Research ArticleNew Research, Disorders of the Nervous System

Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions

Paula M. Canas, Lisiane O. Porciúncula, Ana Patrícia Simões, Elisabete Augusto, Henrique B. Silva, Nuno J. Machado, Nélio Gonçalves, Tiago M. Alfaro, Francisco Q. Gonçalves, Inês M. Araújo, Joana I. Real, Joana E. Coelho, Geanne M. Andrade, Ramiro D. Almeida, Jiang-Fan Chen, Attila Köfalvi, Paula Agostinho and Rodrigo A. Cunha
eNeuro 17 December 2018, 5 (6) ENEURO.0385-18.2018; https://doi.org/10.1523/ENEURO.0385-18.2018

Article Information

DOI 
https://doi.org/10.1523/ENEURO.0385-18.2018
PubMed 
30627646
Published By 
Society for Neuroscience
History 
  • Received October 2, 2018
  • Accepted October 7, 2018
  • Published online December 17, 2018.
Copyright & Usage 
Copyright © 2018 Canas et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Paula M. Canas1,
  2. Lisiane O. Porciúncula1,
  3. Ana Patrícia Simões1,
  4. Elisabete Augusto1,
  5. Henrique B. Silva1,
  6. Nuno J. Machado1,
  7. Nélio Gonçalves1,
  8. Tiago M. Alfaro1,
  9. Francisco Q. Gonçalves1,
  10. Inês M. Araújo1,
  11. Joana I. Real1,
  12. Joana E. Coelho2,
  13. Geanne M. Andrade1,
  14. Ramiro D. Almeida1,
  15. Jiang-Fan Chen2,
  16. Attila Köfalvi1,
  17. Paula Agostinho1,3 and
  18. Rodrigo A. Cunha1,3
  1. 1CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal
  2. 2Department of Neurology, Boston University School of Medicine, Boston, MA 02118
  3. 3Faculty of Medicine, University of Coimbra, 3004-504 Coimbra, Portugal
  1. Correspondence should be addressed to Rodrigo A. Cunha, CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal, E-mail: cunharod{at}gmail.com.
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Author contributions

  1. Author contributions: P.M.C., L.O.P., A.P.S., E.A., I.M.A., G.M.A., R.D.A., A.K., P.A., and R.A.C. designed research; P.M.C., L.O.P., A.P.S., E.A., H.B.S., N.J.M., N.G., T.M.A., F.Q.G., I.M.A., J.I.R., J.E.C., G.M.A., R.D.A., A.K., P.A., and R.A.C. performed research; J.-F.C. contributed unpublished reagents/analytic tools; P.M.C., L.O.P., A.P.S., E.A., H.B.S., N.J.M., N.G., T.M.A., F.Q.G., I.M.A., J.I.R., J.E.C., G.M.A., R.D.A., A.K., P.A., and R.A.C. analyzed data; R.A.C. wrote the paper.

Disclosures

  • R.A.C. is a scientific advisor of the Institute for Scientific Information (ISIC). All other authors declare no competing financial interests.

  • This work was supported by Santa Casa da Misericórdia, Faculty of Medicine of the University of Coimbra (FMUC)/Santander-Totta, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / Fundação para a Ciência e a Tecnologia (FCT), and European Regional Development Fund through Centro 2020 (CENTRO-01-0246-FEDER-000010 and CENTRO-01-0246-FEDER-000010) and through FCT (POCI-01-0145-FEDER-031274).

Funding

  • Santa Casa da Misericordia

  • Ministry of Education and Science | Fundação para a Ciência e a Tecnologia (FCT)

    POCI-01-0145-FEDER-031274

  • FMUC/Santander-Totta

  • CAPES-FCT

  • Centro 2020

    CENTRO-01-0246-FEDER-000010

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Online Impact

 

Article usage

Article usage: December 2018 to July 2025

AbstractFullPdf
Dec 20184586695
Total 20184586695
Jan 201959428076
Feb 20196212711
Mar 20193928422
Apr 20192425124
May 2019815016
Jun 2019920519
Jul 20191435630
Aug 20191279033
Oct 2019962616
Nov 2019492534
Dec 2019650313
Total 20197814497294
Jan 2020917624
Feb 2020125726
Mar 202032211
May 2020103643
Jun 202004415
Jul 202005333
Aug 202023513
Sep 202063636
Oct 202065717
Nov 202065325
Dec 202089130
Total 202062660273
Jan 202116222
Feb 202135512
Mar 202195315
Apr 202167424
May 202157021
Jun 202128125
Jul 202154524
Aug 202135516
Sep 202165518
Oct 202106224
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Dec 202115617
Total 202142716247
Jan 202205417
Feb 202253623
Mar 202243630
Apr 202233315
May 202215419
Jun 202214415
Jul 202234713
Aug 202214517
Sep 202224221
Oct 202212920
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Dec 202227515
Total 202225536222
Jan 202334213
Feb 20230477
Mar 20231478
Apr 202314410
May 202313810
Jun 20230388
Jul 202325621
Aug 202365032
Sep 20232938
Oct 202332319
Nov 202324709
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Total 2023261238156
Jan 202467516
Feb 202477712
Mar 202445512
Apr 20241314425
May 202456013
Jun 2024136217
Jul 202485516
Aug 202444213
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Total 202476777200
Jan 2025105430
Feb 202566015
Mar 202536531
Apr 202535818
May 202535611
Jun 202596711
Jul 202583410
Total 202542394126
Total151288841613
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eneuro: 5 (6)
eNeuro
Vol. 5, Issue 6
November/December 2018
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Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions
Paula M. Canas, Lisiane O. Porciúncula, Ana Patrícia Simões, Elisabete Augusto, Henrique B. Silva, Nuno J. Machado, Nélio Gonçalves, Tiago M. Alfaro, Francisco Q. Gonçalves, Inês M. Araújo, Joana I. Real, Joana E. Coelho, Geanne M. Andrade, Ramiro D. Almeida, Jiang-Fan Chen, Attila Köfalvi, Paula Agostinho, Rodrigo A. Cunha
eNeuro 17 December 2018, 5 (6) ENEURO.0385-18.2018; DOI: 10.1523/ENEURO.0385-18.2018
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