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Research ArticleNew Research, Disorders of the Nervous System

Overweight Mice Show Coordinated Homeostatic and Hedonic Transcriptional Response across Brain

I. De Toma, I. E. Grabowicz, M. Fructuoso, D. Trujillano, B. Wilczyński and M. Dierssen
eNeuro 26 November 2018, 5 (6) ENEURO.0287-18.2018; DOI: https://doi.org/10.1523/ENEURO.0287-18.2018
I. De Toma
1Cellular and Systems Neurobiology, Systems Biology Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona 08003, Spain
2Universitat Pompeu Fabra (UPF), Barcelona 08002, Spain
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I. E. Grabowicz
3Institute of Informatics, Faculty of Mathematics, Informatics and Mechanics, University of Warsaw, 02-097 Warsaw, Poland
4Postgraduate School of Molecular Medicine, Medical University of Warsaw, 02-091 Warsaw, Poland
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M. Fructuoso
1Cellular and Systems Neurobiology, Systems Biology Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona 08003, Spain
2Universitat Pompeu Fabra (UPF), Barcelona 08002, Spain
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D. Trujillano
1Cellular and Systems Neurobiology, Systems Biology Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona 08003, Spain
2Universitat Pompeu Fabra (UPF), Barcelona 08002, Spain
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B. Wilczyński
3Institute of Informatics, Faculty of Mathematics, Informatics and Mechanics, University of Warsaw, 02-097 Warsaw, Poland
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M. Dierssen
1Cellular and Systems Neurobiology, Systems Biology Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona 08003, Spain
2Universitat Pompeu Fabra (UPF), Barcelona 08002, Spain
5Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), 46010 València, Spain
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0287-18.2018
Published By 
Society for Neuroscience
History 
  • Received July 24, 2018
  • Revision received October 9, 2018
  • Accepted October 15, 2018
  • Published online November 26, 2018.
Copyright & Usage 
Copyright © 2018 De Toma et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. I. De Toma1,2,
  2. I. E. Grabowicz3,4,
  3. M. Fructuoso1,2,
  4. D. Trujillano1,2,
  5. B. Wilczyński3 and
  6. M. Dierssen1,2,5
  1. 1Cellular and Systems Neurobiology, Systems Biology Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona 08003, Spain
  2. 2Universitat Pompeu Fabra (UPF), Barcelona 08002, Spain
  3. 3Institute of Informatics, Faculty of Mathematics, Informatics and Mechanics, University of Warsaw, 02-097 Warsaw, Poland
  4. 4Postgraduate School of Molecular Medicine, Medical University of Warsaw, 02-091 Warsaw, Poland
  5. 5Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), 46010 València, Spain
  1. Correspondence should be addressed to either of the following: Bartek Wil-czyński, Institute of Informatics, Faculty of Mathematics, Informatics and Mechanics, Banacha 2, Warszawa 02-097, Poland, E-mail: bartek{at}mimuw.edu.pl; or Mara Dierssen, Cellular and Systems Neurobiology, Systems Biology Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Carrer del Dr. Aiguader 88, Barcelona 08003, Spain, E-mail: mara.dierssen{at}crg.eu.
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Author contributions

  1. Author contributions: M.D., and B.W. designed research; M.D., D.T., and M.F. performed research; I.D.T., and I.E.G. analyzed data; I.D.T., I.E.G., and M.D. and B.W. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the Spanish Ministry, Industry of Economy and Competitiveness (MEIC) to the EMBL partnership; “Centro de Excelencia Severo Ochoa CERCA Programme / Generalitat de Catalunya”; the Centro de Investigación Biomédica en Red Enfermedades Raras (CIBER) of Rare Diseases; Departamento de Innovación, Universidadesy Empresa (DIUE) de la Generalitat de Catalunya [Grups consolidats SGR 2014/1125]; Spanish Ministry, Industry of Economy and Competitiveness (MEIC) [SAF2013-49129-C2-1-R and SAF2016-79956-R, Jerôme Lejeune Foundation]; Centro para el Desarrollo Tecnológico Industrial CDTI [“Smartfoods”]; This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement N°608959 (IMPULSE) and the Polish National Center for Research and Development grant [ERA-NET-NEURON/10/2013 to B.W. and I.E.G.]. New affiliation for IG: Institute of Computer Science Polish Academy of Sciences.

  • I.D.T. and I.E.G. are joint first authors.

  • I. E. Grabowicz’s present address: Institute of Computer Science Polish Academy of Sciences. ul. Jana Kazimierza 5, Warsaw, Poland.

Funding

  • Ministry of economy and Competitiveness (Spain)

    Severo Ochoa 2013-2017'; SAF2013-49129-C2-1-R and SAF2016-79956-R
  • Marie Curie IMPULSE

  • Centre for Industrial Technological Development (CDTI)

    Smartfoods
  • Era-net-Neuron

    PCIN-2013- 060
  • Polish National Center for Research and Development

    Era-net-Neuron/10/2013

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  • You are viewing the most recent version of this article.
  • previous version (November 26, 2018).

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Apr 20191711935
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Sep 202201613
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Overweight Mice Show Coordinated Homeostatic and Hedonic Transcriptional Response across Brain
I. De Toma, I. E. Grabowicz, M. Fructuoso, D. Trujillano, B. Wilczyński, M. Dierssen
eNeuro 26 November 2018, 5 (6) ENEURO.0287-18.2018; DOI: 10.1523/ENEURO.0287-18.2018

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Overweight Mice Show Coordinated Homeostatic and Hedonic Transcriptional Response across Brain
I. De Toma, I. E. Grabowicz, M. Fructuoso, D. Trujillano, B. Wilczyński, M. Dierssen
eNeuro 26 November 2018, 5 (6) ENEURO.0287-18.2018; DOI: 10.1523/ENEURO.0287-18.2018
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Keywords

  • chromatin
  • gene expression
  • hedonic and homeostatic responses
  • obesity
  • TADs

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