Skip to main content

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Blog
    • Collections
    • Podcast
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • ABOUT
    • Overview
    • Editorial Board
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
  • SUBMIT

User menu

Search

  • Advanced search
eNeuro
eNeuro

Advanced Search

 

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Blog
    • Collections
    • Podcast
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • ABOUT
    • Overview
    • Editorial Board
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
  • SUBMIT
PreviousNext
Research ArticleNew Research, Disorders of the Nervous System

Enhancing GABAergic Transmission Improves Locomotion in a Caenorhabditis elegans Model of Spinal Muscular Atrophy

Chia-Yen Wu, David A. Gagnon, Juliette S. Sardin, Urva Barot, Alex Telenson, Paulo E. Arratia and Robert G. Kalb
eNeuro 16 November 2018, 5 (6) ENEURO.0289-18.2018; https://doi.org/10.1523/ENEURO.0289-18.2018
Chia-Yen Wu
1Department of Pediatrics, Division of Neurology, Research Institute, Children’s Hospital of Philadelphia, Philadelphia, PA 19104
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David A. Gagnon
2Department of Physics, Georgetown University, Washington, DC 20057
3Institute for Soft Matter Synthesis and Metrology, Georgetown University, Washington, DC 20057
4Department of Mechanical Engineering and Applied Mechanics, University of Pennsylvania, Philadelphia, PA 19104
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Juliette S. Sardin
4Department of Mechanical Engineering and Applied Mechanics, University of Pennsylvania, Philadelphia, PA 19104
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Urva Barot
1Department of Pediatrics, Division of Neurology, Research Institute, Children’s Hospital of Philadelphia, Philadelphia, PA 19104
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alex Telenson
1Department of Pediatrics, Division of Neurology, Research Institute, Children’s Hospital of Philadelphia, Philadelphia, PA 19104
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Paulo E. Arratia
2Department of Physics, Georgetown University, Washington, DC 20057
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Robert G. Kalb
1Department of Pediatrics, Division of Neurology, Research Institute, Children’s Hospital of Philadelphia, Philadelphia, PA 19104
5Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.1523/ENEURO.0289-18.2018
PubMed 
30627660
Published By 
Society for Neuroscience
History 
  • Received July 24, 2018
  • Revision received October 29, 2018
  • Accepted October 30, 2018
  • Published online November 16, 2018.
Copyright & Usage 
Copyright © 2018 Wu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Chia-Yen Wu1,
  2. David A. Gagnon2,3,4,
  3. Juliette S. Sardin4,
  4. Urva Barot1,
  5. Alex Telenson1,
  6. Paulo E. Arratia2 and
  7. Robert G. Kalb1,5
  1. 1Department of Pediatrics, Division of Neurology, Research Institute, Children’s Hospital of Philadelphia, Philadelphia, PA 19104
  2. 2Department of Physics, Georgetown University, Washington, DC 20057
  3. 3Institute for Soft Matter Synthesis and Metrology, Georgetown University, Washington, DC 20057
  4. 4Department of Mechanical Engineering and Applied Mechanics, University of Pennsylvania, Philadelphia, PA 19104
  5. 5Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104
  1. Correspondence should be addressed to Dr. Robert Kalb, Department of Neurology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Ward 13-275, Chicago, IL 60611, E-mail: robert.kalb1{at}northwestern.edu.
View Full Text

Author contributions

  1. Author contributions: C.-Y.W. and R.G.K. designed research; C.-Y.W., D.A.G., J.S.S., U.B., and A.T. performed research; P.E.A. contributed unpublished reagents/analytic tools; C.-Y.W., D.A.G., and J.S.S. analyzed data; C.-Y.W. and R.G.K. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by National Institutes of Health Grants T32 NS007413 (to C.-Y.W.), NS087077 and NS052325 (to R.G.K.), a National Science Foundation (NSF) Graduate Fellowship (D.A.G.), and NSF-CAREER-CBET-1437482 (to P.E.A.).

Funding

  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    T32 NS007413; NS087077; NS052325
  • NSF | ENG | Division of Chemical, Bioengineering, Environmental, and Transport Systems (CBET)

    NSF-CAREER-CBET-0954084

Other Version

  • You are viewing the most recent version of this article.
  • previous version (November 16, 2018).

