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Research ArticleNew Research, Sensory and Motor Systems

Targeted Activation of Cholinergic Interneurons Accounts for the Modulation of Dopamine by Striatal Nicotinic Receptors

Katherine R. Brimblecombe, Sarah Threlfell, Daniel Dautan, Polina Kosillo, Juan Mena-Segovia and Stephanie J. Cragg
eNeuro 12 October 2018, 5 (5) ENEURO.0397-17.2018; DOI: https://doi.org/10.1523/ENEURO.0397-17.2018
Katherine R. Brimblecombe
1Department of Physiology, Anatomy and Genetics, Sherrington Building, Oxford, UK
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Sarah Threlfell
1Department of Physiology, Anatomy and Genetics, Sherrington Building, Oxford, UK
2Oxford Parkinson’s Disease Centre, University of Oxford, Oxford OX1 3PT, UK
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Daniel Dautan
3MRC Anatomical Neuropharmacology Unit, Department of Pharmacology, Oxford, UK
4Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ
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Polina Kosillo
1Department of Physiology, Anatomy and Genetics, Sherrington Building, Oxford, UK
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Juan Mena-Segovia
3MRC Anatomical Neuropharmacology Unit, Department of Pharmacology, Oxford, UK
4Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ
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Stephanie J. Cragg
1Department of Physiology, Anatomy and Genetics, Sherrington Building, Oxford, UK
2Oxford Parkinson’s Disease Centre, University of Oxford, Oxford OX1 3PT, UK
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0397-17.2018
PubMed 
30406189
Published By 
Society for Neuroscience
History 
  • Received November 18, 2017
  • Revision received September 8, 2018
  • Accepted September 16, 2018
  • Published online October 12, 2018.
Copyright & Usage 
Copyright © 2018 Brimblecombe et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Katherine R. Brimblecombe1,
  2. Sarah Threlfell1,2,
  3. Daniel Dautan3,4,
  4. Polina Kosillo1,*,
  5. Juan Mena-Segovia3,4 and
  6. Stephanie J. Cragg1,2
  1. 1Department of Physiology, Anatomy and Genetics, Sherrington Building, Oxford, UK
  2. 2Oxford Parkinson’s Disease Centre, University of Oxford, Oxford OX1 3PT, UK
  3. 3MRC Anatomical Neuropharmacology Unit, Department of Pharmacology, Oxford, UK
  4. 4Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ
  1. Address correspondence to Stephanie J. Cragg, Department of Physiology, Anatomy and Genetics, University of Oxford, OX1 3PT, UK. E-mail: stephanie.cragg{at}dpag.ox.ac.uk.
  • ↵* P. Kosillo’s current address is Dept. of Molecular and Cell Biology, Berkeley, University of California, CA.

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Author contributions

  1. Author Contributions: All authors designed research; K.R.B., P.K., S.T., and D.D. performed research; and K.R.B., J.M.-S., and S.J.C. wrote the paper.

  • ↵* P. Kosillo’s current address is Dept. of Molecular and Cell Biology, Berkeley, University of California, CA.

Disclosures

  • The authors declare no competing financial interests.

  • Funded by MRC (grant MR/K013866/1) and Parkinson’s UK (J-1403; G-1305).

Funding

  • Medical Research Council (MRC)

    MR/K013866/1
  • Parkinson's UK

    J-1403; G-1305
  • Clarendon Fund

Other Version

  • You are viewing the most recent version of this article.
  • previous version (October 12, 2018).

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Oct 20185470172
Nov 201846017862
Dec 2018786125
Total 20181085239259
Jan 2019274617
Feb 2019179425
Mar 201988628
Apr 201976520
May 2019136120
Jun 2019114511
Jul 2019104613
Aug 201966326
Oct 201946222
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Dec 201946413
Total 2019114703218
Jan 202035513
Feb 202054825
Mar 202042412
May 202026131
Jun 202026233
Jul 202023011
Aug 20201246
Sep 202066028
Oct 202017724
Nov 202008727
Dec 2020711031
Total 202033638241
Jan 202138814
Feb 202136420
Mar 202157821
Apr 202137324
May 202137813
Jun 202106419
Jul 202116217
Aug 202126216
Sep 202106818
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Total 202123866233
Jan 202216315
Feb 202223611
Mar 20221569
Apr 202206316
May 202227924
Jun 20222629
Jul 20221539
Aug 202214617
Sep 202224516
Oct 202215925
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Dec 202245017
Total 202218646189
Jan 20230519
Feb 202304713
Mar 20230408
Total 2023013830
Total127332301170
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Targeted Activation of Cholinergic Interneurons Accounts for the Modulation of Dopamine by Striatal Nicotinic Receptors
Katherine R. Brimblecombe, Sarah Threlfell, Daniel Dautan, Polina Kosillo, Juan Mena-Segovia, Stephanie J. Cragg
eNeuro 12 October 2018, 5 (5) ENEURO.0397-17.2018; DOI: 10.1523/ENEURO.0397-17.2018

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Targeted Activation of Cholinergic Interneurons Accounts for the Modulation of Dopamine by Striatal Nicotinic Receptors
Katherine R. Brimblecombe, Sarah Threlfell, Daniel Dautan, Polina Kosillo, Juan Mena-Segovia, Stephanie J. Cragg
eNeuro 12 October 2018, 5 (5) ENEURO.0397-17.2018; DOI: 10.1523/ENEURO.0397-17.2018
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Keywords

  • acetylcholine
  • brainstem
  • cholinergic interneurons
  • dopamine
  • nicotinic receptors
  • striatum

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