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a | SFM – OFQ [10 nm] – SFM | 1.49 ± 0.07 | 0.27 ± 0.03* p < 0.0001 d = 2.1557 | 0.40 ± 0.06 p = 0.0253 d = 0.2511 | | 102 | 3 |
b | SFM – OFQ [1 nm] – SFM | 1.69 ± 0.12 | 0.39 ± 0.04* p < 0.0001 d = 1.9704 | 0.87 ± 0.08* p < 0.0001 | | 69 | 3 |
c | SFM – OFQ [100 pm] – SFM (Fig. 2A) | 1.44 ± 0.07 | 0.32 ± 0.03* p < 0.0001 | 0.75 ± 0.07* p < 0.0001 | - | 144 | 5 |
d | SFM – OFQ [10 pm] – SFM | 1.53 ± 0.09 | 0.59 ± 0.08* p < 0.0001 | 1.15 ± 0.10* p < 0.0001 | - | 78 | 3 |
e | SFM – AAB – AAB + OFQ – SFM (Fig. 2B) | 2.14 ± 0.09 | 1.36 ± 0.09* p < 0.0001 | 0.48 ± 0.06* p < 0.0001 | 1.65 ± 0.09* p < 0.0001 | 113 | 3 |
f | SFM – UFP – UFP + OFQ – SFM (Fig. 3A) | 1.47 ± 0.08 | 1.42 ± 0.07 p = 0.4235 | 1.19 ± 0.07* p < 0.0001 | 1.14 ± 0.07 p = 0.6823 | 113 | 3 |
g | SFM – SB – SB + OFQ – SFM (Fig. 3B) | 1.86 ± 0.06 | 1.95 ± 0.05 p = 0.0532 | 1.42 ± 0.06* p < 0.0001 | 1.83 ± 0.06* p < 0.0001 | 244 | 6 |
h | PTX pretreated: SFM – OFQ – SFM (Fig. 4A) | 2.26 ± 0.11 | 1.91 ± 0.12* p < 0.0001 | 2.23 ± 0.12* p < 0.0001 | | 89 | 3 |
i | SFM – IBMX + FSK – IBMX + FSK + OFQ – SFM (Fig. 4B) | 1.68 ± 0.07 | 1.62 ± 0.07 p = 0.8887 | 0.46 ± 0.04* p < 0.0001 | 1.10 ± 0.07* p < 0.0001 | 161 | 3 |
j | 10 min Cs pretreated: Cs – Cs + OFQ (Fig. 4C) | 1.74 ± 0.06 | 1.15 ± 0.06* p < 0.0001 | | | 169 | 5 |
k | 20 min Ba pretreated: Ba – Ba + OFQ (Fig. 4D) | 1.71 ± 0.11 | 1.16 ± 0.11* p = 0.0035 | | | 36 | 4 |
l | SFM – TPNQ – TPNQ + OFQ – SFM (Fig. 5A) | 2.22 ± 0.11 | 2.32 ± 0.10 p = 0.416 | 0.64 ± 0.07* p < 0.0001 | 1.81 ± 0.13* p < 0.0001 | 80 | 3 |
m | SFM – naringin | 2.04 ± 0.15 | 2.00 ± 0.14 p = 0.6761 | | | 50 | 4 |
n | SFM – ML297 | 1.85 ± 0.08 | 1.83 ± 0.08 p = 0.6346 | | | 118 | 3 |
o | SFM – PMA – PMA + OFQ – SFM (Fig. 5C) | 1.40 ± 0.10 | 1.62 ± 0.08 p = 0.0122 | 1.37 ± 0.08 p = 0.0914 | 1.47 ± 0.09 p = 0.5211 | 118 | 4 |
p | SFM – BAC – SFM | 2.04 ± 0.10 | 0.30 ± 0.04* p < 0.0001 | 1.64 ± 0.10* p < 0.0001 | | 89 | 4 |
q | SFM – TPNQ – TPNQ + BAC – SFM (Fig. 5B) | 1.80 ± 0.14 | 2.02 ± 0.13 p = 0.0068 | 0.13 ± 0.04* p < 0.0001 | 1.71 ± 0.99* p < 0.0001 | 53 | 3 |
r | SFM – PMA – PMA + BAC – SFM (Fig. 5D) | 2.10 ± 0.12 | 2.19 ± 0.10 p = 0.8219 | 1.81 ± 0.12* p = 0.0167 | 2.08 ± 0.12 p = 0.1482 | 92 | 3 |