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Research ArticleConfirmation, Cognition and Behavior

Blocking H2A.Z Incorporation via Tip60 Inhibition Promotes Systems Consolidation of Fear Memory in Mice

Klotilda Narkaj, Gilda Stefanelli, Malak Wahdan, Amber B. Azam, Firyal Ramzan, Carl Frank David Steininger Jr, Brandon J. Walters and Iva B. Zovkic
eNeuro 19 October 2018, 5 (5) ENEURO.0378-18.2018; https://doi.org/10.1523/ENEURO.0378-18.2018
Klotilda Narkaj
1Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
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Gilda Stefanelli
2Department of Psychology, University of Toronto Mississauga, Mississauga, Ontario L5L 1C6, Canada
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  • ORCID record for Gilda Stefanelli
Malak Wahdan
2Department of Psychology, University of Toronto Mississauga, Mississauga, Ontario L5L 1C6, Canada
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Amber B. Azam
1Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
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Firyal Ramzan
2Department of Psychology, University of Toronto Mississauga, Mississauga, Ontario L5L 1C6, Canada
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Carl Frank David Steininger Jr
2Department of Psychology, University of Toronto Mississauga, Mississauga, Ontario L5L 1C6, Canada
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Brandon J. Walters
3Department of Neurosciences & Mental Health, the Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
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Iva B. Zovkic
1Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
2Department of Psychology, University of Toronto Mississauga, Mississauga, Ontario L5L 1C6, Canada
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0378-18.2018
PubMed 
30417078
Published By 
Society for Neuroscience
History 
  • Received September 27, 2018
  • Accepted October 12, 2018
  • Published online October 19, 2018.
Copyright & Usage 
Copyright © 2018 Narkaj et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Klotilda Narkaj1,
  2. Gilda Stefanelli2,
  3. Malak Wahdan2,
  4. Amber B. Azam1,
  5. Firyal Ramzan2,
  6. Carl Frank David Steininger Jr2,
  7. Brandon J. Walters3 and
  8. Iva B. Zovkic1,2
  1. 1Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
  2. 2Department of Psychology, University of Toronto Mississauga, Mississauga, Ontario L5L 1C6, Canada
  3. 3Department of Neurosciences & Mental Health, the Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
  1. Correspondence should be addressed to Dr. Iva B. Zovkic, Assistant Professor, Department of Psychology, University of Toronto Mississauga, CCT Building, Room 4071, 3359 Mississauga Road, Mississauga, ON L5L 1C6, Canada. E-mail: iva.zovkic{at}utoronto.ca.
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Author contributions

  1. Author contributions: K.N., G.S., B.J.W., and I.B.Z. designed research; K.N., G.S., M.W., A.B.A., F.R., and C.F.D.S. performed research; K.N., B.J.W., and I.B.Z. analyzed data; K.N., B.J.W., and I.B.Z. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • Funding for this research was provided by a Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery Grant and a NSERC Discovery Accelerator Supplement, Canadian Institutes of Health Research Grant PJT-156414 (to I.B.Z.), and an Ontario Graduate Scholarship to (K.N.).

Funding

  • Ontario Graduate Scholarship

  • Gouvernement du Canada | Canadian Institutes of Health Research (CIHR)

    PJT 156414
  • Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (NSERC)

Other Version

  • You are viewing the most recent version of this article.
  • previous version (October 19, 2018).

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Oct 201817900120
Nov 201839014961
Dec 2018936440
Total 20182273213221
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Feb 2019165823
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May 20191212928
Jun 201997516
Jul 2019821032
Aug 20191427614
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Feb 202056320
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Jul 202004321
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Jul 202105018
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Total 20251431372
Total266054451502
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eneuro: 5 (5)
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September/October 2018
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Blocking H2A.Z Incorporation via Tip60 Inhibition Promotes Systems Consolidation of Fear Memory in Mice
Klotilda Narkaj, Gilda Stefanelli, Malak Wahdan, Amber B. Azam, Firyal Ramzan, Carl Frank David Steininger Jr, Brandon J. Walters, Iva B. Zovkic
eNeuro 19 October 2018, 5 (5) ENEURO.0378-18.2018; DOI: 10.1523/ENEURO.0378-18.2018

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Blocking H2A.Z Incorporation via Tip60 Inhibition Promotes Systems Consolidation of Fear Memory in Mice
Klotilda Narkaj, Gilda Stefanelli, Malak Wahdan, Amber B. Azam, Firyal Ramzan, Carl Frank David Steininger Jr, Brandon J. Walters, Iva B. Zovkic
eNeuro 19 October 2018, 5 (5) ENEURO.0378-18.2018; DOI: 10.1523/ENEURO.0378-18.2018
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Keywords

  • chromatin
  • epigenetics
  • histone variants
  • H2A.Z
  • Tip60
  • Histone Acetylation

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