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Research ArticleNew Research, Disorders of the Nervous System

p11 in Cholinergic Interneurons of the Nucleus Accumbens Is Essential for Dopamine Responses to Rewarding Stimuli

Y. Hanada, Y. Kawahara, Y. N. Ohnishi, T. Shuto, M. Kuroiwa, N. Sotogaku, P. Greengard, Y. Sagi and A. Nishi
eNeuro 16 October 2018, 5 (5) ENEURO.0332-18.2018; https://doi.org/10.1523/ENEURO.0332-18.2018
Y. Hanada
1Department of Pharmacology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan,
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Y. Kawahara
1Department of Pharmacology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan,
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Y. N. Ohnishi
1Department of Pharmacology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan,
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T. Shuto
1Department of Pharmacology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan,
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M. Kuroiwa
1Department of Pharmacology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan,
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N. Sotogaku
1Department of Pharmacology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan,
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P. Greengard
2Laboratory of Molecular and Cellular Neuroscience, the Rockefeller University, New York, NY 10065
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Y. Sagi
2Laboratory of Molecular and Cellular Neuroscience, the Rockefeller University, New York, NY 10065
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A. Nishi
1Department of Pharmacology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan,
2Laboratory of Molecular and Cellular Neuroscience, the Rockefeller University, New York, NY 10065
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0332-18.2018
PubMed 
30417079
Published By 
Society for Neuroscience
History 
  • Received August 27, 2018
  • Revision received October 4, 2018
  • Accepted October 9, 2018
  • Published online October 16, 2018.
Copyright & Usage 
Copyright © 2018 Hanada et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Y. Hanada1,
  2. Y. Kawahara1,
  3. Y. N. Ohnishi1,
  4. T. Shuto1,
  5. M. Kuroiwa1,
  6. N. Sotogaku1,
  7. P. Greengard2,
  8. Y. Sagi2 and
  9. A. Nishi1,2
  1. 1Department of Pharmacology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan,
  2. 2Laboratory of Molecular and Cellular Neuroscience, the Rockefeller University, New York, NY 10065
  1. Correspondence should be addressed to Dr. Akinori Nishi, Department of Pharmacology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka 830-0011, Japan, E-mail: nishia{at}med.kurume-u.ac.jp.
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Author contributions

  1. Author contributions: Y.K., P.G., Y.S., and A.N. designed research; Y.H., Y.K., Y.N.O., T.S., M.K., N.S., and Y.S. performed research; Y.H., Y.K., and A.N. analyzed data; Y.H., P.G., Y.S., and A.N. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research 16H05135 (to A.N.), United States Department of Defense-United States Army Medical Research and Materiel Command Grants W81XWH-16-1-0681 (to P.G.) and W81XWH-14-1-0130 and W81XWH-09-1-0401 (to Y.S.), the JPB Foundation Grant #475 (to P.G.), and the Black Family Foundation (P.G.). Authors thank Elisabeth Griggs for her assistance of visual abstract.

Funding

  • Japan Society for the Promotion of Science (JSPS)

    16H05135
  • US Department of Defense-USAMRMC

    W81XWH-16-1-0681; W81XWH-14-1-0130; W81XWH-09-1-0401
  • JPB Foundation

    #475
  • Black Family Foundation

Other Version

  • You are viewing the most recent version of this article.
  • previous version (October 16, 2018).
  • previous version (October 16, 2018).

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Oct 20183570103
Nov 2018217187103
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Total 2018674295236
Jan 2019427935
Feb 2019227014
Mar 20191311017
Apr 20191119949
May 20191611226
Jun 2019124616
Jul 2019127621
Aug 201986130
Oct 201977718
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Total 20191581004271
Jan 202066012
Feb 2020112823
Mar 202033812
May 202027743
Jun 202028481
Jul 202037658
Aug 202015623
Sep 202046119
Oct 2020511216
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Total 202048762328
Jan 202158817
Feb 20213595
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Apr 202127233
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Sep 202129017
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Total 202129947245
Jan 202227217
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May 202227511
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Jul 202215615
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Total 202223765152
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Apr 202518414
May 20251243
Total 202513393110
Total103557211740
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p11 in Cholinergic Interneurons of the Nucleus Accumbens Is Essential for Dopamine Responses to Rewarding Stimuli
Y. Hanada, Y. Kawahara, Y. N. Ohnishi, T. Shuto, M. Kuroiwa, N. Sotogaku, P. Greengard, Y. Sagi, A. Nishi
eNeuro 16 October 2018, 5 (5) ENEURO.0332-18.2018; DOI: 10.1523/ENEURO.0332-18.2018

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p11 in Cholinergic Interneurons of the Nucleus Accumbens Is Essential for Dopamine Responses to Rewarding Stimuli
Y. Hanada, Y. Kawahara, Y. N. Ohnishi, T. Shuto, M. Kuroiwa, N. Sotogaku, P. Greengard, Y. Sagi, A. Nishi
eNeuro 16 October 2018, 5 (5) ENEURO.0332-18.2018; DOI: 10.1523/ENEURO.0332-18.2018
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Keywords

  • Acetylcholine
  • anhedonia
  • cholinergic interneuron
  • dopamine
  • nucleus accumbens
  • p11

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