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Research ArticleNew Research, Neuronal Excitability

Distinctive Structural and Molecular Features of Myelinated Inhibitory Axons in Human Neocortex

Kristina D. Micheva, Edward F. Chang, Alissa L. Nana, William W. Seeley, Jonathan T. Ting, Charles Cobbs, Ed Lein, Stephen J Smith, Richard J. Weinberg and Daniel V. Madison
eNeuro 19 September 2018, 5 (5) ENEURO.0297-18.2018; https://doi.org/10.1523/ENEURO.0297-18.2018
Kristina D. Micheva
1Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA, 94305
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Edward F. Chang
2Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, 94143
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Alissa L. Nana
3Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, 94143
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William W. Seeley
3Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, 94143
4Department of Pathology, University of California San Francisco, San Francisco, CA, 94143
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Jonathan T. Ting
5Cell Types Program, Allen Institute for Brain Science, Seattle, WA, 98109
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Charles Cobbs
6The Ben and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, WA, 98122
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Ed Lein
5Cell Types Program, Allen Institute for Brain Science, Seattle, WA, 98109
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Stephen J Smith
5Cell Types Program, Allen Institute for Brain Science, Seattle, WA, 98109
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Richard J. Weinberg
7Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599
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Daniel V. Madison
1Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA, 94305
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0297-18.2018
PubMed 
30406183
Published By 
Society for Neuroscience
History 
  • Received July 30, 2018
  • Revision received September 2, 2018
  • Accepted September 10, 2018
  • Published online September 19, 2018.
Copyright & Usage 
Copyright © 2018 Micheva et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Kristina D. Micheva1,
  2. Edward F. Chang2,
  3. Alissa L. Nana3,
  4. William W. Seeley3,4,
  5. Jonathan T. Ting5,
  6. Charles Cobbs6,
  7. Ed Lein5,
  8. Stephen J Smith5,
  9. Richard J. Weinberg7 and
  10. Daniel V. Madison1
  1. 1Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA, 94305
  2. 2Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, 94143
  3. 3Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, 94143
  4. 4Department of Pathology, University of California San Francisco, San Francisco, CA, 94143
  5. 5Cell Types Program, Allen Institute for Brain Science, Seattle, WA, 98109
  6. 6The Ben and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, WA, 98122
  7. 7Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599
  1. Correspondence should be addressed to Kristina D. Micheva at the above address, E-mail: kmicheva{at}stanford.edu.
View Full Text

Author contributions

  1. Author contributions: K.D.M. and D.V.M. designed research; K.D.M. performed research; E.F.C., A.L.N., W.W.S., J.T.T., C.C., E.L., S.J.S., and R.J.W. contributed unpublished reagents/analytic tools; K.D.M. analyzed data; K.D.M. and R.J.W. wrote the paper.

Disclosures

  • K.D.M. and S.J.S. have founder’s equity interests in Aratome, LLC (Menlo Park, CA), an enterprise that produces array tomography materials and service. Also listed as inventors on two United States patents regarding array tomography methods that have been issued to Stanford University (United States patents 7,767,414 and 9,008,378). All other authors declare no competing financial interests.

  • This work was supported by National Institutes of Health Grants R01NS094499 (to D.V.M.), R01NS092474 (to S.J.S.), and R01NS039444 (to R.J.W.).

Funding

  • NIH

    R01NS094499; R01NS092474; R01NS092474

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AbstractFullPdf
Sep 2018206037
Oct 20183186596
Nov 201816722089
Dec 20187511057
Total 2018766395279
Jan 2019389921
Feb 2019199319
Mar 2019720410
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May 20191118830
Jun 20191019520
Jul 2019432924
Aug 2019661220
Oct 2019553823
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Total 20191173092211
Jan 202056015
Feb 202037727
Mar 202054416
May 202005419
Jun 202026215
Jul 202008517
Aug 202025114
Sep 202057730
Oct 2020159722
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Total 202046796215
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Jun 202106013
Jul 202119824
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Aug 202556517
Sep 2025814125
Oct 2025810422
Nov 20251312519
Dec 20251011536
Total 2025901094307
Jan 20261011534
Total 20261011534
Total115896941964
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Distinctive Structural and Molecular Features of Myelinated Inhibitory Axons in Human Neocortex
Kristina D. Micheva, Edward F. Chang, Alissa L. Nana, William W. Seeley, Jonathan T. Ting, Charles Cobbs, Ed Lein, Stephen J Smith, Richard J. Weinberg, Daniel V. Madison
eNeuro 19 September 2018, 5 (5) ENEURO.0297-18.2018; DOI: 10.1523/ENEURO.0297-18.2018

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Distinctive Structural and Molecular Features of Myelinated Inhibitory Axons in Human Neocortex
Kristina D. Micheva, Edward F. Chang, Alissa L. Nana, William W. Seeley, Jonathan T. Ting, Charles Cobbs, Ed Lein, Stephen J Smith, Richard J. Weinberg, Daniel V. Madison
eNeuro 19 September 2018, 5 (5) ENEURO.0297-18.2018; DOI: 10.1523/ENEURO.0297-18.2018
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Keywords

  • array tomography
  • GABA
  • myelin

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