the São Paulo Research Foundation Grants 2014/04866-5 (to B.F.), 2015/23376-1 (to T.S.M.), 2016/22069-0 (to T.S.M.), and Trinity College (S.A.M., D.N.R.).

Funding

  • HHS | National Institutes of Health (NIH)

    HL104101; HL137094; NS065957; NS066392; AT008742
  • Dravet Syndrome Foundation (DSF)

    AG180243
  • sao paulo research foundation

    2014/04866-5; 2015/23376-1; 2016/22069-0
  • Trinity college

Other Version

  • You are viewing the most recent version of this article.
  • previous version (November 26, 2018).

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Nov 2018110019
Dec 20184174746
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Jan 20191409721
Feb 201932545
Mar 20193227514
Apr 2019152279
May 2019915211
Jun 2019726214
Jul 20192241719
Aug 20191384316
Oct 20191171110
Nov 2019547511
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Total 20192923793141
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Feb 202081820
Mar 202043110
May 202033514
Jun 202023816
Jul 202012617
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Sep 20202349
Oct 202084111
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Feb 20214417
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Apr 20213475
May 202110609
Jun 202129538
Jul 202145112
Aug 20215542
Sep 20210418
Oct 202126024
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Total 202164662131
Jan 20220435
Feb 20224288
Mar 20222334
Apr 20223326
May 202214214
Jun 20220418
Jul 20224309
Aug 202203613
Sep 202232210
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Dec 202214011
Total 202222415118
Jan 202313510
Feb 20230358
Mar 20231394
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May 202303513
Jun 2023042
Total 2023319742
Total9525544656
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Adenosine Signaling through A1 Receptors Inhibits Chemosensitive Neurons in the Retrotrapezoid Nucleus
S. D. James, V. E. Hawkins, B. Falquetto, D. N. Ruskin, S. A. Masino, T. S. Moreira, M. L. Olsen, D. K. Mulkey
eNeuro 26 November 2018, 5 (6) ENEURO.0404-18.2018; DOI: 10.1523/ENEURO.0404-18.2018

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Adenosine Signaling through A1 Receptors Inhibits Chemosensitive Neurons in the Retrotrapezoid Nucleus
S. D. James, V. E. Hawkins, B. Falquetto, D. N. Ruskin, S. A. Masino, T. S. Moreira, M. L. Olsen, D. K. Mulkey
eNeuro 26 November 2018, 5 (6) ENEURO.0404-18.2018; DOI: 10.1523/ENEURO.0404-18.2018
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Keywords

  • brain slice
  • cellular
  • chemoreception
  • network
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