Skip to main content

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Blog
    • Collections
    • Podcast
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • ABOUT
    • Overview
    • Editorial Board
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
  • SUBMIT

User menu

Search

  • Advanced search
eNeuro
eNeuro

Advanced Search

 

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Blog
    • Collections
    • Podcast
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • ABOUT
    • Overview
    • Editorial Board
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
  • SUBMIT
PreviousNext
Research ArticleNew Research, Disorders of the Nervous System

Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions

Paula M. Canas, Lisiane O. Porciúncula, Ana Patrícia Simões, Elisabete Augusto, Henrique B. Silva, Nuno J. Machado, Nélio Gonçalves, Tiago M. Alfaro, Francisco Q. Gonçalves, Inês M. Araújo, Joana I. Real, Joana E. Coelho, Geanne M. Andrade, Ramiro D. Almeida, Jiang-Fan Chen, Attila Köfalvi, Paula Agostinho and Rodrigo A. Cunha
eNeuro 17 December 2018, 5 (6) ENEURO.0385-18.2018; https://doi.org/10.1523/ENEURO.0385-18.2018
Paula M. Canas
1CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lisiane O. Porciúncula
1CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ana Patrícia Simões
1CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Ana Patrícia Simões
Elisabete Augusto
1CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Henrique B. Silva
1CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nuno J. Machado
1CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nélio Gonçalves
1CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Nélio Gonçalves
Tiago M. Alfaro
1CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Francisco Q. Gonçalves
1CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Francisco Q. Gonçalves
Inês M. Araújo
1CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Joana I. Real
1CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Joana I. Real
Joana E. Coelho
2Department of Neurology, Boston University School of Medicine, Boston, MA 02118
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Geanne M. Andrade
1CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ramiro D. Almeida
1CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Ramiro D. Almeida
Jiang-Fan Chen
2Department of Neurology, Boston University School of Medicine, Boston, MA 02118
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Attila Köfalvi
1CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Paula Agostinho
1CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal
3Faculty of Medicine, University of Coimbra, 3004-504 Coimbra, Portugal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rodrigo A. Cunha
1CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal
3Faculty of Medicine, University of Coimbra, 3004-504 Coimbra, Portugal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Rodrigo A. Cunha
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.1523/ENEURO.0385-18.2018
PubMed 
30627646
Published By 
Society for Neuroscience
History 
  • Received October 2, 2018
  • Accepted October 7, 2018
  • Published online December 17, 2018.
Copyright & Usage 
Copyright © 2018 Canas et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Paula M. Canas1,
  2. Lisiane O. Porciúncula1,
  3. Ana Patrícia Simões1,
  4. Elisabete Augusto1,
  5. Henrique B. Silva1,
  6. Nuno J. Machado1,
  7. Nélio Gonçalves1,
  8. Tiago M. Alfaro1,
  9. Francisco Q. Gonçalves1,
  10. Inês M. Araújo1,
  11. Joana I. Real1,
  12. Joana E. Coelho2,
  13. Geanne M. Andrade1,
  14. Ramiro D. Almeida1,
  15. Jiang-Fan Chen2,
  16. Attila Köfalvi1,
  17. Paula Agostinho1,3 and
  18. Rodrigo A. Cunha1,3
  1. 1CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal
  2. 2Department of Neurology, Boston University School of Medicine, Boston, MA 02118
  3. 3Faculty of Medicine, University of Coimbra, 3004-504 Coimbra, Portugal
  1. Correspondence should be addressed to Rodrigo A. Cunha, CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal, E-mail: cunharod{at}gmail.com.
View Full Text

Author contributions

  1. Author contributions: P.M.C., L.O.P., A.P.S., E.A., I.M.A., G.M.A., R.D.A., A.K., P.A., and R.A.C. designed research; P.M.C., L.O.P., A.P.S., E.A., H.B.S., N.J.M., N.G., T.M.A., F.Q.G., I.M.A., J.I.R., J.E.C., G.M.A., R.D.A., A.K., P.A., and R.A.C. performed research; J.-F.C. contributed unpublished reagents/analytic tools; P.M.C., L.O.P., A.P.S., E.A., H.B.S., N.J.M., N.G., T.M.A., F.Q.G., I.M.A., J.I.R., J.E.C., G.M.A., R.D.A., A.K., P.A., and R.A.C. analyzed data; R.A.C. wrote the paper.

Disclosures

  • R.A.C. is a scientific advisor of the Institute for Scientific Information (ISIC). All other authors declare no competing financial interests.

  • This work was supported by Santa Casa da Misericórdia, Faculty of Medicine of the University of Coimbra (FMUC)/Santander-Totta, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / Fundação para a Ciência e a Tecnologia (FCT), and European Regional Development Fund through Centro 2020 (CENTRO-01-0246-FEDER-000010 and CENTRO-01-0246-FEDER-000010) and through FCT (POCI-01-0145-FEDER-031274).

Funding

  • Santa Casa da Misericordia

  • Ministry of Education and Science | Fundação para a Ciência e a Tecnologia (FCT)

    POCI-01-0145-FEDER-031274
  • FMUC/Santander-Totta

  • CAPES-FCT

  • Centro 2020

    CENTRO-01-0246-FEDER-000010

Other Version

  • You are viewing the most recent version of this article.
  • previous version (December 17, 2018).

