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Research ArticleNew Research, Integrative Systems

Coordination between Prefrontal Cortex Clock Gene Expression and Corticosterone Contributes to Enhanced Conditioned Fear Extinction Recall

Elizabeth R. Woodruff, Lauren E. Chun, Laura R. Hinds, Nicholas M. Varra, Daniel Tirado, Sarah J. Morton, Colleen A. McClung and Robert L. Spencer
eNeuro 6 December 2018, 5 (6) ENEURO.0455-18.2018; DOI: https://doi.org/10.1523/ENEURO.0455-18.2018
Elizabeth R. Woodruff
1Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO 80309
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Lauren E. Chun
1Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO 80309
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Laura R. Hinds
1Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO 80309
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Nicholas M. Varra
1Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO 80309
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Daniel Tirado
1Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO 80309
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Sarah J. Morton
1Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO 80309
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Colleen A. McClung
2Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA 15219
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Robert L. Spencer
1Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO 80309
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0455-18.2018
Published By 
Society for Neuroscience
History 
  • Received November 20, 2018
  • Accepted November 21, 2018
  • Published online December 6, 2018.
Copyright & Usage 
Copyright © 2018 Woodruff et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Elizabeth R. Woodruff1,
  2. Lauren E. Chun1,
  3. Laura R. Hinds1,
  4. Nicholas M. Varra1,
  5. Daniel Tirado1,
  6. Sarah J. Morton1,
  7. Colleen A. McClung2 and
  8. Robert L. Spencer1
  1. 1Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO 80309
  2. 2Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA 15219
  1. Correspondence should be addressed to Robert L. Spencer at the above address, E-mail: robert.spencer{at}colorado.edu.
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Author contributions

  1. Author contributions: E.R.W. and R.L.S. designed research; E.R.W., L.E.C., L.R.H., N.M.V., D.T., S.J.M., and R.L.S. performed research; C.A.M. contributed unpublished reagents/analytic tools; E.R.W., L.E.C., L.R.H., N.M.V., D.T., S.J.M., and R.L.S. analyzed data; E.R.W. and R.L.S. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the National Science Foundation Grant IOS1456706.

Funding

  • NSF | BIO | Division of Integrative Organismal Systems (IOS)

    IOS1456706

Other Version

  • You are viewing the most recent version of this article.
  • previous version (December 06, 2018).

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Coordination between Prefrontal Cortex Clock Gene Expression and Corticosterone Contributes to Enhanced Conditioned Fear Extinction Recall
Elizabeth R. Woodruff, Lauren E. Chun, Laura R. Hinds, Nicholas M. Varra, Daniel Tirado, Sarah J. Morton, Colleen A. McClung, Robert L. Spencer
eNeuro 6 December 2018, 5 (6) ENEURO.0455-18.2018; DOI: 10.1523/ENEURO.0455-18.2018

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Coordination between Prefrontal Cortex Clock Gene Expression and Corticosterone Contributes to Enhanced Conditioned Fear Extinction Recall
Elizabeth R. Woodruff, Lauren E. Chun, Laura R. Hinds, Nicholas M. Varra, Daniel Tirado, Sarah J. Morton, Colleen A. McClung, Robert L. Spencer
eNeuro 6 December 2018, 5 (6) ENEURO.0455-18.2018; DOI: 10.1523/ENEURO.0455-18.2018
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Keywords

  • circadian
  • clock gene
  • conditioned fear
  • corticosterone
  • prefrontal cortex
  • PTSD

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