Online Impact

 

Article usage

Select a custom date range for the past year
E.g., 2025-11-08
to
E.g., 2025-11-08

Article usage: November 2018 to November 2025

AbstractFullPdf
Nov 2018310051
Dec 2018148028
Total 2018458079
Jan 20199214437
Feb 2019218515
Mar 20192028640
Apr 20192617426
May 20191616021
Jun 20191310712
Jul 2019820921
Aug 20191731729
Oct 2019532419
Nov 201982187
Dec 201951416
Total 20192312165233
Jan 202086314
Feb 202095222
Mar 202033714
May 202075920
Jun 202035638
Jul 202084826
Aug 202043029
Sep 20205358
Oct 202075015
Nov 202077021
Dec 2020106912
Total 202071569219
Jan 202147112
Feb 202105012
Mar 202139623
Apr 2021210418
May 202157214
Jun 202126014
Jul 202105313
Aug 20213529
Sep 202104911
Oct 202136524
Nov 202196130
Dec 20211486
Total 202132781186
Jan 202215114
Feb 202243535
Mar 202234513
Apr 202254214
May 202256220
Jun 202224616
Jul 20221319
Aug 202213712
Sep 202203513
Oct 202206723
Nov 202274116
Dec 202245520
Total 202233547205
Jan 20231424
Feb 202354710
Mar 202313711
Apr 202304313
May 202343523
Jun 20230417
Jul 202344918
Aug 202333529
Sep 202325512
Oct 20232527
Nov 202315210
Dec 202326616
Total 202325554160
Jan 202455011
Feb 202495514
Mar 2024155921
Apr 202436312
May 2024310215
Jun 202438419
Jul 202448124
Aug 202445825
Sep 202435114
Oct 202456510
Nov 202466117
Dec 202465218
Total 202466781200
Jan 202566814
Feb 20258708
Mar 202556216
Apr 202515721
May 202545614
Jun 2025128919
Jul 2025147931
Aug 2025106616
Sep 20251533426
Oct 2025139325
Nov 20252181
Total 202590992191
Total100663891473
Back to top

In this issue

eneuro: 5 (6)
eNeuro
Vol. 5, Issue 6
November/December 2018
  • Table of Contents
  • Index by author
Email

Thank you for sharing this eNeuro article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Enhancing GABAergic Transmission Improves Locomotion in a Caenorhabditis elegans Model of Spinal Muscular Atrophy
(Your Name) has forwarded a page to you from eNeuro
(Your Name) thought you would be interested in this article in eNeuro.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Citation Tools
Enhancing GABAergic Transmission Improves Locomotion in a Caenorhabditis elegans Model of Spinal Muscular Atrophy
Chia-Yen Wu, David A. Gagnon, Juliette S. Sardin, Urva Barot, Alex Telenson, Paulo E. Arratia, Robert G. Kalb
eNeuro 16 November 2018, 5 (6) ENEURO.0289-18.2018; DOI: 10.1523/ENEURO.0289-18.2018

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Share
Enhancing GABAergic Transmission Improves Locomotion in a Caenorhabditis elegans Model of Spinal Muscular Atrophy
Chia-Yen Wu, David A. Gagnon, Juliette S. Sardin, Urva Barot, Alex Telenson, Paulo E. Arratia, Robert G. Kalb
eNeuro 16 November 2018, 5 (6) ENEURO.0289-18.2018; DOI: 10.1523/ENEURO.0289-18.2018
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Significance Statement
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Footnotes
    • References
    • Synthesis
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • aging
  • FOXO transcription factor
  • neuromuscular junction
  • SMN protein
  • suppressor

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

New Research

  • A Very Fast Time Scale of Human Motor Adaptation: Within Movement Adjustments of Internal Representations during Reaching
  • TrkB Signaling Influences Gene Expression in Cortistatin-Expressing Interneurons
  • Optogenetic Activation of β-Endorphin Terminals in the Medial Preoptic Nucleus Regulates Female Sexual Receptivity
Show more New Research

Disorders of the Nervous System

  • The PDGFBB-PDGFRβ Pathway and Laminins in Pericytes Are Involved in the Temporal Change of AQP4 Polarity during Temporal Lobe Epilepsy Pathogenesis
  • The Ventral Pallidum Innervates a Distinct Subset of Midbrain Dopamine Neurons
  • Rethinking Alzheimer's: Harnessing Cannabidiol to Modulate IDO and cGAS Pathways for Neuroinflammation Control
Show more Disorders of the Nervous System

Subjects

  • Disorders of the Nervous System
  • Home
  • Alerts
  • Follow SFN on BlueSky
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Latest Articles
  • Issue Archive
  • Blog
  • Browse by Topic

Information

  • For Authors
  • For the Media

About

  • About the Journal
  • Editorial Board
  • Privacy Notice
  • Contact
  • Feedback
(eNeuro logo)
(SfN logo)

Copyright © 2025 by the Society for Neuroscience.
eNeuro eISSN: 2373-2822

The ideas and opinions expressed in eNeuro do not necessarily reflect those of SfN or the eNeuro Editorial Board. Publication of an advertisement or other product mention in eNeuro should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in eNeuro.