Online Impact

 

Article usage

Select a custom date range for the past year
E.g., 2025-07-20
to
E.g., 2025-07-20

Article usage: December 2018 to July 2025

AbstractFullPdf
Dec 20184586695
Total 20184586695
Jan 201959428076
Feb 20196212711
Mar 20193928422
Apr 20192425124
May 2019815016
Jun 2019920519
Jul 20191435630
Aug 20191279033
Oct 2019962616
Nov 2019492534
Dec 2019650313
Total 20197814497294
Jan 2020917624
Feb 2020125726
Mar 202032211
May 2020103643
Jun 202004415
Jul 202005333
Aug 202023513
Sep 202063636
Oct 202065717
Nov 202065325
Dec 202089130
Total 202062660273
Jan 202116222
Feb 202135512
Mar 202195315
Apr 202167424
May 202157021
Jun 202128125
Jul 202154524
Aug 202135516
Sep 202165518
Oct 202106224
Nov 202114829
Dec 202115617
Total 202142716247
Jan 202205417
Feb 202253623
Mar 202243630
Apr 202233315
May 202215419
Jun 202214415
Jul 202234713
Aug 202214517
Sep 202224221
Oct 202212920
Nov 202224117
Dec 202227515
Total 202225536222
Jan 202334213
Feb 20230477
Mar 20231478
Apr 202314410
May 202313810
Jun 20230388
Jul 202325621
Aug 202365032
Sep 20232938
Oct 202332319
Nov 202324709
Dec 202358221
Total 2023261238156
Jan 202467516
Feb 202477712
Mar 202445512
Apr 20241314425
May 202456013
Jun 2024136217
Jul 202485516
Aug 202444213
Sep 2024104132
Oct 202446224
Nov 202415111
Dec 20241539
Total 202476777200
Jan 2025105430
Feb 202566015
Mar 202536531
Apr 202535818
May 202535611
Jun 202596711
Jul 202583410
Total 202542394126
Total151288841613
Back to top

In this issue

eneuro: 5 (6)
eNeuro
Vol. 5, Issue 6
November/December 2018
  • Table of Contents
  • Index by author
Email

Thank you for sharing this eNeuro article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions
(Your Name) has forwarded a page to you from eNeuro
(Your Name) thought you would be interested in this article in eNeuro.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Citation Tools
Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions
Paula M. Canas, Lisiane O. Porciúncula, Ana Patrícia Simões, Elisabete Augusto, Henrique B. Silva, Nuno J. Machado, Nélio Gonçalves, Tiago M. Alfaro, Francisco Q. Gonçalves, Inês M. Araújo, Joana I. Real, Joana E. Coelho, Geanne M. Andrade, Ramiro D. Almeida, Jiang-Fan Chen, Attila Köfalvi, Paula Agostinho, Rodrigo A. Cunha
eNeuro 17 December 2018, 5 (6) ENEURO.0385-18.2018; DOI: 10.1523/ENEURO.0385-18.2018

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Share
Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions
Paula M. Canas, Lisiane O. Porciúncula, Ana Patrícia Simões, Elisabete Augusto, Henrique B. Silva, Nuno J. Machado, Nélio Gonçalves, Tiago M. Alfaro, Francisco Q. Gonçalves, Inês M. Araújo, Joana I. Real, Joana E. Coelho, Geanne M. Andrade, Ramiro D. Almeida, Jiang-Fan Chen, Attila Köfalvi, Paula Agostinho, Rodrigo A. Cunha
eNeuro 17 December 2018, 5 (6) ENEURO.0385-18.2018; DOI: 10.1523/ENEURO.0385-18.2018
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Significance Statement
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Acknowledgments
    • Footnotes
    • References
    • Synthesis
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • adenosine
  • convulsions
  • neuroprotection
  • synapse
  • synaptotoxicity
  • synatic plasticity

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

New Research

  • A Very Fast Time Scale of Human Motor Adaptation: Within Movement Adjustments of Internal Representations during Reaching
  • Optogenetic Activation of β-Endorphin Terminals in the Medial Preoptic Nucleus Regulates Female Sexual Receptivity
  • Hsc70 Ameliorates the Vesicle Recycling Defects Caused by Excess α-Synuclein at Synapses
Show more New Research

Disorders of the Nervous System

  • Release of Extracellular Matrix Components after Human Traumatic Brain Injury
  • Gene variants related to primary familial brain calcification: perspectives from bibliometrics and meta-analysis
Show more Disorders of the Nervous System

Subjects

  • Disorders of the Nervous System
  • Home
  • Alerts
  • Follow SFN on BlueSky
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Latest Articles
  • Issue Archive
  • Blog
  • Browse by Topic

Information

  • For Authors
  • For the Media

About

  • About the Journal
  • Editorial Board
  • Privacy Notice
  • Contact
  • Feedback
(eNeuro logo)
(SfN logo)

Copyright © 2025 by the Society for Neuroscience.
eNeuro eISSN: 2373-2822

The ideas and opinions expressed in eNeuro do not necessarily reflect those of SfN or the eNeuro Editorial Board. Publication of an advertisement or other product mention in eNeuro should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in eNeuro.