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Research ArticleNew Research, Disorders of the Nervous System

Enhancing GABAergic Transmission Improves Locomotion in a Caenorhabditis elegans Model of Spinal Muscular Atrophy

Chia-Yen Wu, David A. Gagnon, Juliette S. Sardin, Urva Barot, Alex Telenson, Paulo E. Arratia and Robert G. Kalb
eNeuro 16 November 2018, 5 (6) ENEURO.0289-18.2018; https://doi.org/10.1523/ENEURO.0289-18.2018
Chia-Yen Wu
1Department of Pediatrics, Division of Neurology, Research Institute, Children’s Hospital of Philadelphia, Philadelphia, PA 19104
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David A. Gagnon
2Department of Physics, Georgetown University, Washington, DC 20057
3Institute for Soft Matter Synthesis and Metrology, Georgetown University, Washington, DC 20057
4Department of Mechanical Engineering and Applied Mechanics, University of Pennsylvania, Philadelphia, PA 19104
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Juliette S. Sardin
4Department of Mechanical Engineering and Applied Mechanics, University of Pennsylvania, Philadelphia, PA 19104
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Urva Barot
1Department of Pediatrics, Division of Neurology, Research Institute, Children’s Hospital of Philadelphia, Philadelphia, PA 19104
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Alex Telenson
1Department of Pediatrics, Division of Neurology, Research Institute, Children’s Hospital of Philadelphia, Philadelphia, PA 19104
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Paulo E. Arratia
2Department of Physics, Georgetown University, Washington, DC 20057
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Robert G. Kalb
1Department of Pediatrics, Division of Neurology, Research Institute, Children’s Hospital of Philadelphia, Philadelphia, PA 19104
5Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104
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eneuro: 5 (6)
eNeuro
Vol. 5, Issue 6
November/December 2018
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Enhancing GABAergic Transmission Improves Locomotion in a Caenorhabditis elegans Model of Spinal Muscular Atrophy
Chia-Yen Wu, David A. Gagnon, Juliette S. Sardin, Urva Barot, Alex Telenson, Paulo E. Arratia, Robert G. Kalb
eNeuro 16 November 2018, 5 (6) ENEURO.0289-18.2018; DOI: 10.1523/ENEURO.0289-18.2018

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Enhancing GABAergic Transmission Improves Locomotion in a Caenorhabditis elegans Model of Spinal Muscular Atrophy
Chia-Yen Wu, David A. Gagnon, Juliette S. Sardin, Urva Barot, Alex Telenson, Paulo E. Arratia, Robert G. Kalb
eNeuro 16 November 2018, 5 (6) ENEURO.0289-18.2018; DOI: 10.1523/ENEURO.0289-18.2018
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Keywords

  • aging
  • FOXO transcription factor
  • neuromuscular junction
  • SMN protein
  • suppressor

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